Effects of forced, passive, and voluntary exercise on spinal motoneurons changes after peripheral nerve injury

2017 ◽  
Vol 46 (12) ◽  
pp. 2885-2892 ◽  
Author(s):  
Ariadna Arbat‐Plana ◽  
Xavier Navarro ◽  
Esther Udina
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Voluntary Exercise ◽  
Spinal Motoneurons

scholarly journals Redistribution of Kv2.1 ion channels on spinal motoneurons following peripheral nerve injury

2014 ◽  
Vol 1547 ◽  
pp. 1-15 ◽  
Author(s):  
Shannon H. Romer ◽  
Kathleen M. Dominguez ◽  
Marc W. Gelpi ◽  
Adam S. Deardorff ◽  
Robert C. Tracy ◽  
...  
Keyword(s):  
Ion Channels ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Spinal Motoneurons

SynCAM1 expression correlates with restoration of central synapses on spinal motoneurons after two different models of peripheral nerve injury

2009 ◽  
Vol 517 (5) ◽  
pp. 670-682 ◽  
Author(s):  
Johan Zelano ◽  
Alexander Berg ◽  
Sebastian Thams ◽  
Nils P. Hailer ◽  
Staffan Cullheim
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Spinal Motoneurons ◽  
Central Synapses

scholarly journals Neuronal BDNF Signaling Is Necessary for the Effects of Treadmill Exercise on Synaptic Stripping of Axotomized Motoneurons

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Joey Krakowiak ◽  
Caiyue Liu ◽  
Chandana Papudesu ◽  
P. Jillian Ward ◽  
Jennifer C. Wilhelm ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Knockout Mice ◽  
Peripheral Nerve Injury ◽  
Treadmill Exercise ◽  
Glutamate Transporter ◽  
Acid Decarboxylase ◽  
Spinal Motoneurons ◽  
Synaptic Inputs ◽  
Glutamate Transporter 1

The withdrawal of synaptic inputs from the somata and proximal dendrites of spinal motoneurons following peripheral nerve injury could contribute to poor functional recovery. Decreased availability of neurotrophins to afferent terminals on axotomized motoneurons has been implicated as one cause of the withdrawal. No reduction in contacts made by synaptic inputs immunoreactive to the vesicular glutamate transporter 1 and glutamic acid decarboxylase 67 is noted on axotomized motoneurons if modest treadmill exercise, which stimulates the production of neurotrophins by spinal motoneurons, is applied after nerve injury. In conditional, neuron-specific brain-derived neurotrophic factor (BDNF) knockout mice, a reduction in synaptic contacts onto motoneurons was noted in intact animals which was similar in magnitude to that observed after nerve transection in wild-type controls. No further reduction in coverage was found if nerves were cut in knockout mice. Two weeks of moderate daily treadmill exercise following nerve injury in these BDNF knockout mice did not affect synaptic inputs onto motoneurons. Treadmill exercise has a profound effect on synaptic inputs to motoneurons after peripheral nerve injury which requires BDNF production by those postsynaptic cells.

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