scholarly journals How to study anxiety and depression in rodent models of chronic pain?

2020 ◽  
Author(s):  
Mélanie Kremer ◽  
Léa J. Becker ◽  
Michel Barrot ◽  
Ipek Yalcin
Keyword(s):  
Chronic Pain ◽  
Anxiety And Depression ◽  
Rodent Models

scholarly journals Brain-Derived Neurotrophic Factor and Immune Cells in Osteoarthritis, Chronic Low Back Pain, and Chronic Widespread Pain Patients: Association with Anxiety and Depression

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 327
Author(s):  
Dominique Josephine Dimmek ◽  
Christoph Korallus ◽  
Sabine Buyny ◽  
Gutenbrunner Christoph ◽  
Ralf Lichtinghagen ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Immune Cells ◽  
Chronic Widespread Pain ◽  
Anxiety And Depression ◽  
Low Back ◽  
Widespread Pain ◽  
Chronic Pain Patients ◽  
Pain Patients

Background and Objectives: Musculoskeletal dysfunction can induce several types of chronic pain syndromes. It is of particular interest to elucidate the pathomechanism of different forms of chronic pain. It is possible that patients who have developed chronic widespread pain (CWP) may endure different pathomechanisms as compared to those who suffer from local pain (osteoarthritis, OA) and regional pain (chronic low back pain, cLBP), especially with regard to pain regulation and its related biomediators. The aim of this study was to determine the differences in pathomechanisms among these patients by measuring pain-related biomediators, particularly brain-derived neurotrophic factor (BDNF). Additionally, subpopulations of immune cells were determined in parallel. Materials and Methods: Patients and healthy subjects (HSs) were recruited (age and gender-matched). BDNF was measured from serum samples of patients and HSs and the data of body composition parameters were recorded. Additionally, both patients and HSs were asked to fill in questionnaires related to pain intensity, anxiety, and depression. Results: Our results highlight that the levels of both free and total BDNF are significantly lower in pain patients compared to HSs, with p values of 0.041 and 0.024, respectively. The number of CD3− CD56bright natural killer (NK) cells shows significant differences between the groups. Comparing all chronic pain patients with HSs reveals a significantly lower number of CD4+ CD8+ T cells (p = 0.031), CD3− CD56bright NK cells (p = 0.049) and CD20+ CD3− cells (p = 0.007). Conclusions: To conclude, it seems that a general conformity between the pathomechanisms of different chronic pain diseases exists, although there are unique findings only in specific chronic pain patients.

scholarly journals The Importance of Positive Events When Living With Chronic Pain

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 309-309
Author(s):  
Julie Kircher ◽  
Susan Charles ◽  
Nancy Sin ◽  
David Almeida
Keyword(s):  
Chronic Pain ◽  
Negative Affect ◽  
Positive Affect ◽  
Positive Emotions ◽  
Later Life ◽  
Anxiety And Depression ◽  
Positive Events ◽  
Pain Status ◽  
Daily Events ◽  
Multi Level

Abstract Chronic pain is a common condition in later life that is related to high levels of anxiety and depression. One reason why chronic pain is related to affective distress is that this condition may prevent people from deriving the same positive emotions from enjoyable activities. Few studies, however, have examined how exposure and reactivity to daily events differ by chronic pain status. We hypothesized that those with chronic pain will have less exposure and less positive affect reactivity to positive daily events compared to those without chronic pain. Participants from the diary substudy of MIDUS (N = 1,733; nChronicPain = 658, nNoPain = 1,075; M = 56 years-old) completed eight interview days. Chronic pain status was unrelated to the frequency of positive events. Multi-level models revealed that although people with chronic pain had lower levels of daily positive affect, they reacted more positively to daily events (γ = -.033, SE = .010, p < .0001). As a result, levels of daily positive affect on days when people experienced a positive event did not vary by pain status (MChronicPain = 2.73, MNoPain = 2.75). People with chronic pain averaged higher levels of daily negative affect compared to people without chronic pain (MChronicPain = .21, M NoPain =.20), but, on days when they experience a positive event, those with chronic pain had a greater decrease in their negative affect. Findings suggest that positive events impact those with chronic pain more than they do individuals without chronic pain.

scholarly journals Sleep patterns and symptoms of anxiety and depression in patients with chronic pain

2009 ◽  
Vol 67 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Martha M.C. Castro ◽  
Carla Daltro
Keyword(s):  
Chronic Pain ◽  
Sleep Disturbances ◽  
Myofascial Pain ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Sleep Patterns ◽  
Symptoms Of Depression ◽  
High Prevalence ◽  
The Mean

BACKGROUND: Sleep disturbances and symptoms of anxiety and depression have been shown to be involved in the genesis and perpetuation of chronic pain. OBJECTIVE: To evaluate sleep patterns and the prevalence of symptoms of anxiety and depression in patients with chronic pain. METHOD: Four hundred consecutive patients referred to a chronic pain outpatient clinic were investigated using patient charts, the numerical Visual Analogue Scale for the evaluation of pain, the Hospital Anxiety and Depression scale and the Mini-Sleep Questionnaire. RESULTS: The mean age of patients was 45.6±11.4 years. The most frequent medical diagnosis was myofascial pain followed by neuropathic pain. The prevalence of symptoms of anxiety was 72.8%, depression 93% and altered sleep patterns 93%. CONCLUSION: This study revealed a high prevalence of symptoms of depression and anxiety and alterations in sleep patterns in patients with chronic pain, justifying investigation into these disturbances in this group of patients.

scholarly journals Ethosuximide improves chronic pain-induced anxiety- and depression-like behaviors

2019 ◽  
Vol 29 (12) ◽  
pp. 1419-1432
Author(s):  
Nicolas Kerckhove ◽  
Ludivine Boudieu ◽  
Guillaume Ourties ◽  
Justine Bourdier ◽  
Laurence Daulhac ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Anxiety And Depression

scholarly journals Feasibility of a Hybrid Web-Based and In-Person Self-management Intervention Aimed at Preventing Acute to Chronic Pain Transition After Major Lower Extremity Trauma (iPACT-E-Trauma): A Pilot Randomized Controlled Trial

Pain Medicine ◽  
2019 ◽  
Vol 20 (10) ◽  
pp. 2018-2032 ◽  
Author(s):  
M Bérubé ◽  
C Gélinas ◽  
N Feeley ◽  
G Martorella ◽  
J Côté ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Catastrophizing ◽  
Controlled Trial ◽  
Self Management ◽  
Anxiety And Depression ◽  
Management Intervention ◽  
Randomized Controlled ◽  
Extremity Trauma ◽  
Experimental Group ◽  
Pilot Randomized Controlled Trial

Abstract Objective 1) To assess the feasibility of research methods to test a self-management intervention aimed at preventing acute to chronic pain transition in patients with major lower extremity trauma (iPACT-E-Trauma) and 2) to evaluate its potential effects at three and six months postinjury. Design A pilot randomized controlled trial (RCT) with two parallel groups. Setting A supraregional level 1 trauma center. Methods Fifty-six adult patients were randomized. Participants received the intervention or an educational pamphlet. Several parameters were evaluated to determine the feasibility of the research methods. The potential efficacy of iPACT-E-Trauma was evaluated with measures of pain intensity and pain interference with activities. Results More than 80% of eligible patients agreed to participate, and an attrition rate of ≤18% was found. Less than 40% of screened patients were eligible, and obtaining baseline data took 48 hours postadmission on average. Mean scores of mild pain intensity and pain interference with daily activities (<4/10) on average were obtained in both groups at three and six months postinjury. Between 20% and 30% of participants reported moderate to high mean scores (≥4/10) on these outcomes at the two follow-up time measures. The experimental group perceived greater considerable improvement in pain (60% in the experimental group vs 46% in the control group) at three months postinjury. Low mean scores of pain catastrophizing (Pain Catastrophizing Scale score < 30) and anxiety and depression (Hospital Anxiety and Depression Scale scores ≤ 10) were obtained through the end of the study. Conclusions Some challenges that need to be addressed in a future RCT include the small proportion of screened patients who were eligible and the selection of appropriate tools to measure the development of chronic pain. Studies will need to be conducted with patients presenting more serious injuries and psychological vulnerability or using a stepped screening approach.

scholarly journals Novel agonist of α4β2* neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain

2018 ◽  
Vol Volume 11 ◽  
pp. 2453-2462 ◽  
Author(s):  
Roberto T Sudo ◽  
Kenichiro Hayashida ◽  
Aluízio N Santos ◽  
Masahito Kawatani ◽  
Carlos ES Monteiro ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nicotinic Receptor ◽  
Rodent Models ◽  
Neuronal Nicotinic Receptor

scholarly journals Efficacy of a transdiagnostic emotion–focused exposure treatment for chronic pain patients with comorbid anxiety and depression

Pain ◽  
2019 ◽  
Vol 160 (8) ◽  
pp. 1708-1718 ◽  
Author(s):  
Katja Boersma ◽  
Martin Södermark ◽  
Hugo Hesser ◽  
Ida K. Flink ◽  
Björn Gerdle ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Anxiety And Depression ◽  
Exposure Treatment ◽  
Comorbid Anxiety ◽  
Chronic Pain Patients ◽  
Pain Patients
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