Neural oscillations during non-rapid eye movement sleep as biomarkers of circuit dysfunction in schizophrenia

2014 ◽  
Vol 39 (7) ◽  
pp. 1091-1106 ◽  
Author(s):  
Richard J. Gardner ◽  
Flavie Kersanté ◽  
Matthew W. Jones ◽  
Ullrich Bartsch
Keyword(s):  
Eye Movement ◽  
Neural Oscillations ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep

scholarly journals Alterations in sleep, sleep spindle, and EEG power in mGluR5 knockout mice

2020 ◽  
Vol 123 (1) ◽  
pp. 22-33 ◽  
Author(s):  
David D. Aguilar ◽  
Robert E. Strecker ◽  
Radhika Basheer ◽  
James M. McNally
Keyword(s):  
Eye Movement ◽  
Metabotropic Glutamate Receptor ◽  
Neural Oscillations ◽  
Alpha Power ◽  
Rapid Eye Movement ◽  
Sleep Spindle ◽  
Rapid Eye Movement Sleep ◽  
Metabotropic Glutamate ◽  
Gamma Power ◽  
Abnormal Sleep

The type 5 metabotropic glutamate receptor (mGluR5) represents a novel therapeutic target for schizophrenia and other disorders. Schizophrenia is associated with progressive abnormalities in cortical oscillatory processes including reduced spindles (8–15 Hz) during sleep and increased delta (0.5–4 Hz)- and gamma-band activity (30–80 Hz) during wakefulness. mGluR5 knockout (KO) mice demonstrate many schizophrenia-like behaviors, including abnormal sleep. To examine the effects of mGluR5 on the maintenance of the neocortical circuitry responsible for such neural oscillations, we analyzed sleep/wake electroencephalographic (EEG) activity of mGluR5 KO mice at baseline, after 6 h of sleep deprivation, and during a visual method of cortical entrainment (visual steady state response). We hypothesized mGluR5-KO mice would exhibit translationally relevant abnormalities in sleep and neural oscillations that mimic schizophrenia. Power spectral and spindle density analyses were performed across 24-h EEG recordings in mGluR5-KO mice and wild-type (WT) controls. Novel findings in mGluR5 KO mice include deficits in sleep spindle density, wake alpha power, and 40-Hz visual task-evoked gamma power and phase locking. Sigma power (10–15 Hz), an approximation of spindle activity, was also reduced during non-rapid eye movement sleep transitions. Our observations on abnormal sleep/wake are generally in agreement with previous reports, although we did not replicate changes in rapid eye movement sleep. The timing of these phenotypes may suggest an impaired circadian process in mGluR5 KO mice. In conclusion, EEG phenotypes in mGluR5 KO mice resemble deficits observed in patients with schizophrenia. These findings implicate mGluR5-mediated pathways in several translationally relevant phenotypes associated with schizophrenia, and suggest that agents targeting this receptor may have harmful consequences on sleep health and daily patterns of EEG power. NEW & NOTEWORTHY Metabotropic glutamate receptor type 5 (mGluR5) knockout (KO) mice show several translationally relevant abnormalities in neural oscillatory activity associated with schizophrenia. These include deficits in sleep spindle density, sigma and alpha power, and 40-Hz task-evoked gamma power. The timing of these phenotypes suggests an impaired circadian process in these mice. Previously reported rapid eye movement sleep deficits in this model were not observed. These findings suggest mGluR5-enhancing drugs may improve sleep stability and sleep spindle density, which could impact memory and cognition.

scholarly journals Manipulating neural activity and sleep-dependent memory consolidation

Neuroforum ◽  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Maryam Ghorbani ◽  
Lisa Marshall
Keyword(s):  
Eye Movement ◽  
Neural Activity ◽  
Memory Consolidation ◽  
Nrem Sleep ◽  
Neural Oscillations ◽  
Rapid Eye Movement ◽  
Hippocampus Dependent Memory

AbstractSleep contributes actively to the consolidation of many forms of memory. This review describes the neural oscillations of non-rapid eye movement (NREM) sleep, the structures underlying these oscillations and their relation to hippocampus-dependent memory consolidation. A main focus lies on the relation between inter- and intraregional interactions and their electrophysiological representation. Methods for modulating neural oscillations with the intent of affecting memory consolidation are presented.

scholarly journals Connectivity differences between consciousness and unconsciousness in non-rapid eye movement sleep: a TMS–EEG study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Minji Lee ◽  
Benjamin Baird ◽  
Olivia Gosseries ◽  
Jaakko O. Nieminen ◽  
Melanie Boly ◽  
...  
Keyword(s):  
Eye Movement ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep

scholarly journals Isoflurane Anesthesia Does Not Satisfy the Homeostatic Need for Rapid Eye Movement Sleep

2010 ◽  
Vol 110 (5) ◽  
pp. 1283-1289 ◽  
Author(s):  
George A. Mashour ◽  
William J. Lipinski ◽  
Lisa B. Matlen ◽  
Amanda J. Walker ◽  
Ashley M. Turner ◽  
...  
Keyword(s):  
Eye Movement ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Isoflurane Anesthesia
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