scholarly journals Cingulate networks associated with gray matter loss in Parkinson’s disease show high expression of cholinergic genes in the healthy brain

2021 ◽  
Author(s):  
Arlin Keo ◽  
Oleh Dzyubachyk ◽  
Jeroen van der Grond ◽  
Anne Hafkemeijer ◽  
Wilma D.J. van de Berg ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
High Expression ◽  
Gray Matter Loss

scholarly journals Side of motor onset is associated with hemisphere-specific memory decline and lateralized gray matter loss in Parkinson's disease

2015 ◽  
Vol 21 (5) ◽  
pp. 465-470 ◽  
Author(s):  
Eun-Young Lee ◽  
Suman Sen ◽  
Paul J. Eslinger ◽  
Daymond Wagner ◽  
Lan Kong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Memory Decline ◽  
Specific Memory ◽  
Gray Matter Loss ◽  
Motor Onset

scholarly journals Cholinergic circuit genes in the healthy brain are differentially expressed in regions that exhibit gray matter loss in Parkinson’s disease

2019 ◽  
Author(s):  
Arlin Keo ◽  
Oleh Dzyubachyk ◽  
Jeroen van der Grond ◽  
Anne Hafkemeijer ◽  
Wilma D.J. van de Berg ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Regions ◽  
Protective Role ◽  
Anterior Cingulate ◽  
Ras Signaling ◽  
Clinical Events ◽  
Gray Matter Loss

AbstractStructural covariance networks are able to identify functionally organized brain regions by gray matter volume covariance. In Parkinson’s disease, the posterior cingulate network and anterior cingulate network showed decreased gray matter and therefore we examined the underlying molecular processes of these anatomical networks in the healthy brain. Whole brain transcriptomics from post-mortem samples from healthy adults, revealed upregulation of genes associated with serotonin, GPCR, GABA, glutamate, and RAS signaling pathways in these PD-related regions. Our results also suggest involvement of the cholinergic circuit, in which genes NPPA, SOSTDC1, and TYRP1 may play a protective role. Furthermore, both networks were associated with memory and neuropsychiatric disorders that overlap with Parkinson’s disease symptoms. The identified genes and pathways contribute to healthy functions of the posterior and anterior cingulate networks and disruptions to these functions may in turn contribute to the pathological and clinical events observed in Parkinson’s disease.

Minor hallucinations reflect early gray matter loss and predict subjective cognitive decline in Parkinson's disease

2020 ◽  
Author(s):  
H. Bejr‐kasem ◽  
F. Sampedro ◽  
J. Marín‐Lahoz ◽  
S. Martínez‐Horta ◽  
J. Pagonabarraga ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Subjective Cognitive Decline ◽  
Gray Matter Loss

Corticolimbic gray matter loss in Parkinson’s disease without dementia

2010 ◽  
Vol 17 (8) ◽  
pp. 1090-1097 ◽  
Author(s):  
Y. Nishio ◽  
K. Hirayama ◽  
A. Takeda ◽  
Y. Hosokai ◽  
T. Ishioka ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Gray Matter Loss

Correlations between gray matter reductions and cognitive deficits in dementia with Lewy Bodies and Parkinson's disease with dementia

2009 ◽  
Vol 24 (12) ◽  
pp. 1740-1746 ◽  
Author(s):  
Cristina Sanchez-Castaneda ◽  
Ramon Rene ◽  
Blanca Ramirez-Ruiz ◽  
Jaume Campdelacreu ◽  
Jordi Gascon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Cognitive Deficits ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Parkinson’S Disease With Dementia

scholarly journals The increased gray matter volumes of precentral gyri in Parkinson's disease patients with diphasic dyskinesia

Aging ◽  
2019 ◽  
Vol 11 (21) ◽  
pp. 9661-9671
Author(s):  
Yan Zhi ◽  
Min Wang ◽  
Yong-Sheng Yuan ◽  
Yu-Ting Shen ◽  
Ke-Wei Ma ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Gray Matter Volumes

Gray matter atrophy and freezing of gait in Parkinson's disease: Is the evidence black-on-white?

2013 ◽  
Vol 29 (1) ◽  
pp. 134-139 ◽  
Author(s):  
Talia Herman ◽  
Keren Rosenberg-Katz ◽  
Yael Jacob ◽  
Nir Giladi ◽  
Jeffrey M. Hausdorff
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Freezing Of Gait ◽  
Gray Matter Atrophy

Differentiating Patients with Parkinson’s Disease from Normal Controls Using Gray Matter in the Cerebellum

2016 ◽  
Vol 16 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Ling-Li Zeng ◽  
Liang Xie ◽  
Hui Shen ◽  
Zhiguo Luo ◽  
Peng Fang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Normal Controls

scholarly journals Morphometric changes of gray matter in Parkinson's disease with depression: A voxel-based morphometry study

2008 ◽  
Vol 23 (1) ◽  
pp. 42-46 ◽  
Author(s):  
Adam Feldmann ◽  
Zsolt Illes ◽  
Peter Kosztolanyi ◽  
Eniko Illes ◽  
Andrea Mike ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Voxel Based Morphometry
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