Association between lifetime depression history, hippocampal volume and memory in non‐amnestic mild cognitive impairment

2021 ◽  
Author(s):  
Isabella Hoi Kei Leung ◽  
Kathryn Mary Broadhouse ◽  
Loren Mowszowski ◽  
Haley M LaMonica ◽  
Jake Robert Palmer ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Depression History

The reduced left hippocampal volume related to the delayed P300 latency in amnestic mild cognitive impairment

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Lijuan Gao ◽  
Lihua Gu ◽  
Hao Shu ◽  
Jiu Chen ◽  
Jianli Zhu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Parahippocampal Gyrus ◽  
Structural Basis ◽  
P300 Latency ◽  
Information Processing Speed ◽  
Amci Group ◽  
The Relationship

Abstract Background Amnestic mild cognitive impairment (aMCI) is characterized by delayed P300 latency and reduced grey matter (GM) volume, respectively. The relationship between the features in aMCI is unclear. This study was to investigate the relationship between the altered P300 latency and the GM volume in aMCI. Methods Thirty-four aMCI and 34 well-matched normal controls (NC) were studied using electroencephalogram during a visual oddball task and scanned with MRI. Both tests were finished in the same day. Results As compared with the NC group, the aMCI group exhibited delayed P300 latency in parietal cortex and reduced GM volumes in bilateral temporal pole and left hippocampus/parahippocampal gyrus. A remarkable negative correlation was found between delayed P300 latency and reduced left hippocampal volume only in the aMCI group. Interestingly, the mediating analysis found P300 latency significantly mediated the association between right supramarginal gyrus volume and information processing speed indicated by Stroop Color and Word Test A scores. Conclusions The association between delayed P300 latency and reduced left hippocampal volume in aMCI subjects suggests that reduced left hippocampal volume may be the potential structural basis of delayed P300 latency.

The Effects of Three Months of Aerobic Dance on Hippocampal Volume and Cognition in Elderly People with Amnestic Mild Cognitive Impairment: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Yi Zhu ◽  
Yaxin Gao ◽  
Ming Qi ◽  
Ming Xiao ◽  
Han Wu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly People ◽  
Controlled Trial ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Control Group ◽  
Aerobic Dance ◽  
Randomized Controlled

Abstract Whether dancing could increases the hippocampal volume of seniors with amnestic mild cognitive impairment(aMCI) remains debatable. The aim of the present study was to investigate the influence of aerobic dance on hippocampal volume and cognition after three months' aerobic dance in older adults with aMCI. In this randomized controlled trial, 68 elderly people with aMCI were randomized to either aerobic dance group or the control group using 1:1 allocation ratio. Specially designed aerobic dance routine was performed by the dance group three times a week for three months, while all participants received monthly health care education after inclusion. MRI with a 3.0 T MRI scanner and cognitive assessments were performed before and after intervention. The high-resolution 3D T1-weighted anatomical images were acquired for the analysis of hippocampal volume. A total of 35 participants (mean age: 71.51 ± 6.62 years) were randomized into aerobic dance group and 33(mean age:69.82 ± 7.74 years ) into control group, and all the data was analyzed based on the intention to treat (ITT) method. Patients in the treatment group showed increased volume in the right hippocampus (mean difference [MD] in right hippocampus volume over 3 months 0.13; 95% confidence interval [CI] 0.05, 0.21; p<0.001) and memory enhancement (MD in Memory Scale-Revised Logical Memory change over 3 months 2.12; 95% CI -0.06, 4.13; p = 0.02) compared to the control group. In conclusion, three months of aerobic dance could increase the volume of right hippocampus and improve episodic memory in elderly persons with aMCI. This study was registered on the Chinese Clinical Trial Registry (www.chictr.org.cn). Registration number：ChiCTR-INR-15007420.

Hippocampal Volume and the Mini-Mental State Examination in the Diagnosis of Amnestic Mild Cognitive Impairment

2007 ◽  
Vol 188 (5) ◽  
pp. 1404-1410 ◽  
Author(s):  
Melissa J. Slavin ◽  
Claire K. Sandstrom ◽  
Thanh-Thu T. Tran ◽  
P. Murali Doraiswamy ◽  
Jeffrey R. Petrella
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
State Examination

[P1-346]: EFFECTS OF AEROBIC EXERCISE ON PROGRESSION OF HIPPOCAMPAL VOLUME AND COGNITION IN AMNESTIC MILD COGNITIVE IMPAIRMENT DUE TO AD

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P389-P389 ◽  
Author(s):  
Camila Vieira de Ligo Teixeira ◽  
Thiago Junqueira Ribeiro Rezende ◽  
Thamires NC. Magalhães ◽  
Marina Weiler ◽  
Ana Flavia MKC Cassani ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Aerobic Exercise ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment

scholarly journals Altered Volume and Structural Connectivity of the Hippocampus in Alzheimer’s Disease and Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 13 ◽  
Author(s):  
Feng Feng ◽  
Weijie Huang ◽  
Qingqing Meng ◽  
Weijun Hao ◽  
Hongxiang Yao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diffusion Tensor ◽  
Structural Connectivity ◽  
Hippocampal Volume ◽  
Brain Regions ◽  
Amnestic Mild Cognitive Impairment ◽  
Hippocampal Atrophy

Background: Hippocampal atrophy is a characteristic of Alzheimer’s disease (AD). However, alterations in structural connectivity (number of connecting fibers) between the hippocampus and whole brain regions due to hippocampal atrophy remain largely unknown in AD and its prodromal stage, amnestic mild cognitive impairment (aMCI).Methods: We collected high-resolution structural MRI (sMRI) and diffusion tensor imaging (DTI) data from 36 AD patients, 30 aMCI patients, and 41 normal control (NC) subjects. First, the volume and structural connectivity of the bilateral hippocampi were compared among the three groups. Second, correlations between volume and structural connectivity in the ipsilateral hippocampus were further analyzed. Finally, classification ability by hippocampal volume, its structural connectivity, and their combination were evaluated.Results: Although the volume and structural connectivity of the bilateral hippocampi were decreased in patients with AD and aMCI, only hippocampal volume correlated with neuropsychological test scores. However, positive correlations between hippocampal volume and ipsilateral structural connectivity were displayed in patients with AD and aMCI. Furthermore, classification accuracy (ACC) was higher in AD vs. aMCI and aMCI vs. NC by the combination of hippocampal volume and structural connectivity than by a single parameter. The highest values of the area under the receiver operating characteristic (ROC) curve (AUC) in every two groups were all obtained by combining hippocampal volume and structural connectivity.Conclusions: Our results showed that the combination of hippocampal volume and structural connectivity (number of connecting fibers) is a new perspective for the discrimination of AD and aMCI.

scholarly journals 541 - MRI-BASED MEASUREMENT OF HIPPOCAMPAL VOLUME IN PATIENTS WITH DEMENTIA

2021 ◽  
Vol 33 (S1) ◽  
pp. 83-84
Author(s):  
Supriya Satapathy ◽  
D. Phani Bhushan ◽  
T. Nageshwar Rao ◽  
M. Satyanarayana
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Activities Of Daily Living ◽  
Vascular Dementia ◽  
Daily Living ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Population Increase

Background:Dementia due to probable Alzheimer’s disease (AD) represents between 60 and 80% of all dementias. The total number of estimated AD cases worldwide by 2030 is 65.7 million and 115.4 million by 2050; this represents a twofold population increase in the next 20 years.Magnetic resonance imaging (MRI) has been the primary tool of interest to link hippocampal volume loss with dementia firmly.MRI-based volumetry has been proposed as a promising biomarker.Hippocampal volumetry is useful in discriminating not only cognitively normal individuals from those with dementia but can also differentiate Mild Cognitive Impairment (MCI) from various types of dementia.Research objective:To measure hippocampal volume in various types of dementia. (MMSE) and Activities of daily living (ADL) in patients with dementia.Method:A cross-sectional study conducted for period of one year among 21 patients with Alzheimer’s, vascular dementia, amnestic mild cognitive impairment and 20 healthy age matched controls. MMSE scale was used to stratify patients on cognitive function impairments. ADL scale to assess functional status of the patient ability to perform activities of daily living independently in diverse settings. Hippocampal volume measured using MRI 1.5 T Philips Ingenia, a coronal T1-weighted FFE (Fast Field Echo) 3D sequence.Results:Total Hippocampal volume was reduced by 35% in Alzheimer’s disease, 27% in vascular dementia and 10% in amnestic mild cognitive impairment, compared with control groupConclusions:Moderate positive correlation between mean total hippocampal volume and MMSE scores in patients with dementia which was statistically significant. (P value= 0.001).

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