Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula

2018 ◽  
Vol 49 (5) ◽  
pp. 687-700 ◽  
Author(s):  
Yosuke Saga ◽  
Christian C. Ruff ◽  
Léon Tremblay
Keyword(s):  
Basal Ganglia ◽  
Anterior Insula ◽  
Avoidance Behaviors ◽  
Approach Avoidance ◽  
Stimulation Of

scholarly journals Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Veronica Ghiglieri ◽  
Vincenza Bagetta ◽  
Valentina Pendolino ◽  
Barbara Picconi ◽  
Paolo Calabresi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Experimental Models ◽  
Striatal Neurons ◽  
Da Receptors ◽  
Electrophysiological Studies ◽  
Plastic Changes ◽  
Stimulation Of

In Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the postsynaptic striatal neurons that might account for the appearance of L-DOPA-induced dyskinesia (LID). Experimental models of LID have been widely used and extensively characterized in rodents and electrophysiological studies provided remarkable insights into the inner mechanisms underlying L-DOPA-induced corticostriatal plastic changes. Here we provide an overview of recent findings that represent a further step into the comprehension of mechanisms underlying maladaptive changes of basal ganglia functions in response to L-DOPA and associated to development of LID.

Blunt impact as deterrent: human approach-avoidance behaviors and other stress responses studied within a paintball gaming context

2006 ◽  
Author(s):  
Kenneth R. Short ◽  
Michael T. Bergen ◽  
Robert M. DeMarco ◽  
Florence B. Chua ◽  
Richard J. Servatius
Keyword(s):  
Stress Responses ◽  
Blunt Impact ◽  
Avoidance Behaviors ◽  
Approach Avoidance

The Effects of Destructive Lesions and Stimulation of the Basal Ganglia on Speech Mechanisms

1966 ◽  
Vol 27 (1-3) ◽  
pp. 197-207 ◽  
Author(s):  
K. Hermann ◽  
J.W. Turner ◽  
F.J. Gillingham ◽  
R.M. Gaze
Keyword(s):  
Basal Ganglia ◽  
Stimulation Of

Effect of electrical stimulation of the cerebral cortex on the expression of the fos protein in the basal ganglia

Neuroscience ◽  
1997 ◽  
Vol 81 (1) ◽  
pp. 93-112 ◽  
Author(s):  
V Sgambato ◽  
V Abo ◽  
M Rogard ◽  
M.J Besson ◽  
J.M Deniau
Keyword(s):  
Cerebral Cortex ◽  
Electrical Stimulation ◽  
Basal Ganglia ◽  
Fos Protein ◽  
Stimulation Of

scholarly journals Stimulation in the Rat Anterior Insula and Anterior Cingulate During an Effortful Weightlifting Task

2021 ◽  
Vol 15 ◽  
Author(s):  
Carlos Silva ◽  
Blake S. Porter ◽  
Kristin L. Hillman
Keyword(s):  
High Frequency ◽  
Low Frequency ◽  
Insular Cortex ◽  
Cingulate Cortex ◽  
Anterior Insula ◽  
Anterior Cingulate ◽  
High Frequency Stimulation ◽  
Sprague Dawley ◽  
Frequency Stimulation ◽  
Stimulation Of

When performing tasks, animals must continually assess how much effort is being expended, and gage this against ever-changing physiological states. As effort costs mount, persisting in the task may be unwise. The anterior cingulate cortex (ACC) and the anterior insular cortex are implicated in this process of cost-benefit decision-making, yet their precise contributions toward driving effortful persistence are not well understood. Here we investigated whether electrical stimulation of the ACC or insular cortex would alter effortful persistence in a novel weightlifting task (WLT). In the WLT an animal is challenged to pull a rope 30 cm to trigger food reward dispensing. To make the action increasingly effortful, 45 g of weight is progressively added to the rope after every 10 successful pulls. The animal can quit the task at any point – with the rope weight at the time of quitting taken as the “break weight.” Ten male Sprague-Dawley rats were implanted with stimulating electrodes in either the ACC [cingulate cortex area 1 (Cg1) in rodent] or anterior insula and then assessed in the WLT during stimulation. Low-frequency (10 Hz), high-frequency (130 Hz), and sham stimulations were performed. We predicted that low-frequency stimulation (LFS) of Cg1 in particular would increase persistence in the WLT. Contrary to our predictions, LFS of Cg1 resulted in shorter session duration, lower break weights, and fewer attempts on the break weight. High-frequency stimulation of Cg1 led to an increase in time spent off-task. LFS of the anterior insula was associated with a marginal increase in attempts on the break weight. Taken together our data suggest that stimulation of the rodent Cg1 during an effortful task alters certain aspects of effortful behavior, while insula stimulation has little effect.

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