Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants

2014 ◽  
Vol 40 (10) ◽  
pp. 3538-3547 ◽  
Author(s):  
Fei Guo ◽  
Qi Zhang ◽  
Bing Zhang ◽  
Zhiwen Fu ◽  
Bin Wu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Burst Firing ◽  
Firing Patterns ◽  
Neuronal Mechanisms

scholarly journals Distributed representations of temporal stimulus associations across regular-firing and fast-spiking neurons in rat medial prefrontal cortex

2020 ◽  
Vol 123 (1) ◽  
pp. 439-450
Author(s):  
Bohan Xing ◽  
Mark D. Morrissey ◽  
Kaori Takehara-Nishiuchi
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Functional Organization ◽  
Spiking Neurons ◽  
Burst Firing ◽  
Inhibitory Neurons ◽  
Firing Patterns ◽  
Excitatory Neurons ◽  
Fast Spiking ◽  
The Difference

The prefrontal cortex has been implicated in various cognitive processes, including working memory, executive control, decision making, and relational learning. One core computational requirement underlying all these processes is the integration of information across time. When rodents and rabbits associate two temporally discontiguous stimuli, some neurons in the medial prefrontal cortex (mPFC) change firing rates in response to the preceding stimulus and sustain the firing rate during the subsequent temporal interval. These firing patterns are thought to serve as a mechanism to buffer the previously presented stimuli and signal the upcoming stimuli; however, how these critical properties are distributed across different neuron types remains unknown. We investigated the firing selectivity of regular-firing, burst-firing, and fast-spiking neurons in the prelimbic region of the mPFC while rats associated two neutral conditioned stimuli (CS) with one aversive stimulus (US). Analyses of firing patterns of individual neurons and neuron ensembles revealed that regular-firing neurons maintained rich information about CS identity and CS-US contingency during intervals separating the CS and US. Moreover, they further strengthened the latter selectivity with repeated conditioning sessions over a month. The selectivity of burst-firing neurons for both stimulus features was weaker than that of regular-firing neurons, indicating the difference in task engagement between two subpopulations of putative excitatory neurons. In contrast, putative inhibitory, fast-spiking neurons showed a stronger selectivity for CS identity than for CS-US contingency, suggesting their potential role in sensory discrimination. These results reveal a fine-scaled functional organization in the prefrontal network supporting the formation of temporal stimulus associations. NEW & NOTEWORTHY To associate stimuli that occurred separately in time, the brain needs to bridge the temporal gap by maintaining what was presented and predicting what would follow. We show that in rat medial prefrontal cortex, the former function is associated with a subpopulation of putative inhibitory neurons, whereas the latter is supported by a subpopulation of putative excitatory neurons. Our results reveal a distinct contribution of these microcircuit components to neural representations of temporal stimulus associations.

scholarly journals Electrophysiological Diversity of Layer 5 Pyramidal Cells in the Prefrontal Cortex of the Rhesus Monkey: In Vitro Slice Studies

2007 ◽  
Vol 98 (5) ◽  
pp. 2622-2632 ◽  
Author(s):  
Yu-Ming Chang ◽  
Jennifer I. Luebke
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkey ◽  
Spike Train ◽  
Pyramidal Cells ◽  
Cell Types ◽  
Dendritic Morphology ◽  
Firing Patterns ◽  
Electrophysiological Properties ◽  
Whole Cell Patch Clamp

Whole cell patch-clamp recordings were employed to characterize the electrophysiological properties of layer 5 pyramidal cells in slices of the prefrontal cortex (Area 46) of the rhesus monkey. Four electrophysiologically distinct cell types were discriminated based on distinctive repetitive action potential (AP) firing patterns and single AP characteristics: regular-spiking slowly adapting type-1 cells (RS1; 62%), regular-spiking slowly adapting type-2 cells (RS2; 18%), regular-spiking fast-adapting cells (FA; 15%), and intrinsically bursting cells (IB; 5%). These cells did not differ with regard to their location in layer 5 nor in their dendritic morphology. In RS1 cells, AP threshold and amplitude did not change significantly during a 2-s spike train, whereas in RS2 and FA cells, AP threshold increased significantly and AP amplitude decreased significantly during the train. In FA cells, complete adaptation of AP firing was observed within 600 ms. IB cells displayed an all-or-none burst of three to six APs, followed by RS1-type firing behavior. RS1 cells could be further subdivided into three subtypes. Low-threshold spiking (LTS) RS1 cells exhibited an initial doublet riding on a depolarizing potential at the onset of a spike train and a prominent depolarizing afterpotential (DAP); intermediate RS1 cells (IM) exhibited a DAP, but no initial doublet, and non-LTS RS1 cells exhibited neither a DAP nor an initial doublet. RS2 and FA cells did not exhibit a DAP or initial doublets. The distinctive firing patterns of these diverse layer 5 pyramidal cells may reflect different roles played by these cells in the mediation of subcortical neuronal activity by the dorsolateral PFC.

Lipopolysaccharide effects on neuronal activity in rat basal forebrain and hypothalamus during sleep and waking

2000 ◽  
Vol 278 (3) ◽  
pp. R620-R627
Author(s):  
Xinzheng Xi ◽  
Linda A. Toth
Keyword(s):  
Neuronal Activity ◽  
Basal Forebrain ◽  
Preoptic Area ◽  
Intraperitoneal Administration ◽  
Brain Regions ◽  
Neuronal Firing ◽  
Firing Patterns ◽  
Firing Rates ◽  
Neuronal Mechanisms ◽  
The Brain

Peripheral administration of lipopolysaccharide (LPS) is associated with alterations in sleep and the electroencephalogram. To evaluate potential neuronal mechanisms for the somnogenic effects of LPS administration, we used unanesthetized rats to survey the firing patterns of neurons in various regions of rat basal forebrain (BF) and hypothalamus during spontaneous sleep and waking and during the epochs of sleep and waking that occurred after the intraperitoneal administration of LPS. In the brain regions studied, LPS administration was associated with altered firing rates in 39% of the neurons examined. A larger proportion of LPS-responsive units showed vigilance-related alterations in firing rates compared with nonresponsive units. Approximately equal proportions of LPS-responsive neurons showed increased and decreased firing rates after LPS administration, with some units in the lateral preoptic area of the hypothalamus showing particularly robust increases. These findings are consistent with other studies showing vigilance-related changes in neuronal activity in various regions of BF and hypothalamus and further demonstrate that peripheral LPS administration alters neuronal firing rates in these structures during both sleep and waking.

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 ◽  
Vol 157 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Sumio Murase ◽  
Johan Grenhoff ◽  
Guy Chouvet ◽  
François G. Gonon ◽  
Torgny H. Svensson
Keyword(s):  
Prefrontal Cortex ◽  
Transmitter Release ◽  
Burst Firing ◽  
Dopamine Neurons ◽  
Mesolimbic Dopamine

Temperature-dependent transitions of burst firing patterns in a model pyramidal neuron

2012 ◽  
Vol 44 (4) ◽  
pp. 265-273 ◽  
Author(s):  
L. Wang ◽  
S. Liu ◽  
J. Zhang ◽  
Y. Zeng
Keyword(s):  
Pyramidal Neuron ◽  
Burst Firing ◽  
Temperature Dependent ◽  
Firing Patterns
Sign in / Sign up

Export Citation Format

Share Document