Risk of infection according to the gamma globulin level in the 100 days following allogeneic stem cell transplantations

2021 ◽  
Author(s):  
Valentin Lacombe ◽  
Christopher Nunes Gomes ◽  
Jean‐Baptiste Robin ◽  
Sylvain Thépot ◽  
Sylvie François ◽  
...  
Keyword(s):  
Stem Cell ◽  
Gamma Globulin ◽  
Risk Of Infection ◽  
Globulin Level

scholarly journals Syndrome of Hypogammaglobulinemia, Splenomegaly and Hypersplenism

Blood ◽  
1957 ◽  
Vol 12 (10) ◽  
pp. 926-932 ◽  
Author(s):  
ANANDA S. PRASAD ◽  
E. REINER ◽  
C. J. WATSON
Keyword(s):  
Hemolytic Anemia ◽  
Gamma Globulin ◽  
Reticulum Cell ◽  
Review Of The Literature ◽  
Cell Hyperplasia ◽  
Therapeutic Implications ◽  
Globulin Level ◽  
Repeated Infections ◽  
Idiopathic Hypogammaglobulinemia

Abstract Two cases of acquired idiopathic hypogammaglobulinemia associated with splenomegaly and hemolytic anemia due to hypersplenism have been reported. Splenomegaly and hypersplenism appears to be the result of reticulum cell hyperplasia caused by the lack of gamma globulin and resultant repeated infections. Both the cases had splenectomy with marked hematologic improvement. A review of the literature indicates that this syndrome is relatively common, in comparison to the incidence of total number of acquired hypogammaglobulinemia that has been reported in the literature so far. It also seems very important to recognize it because of the obvious therapeutic implications. Serum gamma globulin level should be determined in cases with unexplained hepatosplenomegaly, hypersplenism and hemolytic anemia.

scholarly journals The Serum Gamma-Globulin-Level in Malignant Disease

Nature ◽  
1956 ◽  
Vol 178 (4538) ◽  
pp. 855-855 ◽  
Author(s):  
W. GROSS ◽  
R. S. SNELL
Keyword(s):  
Malignant Disease ◽  
Gamma Globulin ◽  
Globulin Level

scholarly journals Low total gamma globulin level discovery at diffuse large B cell lymphoma diagnosis predicts high risk of infection-related death: data from a monocentric retrospective study

2021 ◽  
Author(s):  
Alexandre NGUYEN ◽  
Nicolas Martin-Silva ◽  
Hubert de Boysson ◽  
Samuel Deshayes ◽  
Anne-Claire Gac ◽  
...  
Keyword(s):  
B Cell ◽  
Gamma Globulin ◽  
Cell Lymphoma ◽  
Negative Impact ◽  
Clinical Status ◽  
B Cell Lymphoma ◽  
Globulin Level ◽  
Infectious Risk ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Objective: Diffuse-large-B-cell-lymphoma (DLBCL) can complicate B-cell-primary-immunodeficiencies (PIDs) course or induce total gamma-globulin level (TGL) lowering, whose clinical status as an effective secondary immunodeficiency (SID) remains unspecified. This study aims to assess the frequency, clinical and prognostic relevance of the lowest TGLs discovered at DLBCL diagnosis. Results: In a two year monocentric retrospective cohort, 96 patients diagnosed with DLBCL who had a serum electrophoresis (SEP) were included. Patients were divided into the lowest (L)- and the highest (H)-TGLs (TGL ≤5.5 g/L and TGL >5.5 g/L) subgroups and compared for outcomes, including fatal infectious events. In our cohort, 12 (12.5%; 8 males; median age: 68 [55—82] years) exhibited L-TGL. There was no differences regarding demographics, Ann-Arbor-lymphoma-stages, inflammatory parameters or chemotherapy regimen between both groups. However, overall (10/12, 83.3% versus 22/96, 26.2%; p=0.03) and infection-related death rates (10/12, 83% versus 6/96, 6.2%; p<0.001) were significantly higher in the L-TGL group. Conclusion: We demonstrate for the first time the strong negative impact of L-TGL on overall and infection-related mortality in DLBCL. Prospective studies should distinguish DLBCL-related SIDs from preexisting humoral PIDs, using biomolecular testing and post-treatment TGLs monitoring to determine the best management strategy for infectious risk during DLBCL treatment in L-TGL context.

scholarly journals Dietary Tryptophan and Blood Gamma-globulin Level

1966 ◽  
Vol 90 (3) ◽  
pp. 245-248 ◽  
Author(s):  
Tatsuo Koyanagi ◽  
Kozo Ishiguro
Keyword(s):  
Gamma Globulin ◽  
Globulin Level

CD23 Antigen Density is Related to Serum Gamma Globulin Level, Bone Marrow Reticulin Pattern, and Treatment in B Chronic Lymphocytic Leukemia

1994 ◽  
Vol 13 (1-2) ◽  
pp. 89-94 ◽  
Author(s):  
Thierry Lavabre-Bertrand ◽  
Carole Exbrayat ◽  
Pascal Bourquard ◽  
Christine Lavabre-Bertrand ◽  
Nathalie Fégueux ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chronic Lymphocytic Leukemia ◽  
Gamma Globulin ◽  
Lymphocytic Leukemia ◽  
Globulin Level
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