Resting state functional connectivity measures correlate with the response to anodal transcranial direct current stimulation

2017 ◽  
Vol 45 (6) ◽  
pp. 837-845 ◽  
Author(s):  
Brenton Hordacre ◽  
Bahar Moezzi ◽  
Mitchell R. Goldsworthy ◽  
Nigel C. Rogasch ◽  
Lynton J. Graetz ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Direct Current Stimulation

scholarly journals Modulation of GABA and resting state functional connectivity by transcranial direct current stimulation

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Velicia Bachtiar ◽  
Jamie Near ◽  
Heidi Johansen-Berg ◽  
Charlotte J Stagg
Keyword(s):  
Functional Connectivity ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Resonance Spectroscopy ◽  
Resting State Functional Connectivity ◽  
Direct Current Stimulation ◽  
Motor Network ◽  
Before And After ◽  
Underlying Mechanisms

We previously demonstrated that network level functional connectivity in the human brain could be related to levels of inhibition in a major network node at baseline (<xref ref-type="bibr" rid="bib24">Stagg et al., 2014</xref>). In this study, we build upon this finding to directly investigate the effects of perturbing M1 GABA and resting state functional connectivity using transcranial direct current stimulation (tDCS), a neuromodulatory approach that has previously been demonstrated to modulate both metrics. FMRI data and GABA levels, as assessed by Magnetic Resonance Spectroscopy, were measured before and after 20 min of 1 mA anodal or sham tDCS. In line with previous studies, baseline GABA levels were negatively correlated with the strength of functional connectivity within the resting motor network. However, although we confirm the previously reported findings that anodal tDCS reduces GABA concentration and increases functional connectivity in the stimulated motor cortex; these changes are not correlated, suggesting they may be driven by distinct underlying mechanisms.

Sign in / Sign up

Export Citation Format

Share Document