scholarly journals C‐low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress

2020 ◽  
Author(s):  
Susannah C. Walker ◽  
Antonia Cavieres ◽  
Valentín Peñaloza‐Sancho ◽  
Wael El‐Deredy ◽  
Francis P. McGlone ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Dynamic Touch ◽  
Mild Stress ◽  
Stress Resilience ◽  
Low Threshold

Author response for "C‐Low Threshold Mechanoafferent Targeted Dynamic Touch Modulates Stress Resilience in Rats Exposed to Chronic Mild Stress"

2020 ◽  
Author(s):  
Susannah C. Walker ◽  
Antonia Cavieres ◽  
Valentín Peñaloza‐Sancho ◽  
Wael El‐Deredy ◽  
Francis P. McGlone ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Author Response ◽  
Dynamic Touch ◽  
Mild Stress ◽  
Stress Resilience ◽  
Low Threshold

Metabolomic identification of molecular changes associated with stress resilience in the chronic mild stress rat model of depression

Metabolomics ◽  
2012 ◽  
Vol 9 (2) ◽  
pp. 433-443 ◽  
Author(s):  
Wei-Hua Shao ◽  
Song-Hua Fan ◽  
Yang Lei ◽  
Guo-En Yao ◽  
Jian-Jun Chen ◽  
...  
Keyword(s):  
Rat Model ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Resilience ◽  
Molecular Changes

scholarly journals Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 972
Author(s):  
Barbara Planchez ◽  
Natalia Lagunas ◽  
Anne-Marie Le Guisquet ◽  
Marc Legrand ◽  
Alexandre Surget ◽  
...  
Keyword(s):  
Mouse Model ◽  
Water Maze ◽  
Chronic Mild Stress ◽  
Tail Suspension Test ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Maze Procedure ◽  
Mild Stress ◽  
Protective Effects ◽  
Stress Resilience

Many studies evaluated the functional role of adult hippocampal neurogenesis (AHN) and its key role in cognitive functions and mood regulation. The effects of promoting AHN on the recovery of stress-induced symptoms have been well studied, but its involvement in stress resilience remains elusive. We used a mouse model enabling us to foster AHN before the exposure to unpredictable chronic mild stress (UCMS) to evaluate the potential protective effects of AHN on stress, assessing the depressive-like phenotype and executive functions. For this purpose, an inducible transgenic mouse model was used to delete the pro-apoptotic gene Bax from neural progenitors four weeks before UCMS, whereby increasing the survival of adult-generated neurons. Our results showed that UCMS elicited a depressive-like phenotype, highlighted by a deteriorated coat state, a higher immobility duration in the tail suspension test (TST), and a delayed reversal learning in a water maze procedure. Promoting AHN before UCMS was sufficient to prevent the development of stressed-induced behavioral changes in the TST and the water maze, reflecting an effect of AHN on stress resilience. Taken together, our data suggest that increasing AHN promotes stress resilience on some depressive-like symptoms but also in cognitive symptoms, which are often observed in MD.

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