Role of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) in Neurodegenerative Dementias

2021 ◽  
Author(s):  
Sadat Shafi ◽  
Archu Singh ◽  
Abdallah Mohammad Ibrahim ◽  
Noora Alhajri ◽  
Tareq Abu Izneid ◽  
...  
Keyword(s):  
Myeloid Cells ◽  
Neurodegenerative Dementias

scholarly journals Myeloid HIF1α Is Involved in the Extent of Orthodontically Induced Tooth Movement

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 796
Author(s):  
Christian Kirschneck ◽  
Nadine Straßmair ◽  
Fabian Cieplik ◽  
Eva Paddenberg ◽  
Jonathan Jantsch ◽  
...  
Keyword(s):  
Bone Density ◽  
Periodontal Ligament ◽  
Tooth Movement ◽  
Hypoxia Inducible Factor ◽  
Myeloid Cells ◽  
Orthodontic Tooth Movement ◽  
Periodontal Ligament Fibroblasts ◽  
Expression Of Genes ◽  
Periodontal Bone Loss

During orthodontic tooth movement, transcription factor hypoxia-inducible factor 1α (HIF1α) is stabilised in the periodontal ligament. While HIF1α in periodontal ligament fibroblasts can be stabilised by mechanical compression, in macrophages pressure application alone is not sufficient to stabilise HIF1α. The present study was conducted to investigate the role of myeloid HIF1α during orthodontic tooth movement. Orthodontic tooth movement was performed in wildtype and Hif1αΔmyel mice lacking HIF1α expression in myeloid cells. Subsequently, µCT images were obtained to determine periodontal bone loss, extent of orthodontic tooth movement and bone density. RNA was isolated from the periodontal ligament of the control side and the orthodontically treated side, and the expression of genes involved in bone remodelling was investigated. The extent of tooth movement was increased in Hif1αΔmyel mice. This may be due to the lower bone density of the Hif1αΔmyel mice. Deletion of myeloid Hif1α was associated with increased expression of Ctsk and Acp5, while both Rankl and its decoy receptor Opg were increased. HIF1α from myeloid cells thus appears to play a regulatory role in orthodontic tooth movement.

scholarly journals Non-autophagy role of Atg5 and NBR1 in unconventional secretion of IL-12 prevents gut dysbiosis and inflammation

2020 ◽  
Author(s):  
Seth D. Merkley ◽  
Samuel M. Goodfellow ◽  
Yan Guo ◽  
Zoe E.R. Wilton ◽  
Janie R. Byrum ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Intestinal Inflammation ◽  
Critical Role ◽  
Myeloid Cells ◽  
Late Endosome ◽  
Gut Dysbiosis ◽  
Cargo Receptor ◽  
Unconventional Secretion ◽  
Genetic Deletion

ABSTRACTIntestinal myeloid cells play a critical role in balancing intestinal homeostasis and inflammation. Here, we report that expression of the autophagy related 5 (Atg5) protein in myeloid cells prevents dysbiosis and excessive intestinal inflammation by limiting IL-12 production. Mice with a selective genetic deletion of Atg5 in myeloid cells (Atg5ΔMye) showed signs of dysbiosis prior to colitis and exhibited severe intestinal inflammation upon colitis induction that was characterized by increased IFNγ production. This increase in IFNγ was due to excess IL-12 secretion from Atg5-deficient myeloid cells. Atg5 functions to limit IL-12 secretion through modulation of late endosome (LE) acidity. Additionally, the autophagy cargo receptor NBR1, which accumulates in Atg5-deficient cells, played a role by delivering IL-12 to LE. Restoration of the intestinal microbiota and alleviation of intestinal inflammation was achieved by genetic deletion of IL-12 in Atg5ΔMye mice. In summary, Atg5 expression in intestinal myeloid cells acts as an anti-inflammatory brake to regulate IL-12 thus preventing dysbiosis and uncontrolled IFNγ-driven intestinal inflammation.

scholarly journals Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases

2022 ◽  
Author(s):  
Augusto Bleve ◽  
Francesca Motta ◽  
Barbara Durante ◽  
Chiara Pandolfo ◽  
Carlo Selmi ◽  
...  
Keyword(s):  
Myeloid Cells ◽  
Age Related

scholarly journals The Role of Neonatal Gr-1+ Myeloid Cells in a Murine Model of Rhesus-Rotavirus–Induced Biliary Atresia

2018 ◽  
Vol 188 (11) ◽  
pp. 2617-2628
Author(s):  
Ruizhong Zhang ◽  
Zefeng Lin ◽  
Ming Fu ◽  
Xisi Guan ◽  
Jiakang Yu ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Murine Model ◽  
Myeloid Cells

scholarly journals Protective role of ErbB3 signaling in myeloid cells during adaptation to cardiac pressure overload

2021 ◽  
Vol 152 ◽  
pp. 1-16
Author(s):  
Haifeng Yin ◽  
Amanda J. Favreau-Lessard ◽  
Joanne T. deKay ◽  
Yodit R. Herrmann ◽  
Michael P. Robich ◽  
...  
Keyword(s):  
Myeloid Cells ◽  
Pressure Overload ◽  
Protective Role ◽  
Erbb3 Signaling

Got your mother in a whirl: The role of maternal T cells and myeloid cells in pregnancy

HLA ◽  
2020 ◽  
Vol 96 (5) ◽  
pp. 561-579 ◽  
Author(s):  
Michael Eikmans ◽  
Anita van der Zwan ◽  
Frans H. J. Claas ◽  
Marie‐Louise van der Hoorn ◽  
Sebastiaan Heidt
Keyword(s):  
T Cells ◽  
Myeloid Cells ◽  
In Pregnancy
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