Midfrontal theta transcranial alternating current stimulation modulates behavioural adjustment after error execution

2018 ◽  
Vol 48 (10) ◽  
pp. 3159-3170 ◽  
Author(s):  
Gabriele Fusco ◽  
Michele Scandola ◽  
Matteo Feurra ◽  
Enea F. Pavone ◽  
Simone Rossi ◽  
...  
Keyword(s):  
Alternating Current ◽  
Transcranial Alternating Current Stimulation ◽  
Behavioural Adjustment ◽  
After Error

scholarly journals A specific phase of transcranial alternating current stimulation at the β frequency boosts repetitive paired-pulse TMS-induced plasticity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hisato Nakazono ◽  
Katsuya Ogata ◽  
Akinori Takeda ◽  
Emi Yamada ◽  
Shinichiro Oka ◽  
...  
Keyword(s):  
Cortical Excitability ◽  
Motor Evoked Potentials ◽  
Single Pulse ◽  
Alternating Current ◽  
Dependent Manner ◽  
Synaptic Efficacy ◽  
Paired Pulse ◽  
Transcranial Alternating Current Stimulation ◽  
In Trans ◽  
Specific Phase

AbstractTranscranial alternating current stimulation (tACS) at 20 Hz (β) has been shown to modulate motor evoked potentials (MEPs) when paired with transcranial magnetic stimulation (TMS) in a phase-dependent manner. Repetitive paired-pulse TMS (rPPS) with I-wave periodicity (1.5 ms) induced short-lived facilitation of MEPs. We hypothesized that tACS would modulate the facilitatory effects of rPPS in a frequency- and phase-dependent manner. To test our hypothesis, we investigated the effects of combined tACS and rPPS. We applied rPPS in combination with peak or trough phase tACS at 10 Hz (α) or β, or sham tACS (rPPS alone). The facilitatory effects of rPPS in the sham condition were temporary and variable among participants. In the β tACS peak condition, significant increases in single-pulse MEPs persisted for over 30 min after the stimulation, and this effect was stable across participants. In contrast, β tACS in the trough condition did not modulate MEPs. Further, α tACS parameters did not affect single-pulse MEPs after the intervention. These results suggest that a rPPS-induced increase in trans-synaptic efficacy could be strengthened depending on the β tACS phase, and that this technique could produce long-lasting plasticity with respect to cortical excitability.

scholarly journals Online and offline effects of transcranial alternating current stimulation of the primary motor cortex

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ivan Pozdniakov ◽  
Alicia Nunez Vorobiova ◽  
Giulia Galli ◽  
Simone Rossi ◽  
Matteo Feurra
Keyword(s):  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Cortical Excitability ◽  
Motor Evoked Potentials ◽  
Random Noise ◽  
Single Pulse ◽  
Alternating Current ◽  
Online Application ◽  
Transcranial Random Noise Stimulation ◽  
Transcranial Alternating Current Stimulation

AbstractTranscranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that allows interaction with endogenous cortical oscillatory rhythms by means of external sinusoidal potentials. The physiological mechanisms underlying tACS effects are still under debate. Whereas online (e.g., ongoing) tACS over the motor cortex induces robust state-, phase- and frequency-dependent effects on cortical excitability, the offline effects (i.e. after-effects) of tACS are less clear. Here, we explored online and offline effects of tACS in two single-blind, sham-controlled experiments. In both experiments we used neuronavigated transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) as a probe to index changes of cortical excitability and delivered M1 tACS at 10 Hz (alpha), 20 Hz (beta) and sham (30 s of low-frequency transcranial random noise stimulation; tRNS). Corticospinal excitability was measured by single pulse TMS-induced motor evoked potentials (MEPs). tACS was delivered online in Experiment 1 and offline in Experiment 2. In Experiment 1, the increase of MEPs size was maximal with the 20 Hz stimulation, however in Experiment 2 neither the 10 Hz nor the 20 Hz stimulation induced tACS offline effects. These findings support the idea that tACS affects cortical excitability only during online application, at least when delivered on the scalp overlying M1, thereby contributing to the development of effective protocols that can be applied to clinical populations.

scholarly journals Conducting double-blind placebo-controlled clinical trials of transcranial alternating current stimulation (tACS)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Flavio Frohlich ◽  
Justin Riddle
Keyword(s):  
Rational Design ◽  
Target Identification ◽  
Alternating Current ◽  
Sine Wave ◽  
Brain Network ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Cortical Oscillations ◽  
Transcranial Alternating Current Stimulation ◽  
Therapeutic Platform

AbstractMany psychiatric and neurological illnesses can be conceptualized as oscillopathies defined as pathological changes in brain network oscillations. We previously proposed the application of rational design for the development of non-invasive brain stimulation for the modulation and restoration of cortical oscillations as a network therapeutic. Here, we show how transcranial alternating current stimulation (tACS), which applies a weak sine-wave electric current to the scalp, may serve as a therapeutic platform for the treatment of CNS illnesses. Recently, an initial series of double-blind, placebo-controlled treatment trials of tACS have been published. Here, we first map out the conceptual underpinnings of such trials with focus on target identification, engagement, and validation. Then, we discuss practical aspects that need to be considered for successful trial execution, with particular regards to ensuring successful study blind. Finally, we briefly review the few published double-blind tACS trials and conclude with a proposed roadmap to move the field forward with the goal of moving from pilot trials to convincing efficacy studies of tACS.

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