Deficit in acoustic signal‐in‐noise detection in glycine receptor α3 subunit knockout mice

2017 ◽  
Vol 45 (4) ◽  
pp. 581-586 ◽  
Author(s):  
Konstantin Tziridis ◽  
Stefanie Buerbank ◽  
Volker Eulenburg ◽  
Julia Dlugaiczyk ◽  
Holger Schulze
Keyword(s):  
Acoustic Signal ◽  
Knockout Mice ◽  
Glycine Receptor ◽  
Noise Detection ◽  
Α3 Subunit

scholarly journals Control of Ethanol Sensitivity of the Glycine Receptor α3 Subunit by Transmembrane 2, the Intracellular Splice Cassette and C-Terminal Domain

2015 ◽  
Vol 353 (1) ◽  
pp. 80-90 ◽  
Author(s):  
Andrea Sánchez ◽  
Gonzalo E. Yévenes ◽  
Loreto San Martin ◽  
Carlos F. Burgos ◽  
Gustavo Moraga-Cid ◽  
...  
Keyword(s):  
Glycine Receptor ◽  
Ethanol Sensitivity ◽  
Terminal Domain ◽  
Α3 Subunit

scholarly journals Toward acoustic noise type detection based on QQ plot statistics

2017 ◽  
Vol 30 (4) ◽  
pp. 571-584 ◽  
Author(s):  
Sanja Vujnovic ◽  
Aleksandra Marjanovic ◽  
Zeljko Djurovic ◽  
Predrag Tadic ◽  
Goran Kvascev
Keyword(s):  
State Estimation ◽  
Acoustic Signal ◽  
Acoustic Noise ◽  
Thermal Power ◽  
Noise Pollution ◽  
Detection Algorithm ◽  
Noise Detection ◽  
Statistical Parameters ◽  
Industrial Environment ◽  
Stochastic Signal

Fault detection and state estimation using acoustic signals is a procedure highly affected by ambient noise. This is particularly pronounced in an industrial environment where noise pollution is especially strong. In this paper a noise detection algorithm is proposed and implemented. This algorithm can identify the times in which the recorded acoustic signal is influenced by different types of noise in the form of unwanted impulse disturbance or speech contamination. The algorithm compares statistical parameters of the recordings by generating a series of QQ plots and then using an appropriate stochastic signal analysis tools like hypothesis testing. The main purpose of this algorithm is to eliminate noisy signals and to collect a set of noise free recordings which can then be used for state estimation. The application of these techniques in a real industrial environment is extremely complex because sound contamination usually tends to be intense and nonstationary. The solution described in this paper has been tested on a specific problem of acoustic signal isolation and noise detection of a coal grinding fan mill in thermal power plant in the presence of intense contaminating sound disturbances, mainly impulse disturbance and speech contamination.

Kinetics and functional characterization of the glycine receptor α2 and α3 subunit

2007 ◽  
Vol 429 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Cornelia Heindl ◽  
Kay Brune ◽  
Bertold Renner
Keyword(s):  
Glycine Receptor ◽  
Functional Characterization ◽  
Α3 Subunit

ISDN2014_0141: Disruption of cortical circuitry development in glycine receptor alpha 2 knockout mice

2015 ◽  
Vol 47 (Part_A) ◽  
pp. 41-41
Author(s):  
Giovanni Morelli ◽  
Ariel Avila ◽  
Robert J. Harvey ◽  
B. Brône ◽  
Laurent Nguyen ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Glycine Receptor ◽  
Receptor Alpha ◽  
Cortical Circuitry

scholarly journals Kidney failure in mice lacking the tetraspanin CD151

2006 ◽  
Vol 175 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Norman Sachs ◽  
Maaike Kreft ◽  
Marius A. van den Bergh Weerman ◽  
Andy J. Beynon ◽  
Theo A. Peters ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Kidney Failure ◽  
Sensorineural Deafness ◽  
Conditional Knockout ◽  
Lateral Interaction ◽  
Cell Surface Molecule ◽  
Hearing Ability ◽  
A Cell ◽  
Α3 Subunit ◽  
End Stage

The tetraspanin CD151 is a cell-surface molecule known for its strong lateral interaction with the laminin-binding integrin α3β1. Patients with a nonsense mutation in CD151 display end-stage kidney failure associated with regional skin blistering and sensorineural deafness, and mice lacking the integrin α3 subunit die neonatally because of severe abnormalities in the lung and kidney epithelia. We report the generation of Cd151-null mice that recapitulate the renal pathology of human patients, i.e., with age they develop massive proteinuria caused by focal glomerulosclerosis, disorganization of the glomerular basement membrane, and tubular cystic dilation. However, neither skin integrity nor hearing ability are impaired in the Cd151-null mice. Furthermore, we generated podocyte-specific conditional knockout mice for the integrin α3 subunit that show renal defects similar to those in the Cd151 knockout mice. Our results support the hypothesis that CD151 plays a key role in strengthening α3β1-mediated adhesion in podocytes.

scholarly journals Disruption of cortical circuitry development in glycine receptor alpha 2 knockout mice

2015 ◽  
Vol 9 ◽  
Author(s):  
Morelli Giovanni ◽  
Avila Ariel ◽  
Aourz Najat ◽  
Smolders Ilse ◽  
Brône Bert ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Glycine Receptor ◽  
Receptor Alpha ◽  
Cortical Circuitry
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