Peroxisome proliferator-activated receptor-γ coactivator-1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein

2016 ◽  
Vol 43 (5) ◽  
pp. 626-639 ◽  
Author(s):  
Johanna Mäkelä ◽  
Giuseppa Mudò ◽  
Dan Duc Pham ◽  
Valentina Di Liberto ◽  
Ove Eriksson ◽  
...  
Keyword(s):  
Brain Injury ◽  
Transgenic Mice ◽  
Inhibitor Of Apoptosis ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Inhibitor Of Apoptosis Protein ◽  
Apoptosis Protein

Protective role of the inhibitor of apoptosis protein, survivin, in toxin‐induced acute renal failure

2007 ◽  
Vol 22 (2) ◽  
pp. 510-521 ◽  
Author(s):  
Nele Kindt ◽  
Axel Menzebach ◽  
Marlies Van de Wouwer ◽  
Inge Betz ◽  
Astrid De Vriese ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Role ◽  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Protein ◽  
Apoptosis Protein

Role of Inhibitor of Apoptosis Protein Livin in Radiation Resistance in Nonsmall Cell Lung Cancer

2011 ◽  
Vol 26 (5) ◽  
pp. 585-592 ◽  
Author(s):  
Jian-Guo Sun ◽  
Rong-Xia Liao ◽  
Shao-Xiang Zhang ◽  
Yu-Zhong Duan ◽  
Wen-Lei Zhuo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Radiation Resistance ◽  
Nonsmall Cell Lung Cancer ◽  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Protein ◽  
Apoptosis Protein

scholarly journals Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

2009 ◽  
Vol 29 (7) ◽  
pp. 1251-1261 ◽  
Author(s):  
Juan Pablo de Rivero Vaccari ◽  
George Lotocki ◽  
Ofelia F Alonso ◽  
Helen M Bramlett ◽  
W Dalton Dietrich ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Injury ◽  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Protein ◽  
Nlrp1 Inflammasome ◽  
Caspase 1 ◽  
Fluid Percussion Injury ◽  
Apoptosis Protein

Traumatic brain injury elicits acute inflammation that in turn exacerbates primary brain damage. A crucial part of innate immunity in the immune privileged central nervous system involves production of proinflammatory cytokines mediated by inflammasome signaling. Here, we show that the nucleotide-binding, leucine-rich repeat pyrin domain containing protein 1 (NLRP1) inflammasome consisting of NLRP1, caspase-1, caspase-11, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), the X-linked inhibitor of apoptosis protein, and pannexin 1 is expressed in neurons of the cerebral cortex. Moderate parasagittal fluid-percussion injury (FPI) induced processing of interleukin-1β, activation of caspase-1, cleavage of X-linked inhibitor of apoptosis protein, and promoted assembly of the NLRP1 inflammasome complex. Anti-ASC neutralizing antibodies administered immediately after fluid-percussion injury to injured rats reduced caspase-1 activation, X-linked inhibitor of apoptosis protein cleavage, and processing of interleukin-1β, resulting in a significant decrease in contusion volume. These studies show that the NLRP1 inflammasome constitutes an important component of the innate central nervous system inflammatory response after traumatic brain injury and may be a novel therapeutic target for reducing the damaging effects of posttraumatic brain inflammation.

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