Impact of neural cell adhesion molecule deletion on regeneration after mouse spinal cord injury

2016 ◽  
Vol 44 (1) ◽  
pp. 1734-1746 ◽  
Author(s):  
Vedangana Saini ◽  
Gabriele Loers ◽  
Gurcharan Kaur ◽  
Melitta Schachner ◽  
Igor Jakovcevski
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Mouse Spinal Cord ◽  
Cord Injury ◽  
Neural Cell Adhesion

scholarly journals Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture.

1983 ◽  
Vol 97 (1) ◽  
pp. 145-152 ◽  
Author(s):  
U Rutishauser ◽  
M Grumet ◽  
G M Edelman
Keyword(s):  
Spinal Cord ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Muscle Cells ◽  
Neural Cell ◽  
Antigenic Determinants ◽  
Fab Fragments ◽  
Neural Cell Adhesion

Previous studies in this laboratory have described a cell surface glycoprotein, called neural cell adhesion molecule or N-CAM, that appears to be a ligand in the adhesion between neural membranes. N-CAM antigenic determinants were also shown to be present on embryonic muscle and an N-CAM-dependent adhesion was demonstrated between retinal cell membranes and muscle cells in short-term assays. The present studies indicate that these antigenic determinants are associated with the N-CAM polypeptide, and that rapid adhesion mediated by this molecule occurs between spinal cord membranes and muscle cells. Detailed examination of the effects of anti-(N-CAM) Fab' fragments in cultures of spinal cord with skeletal muscle showed that the Fab' fragments specifically block adhesion of spinal cord neurites and cells to myotubes. The Fab' did not affect binding of neurites to fibroblasts and collagen substrate, and did not alter myotube morphology. These results indicate that N-CAM adhesion is essential for the in vitro establishment of physical associations between nerve and muscle, and suggest that binding involving N-CAM may be an important early step in synaptogenesis.

Expression of embryonic neural cell adhesion molecule (E-N-CAM) and dystrophin in regenerating tail spinal cord of amphibian urodeles

1991 ◽  
Vol 73 (2-3) ◽  
pp. 2a-2a
Author(s):  
Xavier Caubit ◽  
Jean-Pierre Arsanto ◽  
Monique Diano ◽  
Geneviève Rougon ◽  
Dominique Figarella ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Neural Cell Adhesion
Sign in / Sign up

Export Citation Format

Share Document