Remodeling of the number and structure of dendritic spines in the medial amygdala: From prepubertal sexual dimorphism to puberty and effect of sexual experience in male rats

2018 ◽  
Vol 48 (2) ◽  
pp. 1851-1865 ◽  
Author(s):  
Mariana Zancan ◽  
Rick Shandler R. Cunha ◽  
Francielle Schroeder ◽  
Léder L. Xavier ◽  
Alberto A. Rasia‐Filho
Keyword(s):  
Sexual Dimorphism ◽  
Dendritic Spines ◽  
Sexual Experience ◽  
Male Rats ◽  
Medial Amygdala

Establishment of partner preference in male rats: Effect of prenatal letrozole and sexual experience

2019 ◽  
Vol 109 ◽  
pp. 56-63 ◽  
Author(s):  
Sandra Olvera-Hernández ◽  
Alejandra Hernández ◽  
Rebeca Reyes ◽  
Alonso Fernández-Guasti
Keyword(s):  
Sexual Experience ◽  
Male Rats ◽  
Partner Preference

scholarly journals The human medial amygdala: structure, diversity, and complexity of dendritic spines

2015 ◽  
Vol 227 (4) ◽  
pp. 440-459 ◽  
Author(s):  
Aline Dall'Oglio ◽  
Ana Carolina L. Dutra ◽  
Jorge E. Moreira ◽  
Alberto A. Rasia-Filho
Keyword(s):  
Dendritic Spines ◽  
Medial Amygdala ◽  
Structure Diversity

scholarly journals Ultrastructural features of neurons and synaptic contacts in the posterodorsal medial amygdala of adult male rats

2006 ◽  
Vol 208 (5) ◽  
pp. 565-575 ◽  
Author(s):  
E. E. S. Hermel ◽  
M. C. Faccioni-Heuser ◽  
S. Marcuzzo ◽  
A. A. Rasia-Filho ◽  
M. Achaval
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Medial Amygdala ◽  
Synaptic Contacts

scholarly journals Descriptive findings on the morphology of dendritic spines in the rat medial amygdala

2010 ◽  
Vol 483 (2) ◽  
pp. 152-156 ◽  
Author(s):  
Janaína Brusco ◽  
Aline Dall’Oglio ◽  
Lenaldo B. Rocha ◽  
Marcos A. Rossi ◽  
Jorge E. Moreira ◽  
...  
Keyword(s):  
Dendritic Spines ◽  
Medial Amygdala

scholarly journals Environmental levels of oestrogenic and antiandrogenic compounds feminize digit ratios in male rats and their unexposed male progeny

2013 ◽  
Vol 280 (1768) ◽  
pp. 20131532 ◽  
Author(s):  
Jacques Auger ◽  
Dominique Le Denmat ◽  
Raymond Berges ◽  
Ludivine Doridot ◽  
Benjamin Salmon ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Endocrine Disruptors ◽  
Digit Ratio ◽  
Male Rats ◽  
X Rays ◽  
Ratio Measurement ◽  
Male Progeny ◽  
Digit Ratios ◽  
Gestational Exposure ◽  
Prenatal Androgen

Digit length ratios, especially the second-to-fourth digit ratio (2D : 4D), are associated with various pathological and behavioural conditions in many species including humans and are dependent upon prenatal androgen to oestrogen balance. It is unknown whether digit ratios are modified by environmental exposure to ubiquitous endocrine disruptors . We studied the effect on adult male Wistar rat digit ratios of a gestational exposure to the oestrogenic and antiandrogenic compounds bisphenol A (BPA), genistein and vinclozolin, in low doses, and in combination with investigating in parallel a possible sexual dimorphism of this trait. We also investigated the effects on the male progeny not exposed during gestation. X-rays were taken of the left and right forepaws, and 2D–5D proximal to distal phalanx distances were measured by a standardized procedure based on semi-automatic image analysis. We provide evidence that there is a sexual dimorphism of digit ratios in the Wistar rat, and we found that BPA alone or in combination with genistein and vinclozolin significantly feminized digit ratios in male rats. Intriguingly, significant feminization of digit ratios was also found in the unexposed male progeny of males that had been exposed to compound mixtures. In conclusion, prenatal environmental levels of endocrine-active substances permanently disrupt digit ratios. Digit ratio measurement in adults is thus a promising biomarker of prenatal exposure to low-dose endocrine disruptors in rodents, with potential implications for future studies in humans.

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