Model of anaesthetic induction by unilateral intracerebral microinjection of GABAergic agonists

2016 ◽  
Vol 43 (6) ◽  
pp. 846-858 ◽  
Author(s):  
Marshall Devor ◽  
Vladimir Zalkind ◽  
Yelena Fishman ◽  
Anne Minert
Keyword(s):  
Anaesthetic Induction ◽  
Intracerebral Microinjection

Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit

1981 ◽  
Vol 240 (4) ◽  
pp. F329-F336 ◽  
Author(s):  
M. W. Bradbury ◽  
H. F. Cserr ◽  
R. J. Westrop
Keyword(s):  
Cerebrospinal Fluid ◽  
Caudate Nucleus ◽  
Subarachnoid Space ◽  
Interstitial Fluid ◽  
Bulk Flow ◽  
Perivascular Spaces ◽  
Csf Analysis ◽  
Intraventricular Injections ◽  
Intracerebral Microinjection ◽  
Do So

Lymph from the jugular lymph trunks of anesthetized rabbits has been continuously collected and radioiodinated albumin (RISA) therein estimated after microinjection of 1 microliter of 131I-albumin into the caudate nucleus, after single intraventricular injections, and during intraventricular infusions. Comparison of lymph at 7 and 25 h after intracerebral microinjection with efflux of radioactivity from whole brain suggests that about 50% of cleared radioactivity goes through lymph. Concentrations, normalized to cerebrospinal fluid (CSF), were much higher in lymph and retropharyngeal nodes after brain injection than after CSF injection or infusion. Also after brain injection, lymph and nodes contained more activity on injected side in contrast to lack of laterality after CSF administration. Calculation suggests that less than 30% of RISA cleared from brain can do so via a pool of well-mixed CSF. Analysis of tissues is compatible with much RISA draining by bulk flow via cerebral perivascular spaces plus passage from subarachnoid space of olfactory lobes into submucous spaces of nose and thus to lymph.

Neural pathways associated with loss of consciousness caused by intracerebral microinjection of GABAA-active anesthetics

2007 ◽  
Vol 25 (5) ◽  
pp. 1417-1436 ◽  
Author(s):  
I. Sukhotinsky ◽  
V. Zalkind ◽  
J. Lu ◽  
D. A. Hopkins ◽  
C. B. Saper ◽  
...  
Keyword(s):  
Loss Of Consciousness ◽  
Neural Pathways ◽  
Intracerebral Microinjection

The use of mandibular nerve block to predict safe anaesthetic induction in patients with acute trismus*

Anaesthesia ◽  
2009 ◽  
Vol 64 (11) ◽  
pp. 1196-1198 ◽  
Author(s):  
A. M. B. Heard ◽  
R. J. Green ◽  
D. A. Lacquiere ◽  
P. Sillifant
Keyword(s):  
Nerve Block ◽  
Mandibular Nerve ◽  
Anaesthetic Induction

Jugular thrombophlebitis resulting from an anaesthetic induction technique in the horse

1990 ◽  
Vol 22 (3) ◽  
pp. 177-179 ◽  
Author(s):  
LINDA R. DICKSON ◽  
L. M. BADCOE ◽  
HILARY BURBIDGE ◽  
N. J. KANNEGIETER
Keyword(s):  
Anaesthetic Induction ◽  
Induction Technique

scholarly journals Effects of long periods of pneumoperitoneum combined with the head-up position on heart rate-corrected QT interval during robotic gastrectomy: an observational study

2018 ◽  
Vol 46 (11) ◽  
pp. 4586-4595
Author(s):  
Na Young Kim ◽  
Sun-Joon Bai ◽  
Hyoung-Il Kim ◽  
Jung Hwa Hong ◽  
Hoon Jae Nam ◽  
...  
Keyword(s):  
Heart Rate ◽  
Observational Study ◽  
Close Monitoring ◽  
Qtc Interval ◽  
Robotic Gastrectomy ◽  
Anaesthetic Induction ◽  
Carbon Dioxide Pneumoperitoneum ◽  
Long Duration ◽  
Haemodynamic Changes ◽  
Registration Number

Objective Pneumoperitoneum and the head-up position reportedly stimulate the sympathetic nervous system, potentially increasing the risk of cardiac arrhythmia. We evaluated the effects of a long duration of pneumoperitoneum in the head-up position on the heart rate-corrected QT (QTc) interval during robotic gastrectomy. Methods This prospective observational study involved 28 patients undergoing robotic gastrectomy. The QTc interval was recorded at the following time points: before anaesthetic induction (baseline); 10 minutes after tracheal intubation; 1, 5, 30, 60, and 90 minutes after pneumoperitoneum induction in the head-up position; after pneumoperitoneum desufflation in the supine position; and at the end of surgery. The primary outcome was the QTc interval, which was measured 90 minutes after pneumoperitoneum combined with the head-up position. Results Compared with baseline, the QTc interval was significantly prolonged at 1 and 60 minutes after pneumoperitoneum, peaked at 90 minutes, and was sustained and notably prolonged until the end of surgery. However, no considerable haemodynamic changes developed. Conclusion A long period of carbon dioxide pneumoperitoneum application in a head-up position significantly prolonged the QTc interval during robotic gastrectomy. Therefore, diligent care and close monitoring are required for patients who are susceptible to developing ventricular arrhythmia. Trial Registration: Registered at ClinicalTrials.gov; https://clinicaltrials.gov/ct2/show/NCT02604979 ; Registration number NCT02604979

Alfentanyl: A New Narcotic Anaesthetic Induction Agent

1981 ◽  
pp. 40-48
Author(s):  
J. H. Nauta ◽  
S. De Lange ◽  
D. W. Koopman ◽  
J. W. Van Kleef ◽  
Joh. Spierdijk ◽  
...  
Keyword(s):  
Induction Agent ◽  
Anaesthetic Induction

Midazolam as Anaesthetic Induction Agent

1981 ◽  
pp. 25-32
Author(s):  
J. H. Nauta ◽  
D. W. Koopman ◽  
Joh. Spierdijk ◽  
T. H. Stanley
Keyword(s):  
Induction Agent ◽  
Anaesthetic Induction
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