scholarly journals Myosin II activity is required for structural plasticity at the axon initial segment

2017 ◽  
Vol 46 (2) ◽  
pp. 1751-1757 ◽  
Author(s):  
Mark D. Evans ◽  
Candida Tufo ◽  
Adna S. Dumitrescu ◽  
Matthew S. Grubb
Keyword(s):  
Initial Segment ◽  
Myosin Ii ◽  
Structural Plasticity ◽  
Axon Initial Segment

scholarly journals The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

2016 ◽  
Vol 59 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Masoumeh Nozari ◽  
Toshimitsu Suzuki ◽  
Marcello G. P. Rosa ◽  
Kazuhiro Yamakawa ◽  
Nafiseh Atapour
Keyword(s):  
Initial Segment ◽  
Structural Plasticity ◽  
Axon Initial Segment ◽  
Environmental Interventions ◽  
The Impact

scholarly journals A period of structural plasticity at the axon initial segment in developing visual cortex

2014 ◽  
Vol 8 ◽  
Author(s):  
Annika Gutzmann ◽  
Nursah Ergül ◽  
Rebecca Grossmann ◽  
Christian Schultz ◽  
Petra Wahle ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Initial Segment ◽  
Structural Plasticity ◽  
Axon Initial Segment

scholarly journals Structural Plasticity of Synaptopodin in the Axon Initial Segment during Visual Cortex Development

2017 ◽  
Vol 27 (9) ◽  
pp. 4662-4675 ◽  
Author(s):  
Annabelle Schlüter ◽  
Domenico Del Turco ◽  
Thomas Deller ◽  
Annika Gutzmann ◽  
Christian Schultz ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Initial Segment ◽  
Structural Plasticity ◽  
Axon Initial Segment

scholarly journals Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment

Neuron ◽  
2018 ◽  
Vol 97 (3) ◽  
pp. 555-570.e6 ◽  
Author(s):  
Stephen L. Berger ◽  
Alejandra Leo-Macias ◽  
Stephanie Yuen ◽  
Latika Khatri ◽  
Sylvia Pfennig ◽  
...  
Keyword(s):  
Initial Segment ◽  
Myosin Ii ◽  
Axon Initial Segment

Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy

2013 ◽  
Vol 105 (3) ◽  
pp. 272-279 ◽  
Author(s):  
Rosemary C. Harty ◽  
Tae Hwan Kim ◽  
Evan A. Thomas ◽  
Lisa Cardamone ◽  
Nigel C. Jones ◽  
...  
Keyword(s):  
Animal Models ◽  
Initial Segment ◽  
Structural Plasticity ◽  
Axon Initial Segment ◽  
Acquired Epilepsy

scholarly journals Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1961
Author(s):  
Ana Rita Costa ◽  
Monica M. Sousa
Keyword(s):  
Spatial Distribution ◽  
Growth Cone ◽  
Cell Biology ◽  
Initial Segment ◽  
Current Knowledge ◽  
Myosin Ii ◽  
Axon Growth ◽  
Axon Initial Segment ◽  
And Function ◽  
Muscle Myosin

By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and motility, axon growth during development (and axon regeneration in the adult), radial and longitudinal axonal tension, and synapse formation and function. In this review, we discuss the current knowledge on the spatial distribution and function of the actomyosin cytoskeleton in different axonal compartments. We highlight some of the apparent contradictions and open questions in the field, including the role of NMII in the regulation of axon growth and regeneration, the possibility that NMII structural arrangement along the axon shaft may control both radial and longitudinal contractility, and the mechanism and functional purpose underlying NMII enrichment in the axon initial segment. With the advances in live cell imaging and super resolution microscopy, it is expected that in the near future the spatial distribution of NMII in the axon, and the mechanisms by which it participates in axonal biology will be further untangled.

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