scholarly journals Do wholes become more than the sum of their parts in the rodent (Rattus Norvegicus ) visual system? A test case with the configural superiority effect

2016 ◽  
Vol 44 (8) ◽  
pp. 2593-2599 ◽  
Author(s):  
John C. Talpos ◽  
Lee de-Wit ◽  
Joseph Olley ◽  
Jack Riordan ◽  
Thomas Steckler
Keyword(s):  
Visual System ◽  
Rattus Norvegicus ◽  
Test Case ◽  
Superiority Effect ◽  
System A ◽  
Configural Superiority Effect

scholarly journals THE VISUAL SYSTEM: A "CHICKEN AND EGG" PROBLEM SOLVED

2009 ◽  
Vol 05 (01) ◽  
pp. 115-121
Author(s):  
ANDREW R. PARKER ◽  
H. JOHN CAULFIELD
Keyword(s):  
Visual System ◽  
Neural Plasticity ◽  
Neural Circuit ◽  
Process Data ◽  
System A ◽  
New Information ◽  
The Brain

"What comes first: the chicken or the egg?" Eyes and vision were a great concern for Darwin. Recently, religious fundamentalists have started to attack evolution on the grounds that this is a chicken and egg problem. How could eyes improve without the brain module to use the new information that eye provides? But how could the brain evolve a neural circuit to process data not available to it until a new eye capability emerges? We argue that neural plasticity in the brain allows it to make use of essentially any useful information the eye can produce. And it does so easily within the animal's lifetime. Richard Gregory suggested something like this 40 years ago. Our work resolves a problem with his otherwise-insightful work.

scholarly journals Unlabeled lysophosphatidic acid receptor binding in free solution as determined by a compensated interferometric reader

2020 ◽  
Vol 61 (8) ◽  
pp. 1244-1251 ◽  
Author(s):  
Manisha Ray ◽  
Kazufumi Nagai ◽  
Yasuyuki Kihara ◽  
Amanda Kussrow ◽  
Michael N. Kammer ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Lysophosphatidic Acid ◽  
Specific Binding ◽  
Test Case ◽  
Free Solution ◽  
Label Free ◽  
Adhesive Properties ◽  
Lpa Receptor ◽  
System A ◽  
G Protein Coupled

Native interactions between lysophospholipids (LPs) and their cognate LP receptors are difficult to measure because of lipophilicity and/or the adhesive properties of lipids, which contribute to high levels of nonspecific binding in cell membrane preparations. Here, we report development of a free-solution assay (FSA) where label-free LPs bind to their cognate G protein-coupled receptors (GPCRs), combined with a recently reported compensated interferometric reader (CIR) to quantify native binding interactions between receptors and ligands. As a test case, the binding parameters between lysophosphatidic acid (LPA) receptor 1 (LPA1; one of six cognate LPA GPCRs) and LPA were determined. FSA-CIR detected specific binding through the simultaneous real-time comparison of bound versus unbound species by measuring the change in the solution dipole moment produced by binding-induced conformational and/or hydration changes. FSA-CIR identified KD values for chemically distinct LPA species binding to human LPA1 and required only a few nanograms of protein: 1-oleoyl (18:1; KD = 2.08 ± 1.32 nM), 1-linoleoyl (18:2; KD = 2.83 ± 1.64 nM), 1-arachidonoyl (20:4; KD = 2.59 ± 0.481 nM), and 1-palmitoyl (16:0; KD = 1.69 ± 0.1 nM) LPA. These KD values compared favorably to those obtained using the previous generation back-scattering interferometry system, a chip-based technique with low-throughput and temperature sensitivity. In conclusion, FSA-CIR offers a new increased-throughput approach to assess quantitatively label-free lipid ligand-receptor binding, including nonactivating antagonist binding, under near-native conditions.

An Euler Solution for Unsteady Flows Around Oscillating Blades

1990 ◽  
Vol 112 (4) ◽  
pp. 714-722 ◽  
Author(s):  
L. He
Keyword(s):  
Unsteady Flows ◽  
Nonlinear Behavior ◽  
Alternative Methods ◽  
Finite Volume Scheme ◽  
Test Case ◽  
System A ◽  
Standard Configuration ◽  
Time Marching ◽  
Grid Technique ◽  
Euler Solution

A time-marching Euler calculation for 2-D and quasi-3-D unsteady flows in oscillating blade rows is presented, based on a finite volume scheme with cell-vertex discretization in space and 2-step Runge-Kutta integration in time. Extra fluxes due to the deformation of the moving finite volumes are directly included in the conservation equations in the physical coordinate system. A zonal moving grid technique is used, in which only subregions near oscillating blades are moved to fit both the moving (blade) boundaries and fixed regions. For phase-shifted periodic conditions, the conventional “Direct Store” method is used as a basis for comparison. Two alternative methods to save computer storage are proposed and preliminary demonstrations of their usefulness are given in the present calculations. Calculated results for unsteady flows in an oscillating flat plate cascade are in good agreement with those from two well-established linear methods, LINSUB and FINEL. The unsteady pressure distribution and aerodynamic damping calculated by the present method for a turbine blade test case (Aeroelasticity Workshop Standard Configuration No. 4 cascade) agree well with the corresponding experimental data. Computations for an oscillating biconvex cascade in transonic flow conditions are performed, which show some strong nonlinear behavior of shock wave movement.

Range of Variability in the Dynamics of Semi-Cylindrical Friction Dampers for Turbine Blades

2008 ◽  
Author(s):  
Stefano Zucca ◽  
Daniele Botto ◽  
Muzio M. Gola
Keyword(s):  
Degrees Of Freedom ◽  
Turbine Blades ◽  
Numerical Test ◽  
Forced Response ◽  
Numerical Code ◽  
Test Case ◽  
Force Coefficient ◽  
System A ◽  
Flat Side ◽  
Fatigue Failures

Under-platform dampers are used to reduce resonant stresses in turbine blades to avoid high cycle fatigue failures. In this paper a model of semi-cylindrical under-platform damper (i.e. with one flat side and one curved side) for turbine blades is described. The damper kinematics is characterized by three degrees of freedom (DOFs): in-plane translations and rotation. Static normal loads acting on the damper sides are computed using the three static balance equations of the damper. Non-uniqueness of normal pre-loads acting on the damper sides is highlighted. Implementation of the model in a numerical code for the forced response calculation of turbine blades with under-platform dampers shows that non-uniqueness of normal pre-loads leads to non-uniqueness of the forced response of the system. A numerical test case is presented to show the capabilities of the model and to analyze the effect of the main system parameters (damper mass, excitation force, coefficient of friction and damper rotation) on the damper behavior and on the system dynamics.

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