Neuropeptide S precursor knockout mice display memory and arousal deficits

2017 ◽  
Vol 46 (1) ◽  
pp. 1689-1700 ◽  
Author(s):  
Xiaobin Liu ◽  
Wei Si ◽  
Celia Garau ◽  
Kay Jüngling ◽  
Hans-Christian Pape ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Neuropeptide S ◽  
Display Memory

scholarly journals Neuropeptide S-Mediated Modulation of Prepulse Inhibition Depends on Age, Gender, Stimulus-Timing, and Attention

2021 ◽  
Vol 14 (5) ◽  
pp. 489
Author(s):  
Wei Si ◽  
Xiaobin Liu ◽  
Hans-Christian Pape ◽  
Rainer K. Reinscheid
Keyword(s):  
Prepulse Inhibition ◽  
Knockout Mice ◽  
Young Male ◽  
Careful Examination ◽  
Neuropeptide S ◽  
Compensatory Mechanisms ◽  
Attentional Processes ◽  
Attentional Deficits ◽  
Knockout Animals

Conflicting reports about the role of neuropeptide S (NPS) in animal models of psychotic-like behavior and inconsistent results from human genetic studies seeking potential associations with schizophrenia prompted us to reevaluate the effects of NPS in the prepulse inhibition (PPI) paradigm in mice. Careful examination of NPS receptor (NPSR1) knockout mice at different ages revealed that PPI deficits are only expressed in young male knockout animals (<12 weeks of age), that can be replicated in NPS precursor knockout mice and appear strain-independent, but are absent in female mice. PPI deficits can be aggravated by MK-801 and alleviated by clozapine. Importantly, treatment of wildtype mice with a centrally-active NPSR1 antagonist was able to mimic PPI deficits. PPI impairment in young male NPSR1 and NPS knockout mice may be caused by attentional deficits that are enhanced by increasing interstimulus intervals. Our data reveal a substantial NPS-dependent developmental influence on PPI performance and confirm a significant role of attentional processes for sensory-motor gating. Through its influence on attention and arousal, NPS appears to positively modulate PPI in young animals, whereas compensatory mechanisms may alleviate NPS-dependent deficits in older mice.

scholarly journals Behavioral phenotyping of Neuropeptide S receptor knockout mice

2009 ◽  
Vol 205 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Dee M. Duangdao ◽  
Stewart D. Clark ◽  
Naoe Okamura ◽  
Rainer K. Reinscheid
Keyword(s):  
Knockout Mice ◽  
Neuropeptide S ◽  
Behavioral Phenotyping

Heat stable toxin of E. coli (STa) stimulates duodenal mucosal bicarbonate secretion in cystic fibrosis knockout mice

2001 ◽  
Vol 120 (5) ◽  
pp. A137-A137
Author(s):  
D CHILDS ◽  
D CROMBIE ◽  
V PRATHA ◽  
Z SELLERS ◽  
D HOGAN ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Knockout Mice ◽  
Bicarbonate Secretion ◽  
E Coli ◽  
Heat Stable

Sa1495 LEPTIN AUGMENTS BILIARY HYPERPLASIA AND HEPATIC FIBROSIS IN MDR2-KNOCKOUT MICE

2020 ◽  
Vol 158 (6) ◽  
pp. S-1310
Author(s):  
Rebekah John ◽  
Anca D. Petrescu ◽  
Stephanie Grant ◽  
Elaina Williams ◽  
Sharon DeMorrow
Keyword(s):  
Hepatic Fibrosis ◽  
Knockout Mice

Abstract #219: Evidence of Insulitis in Signal Transducer and Activator of Transcription 5 (Stat5) Knockout Mice

2017 ◽  
Vol 23 ◽  
pp. 39
Author(s):  
Aili Guo ◽  
Nigel Daniels ◽  
Craig Nunemaker ◽  
Samantha J. Shaw ◽  
Karen Coschigano
Keyword(s):  
Knockout Mice ◽  
Signal Transducer

Xpa and Xpa/p53 +/- Knockout Mice: Overview of Available Data

2001 ◽  
Vol 29 (5) ◽  
pp. 117-127 ◽  
Author(s):  
Coen F. van Kreijl ◽  
Peter A. McAnulty ◽  
Rudolf B. Beems ◽  
An Vynckier ◽  
Harry van Steeg ◽  
...  
Keyword(s):  
Knockout Mice
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