scholarly journals Characteristics of peripheral blood differential counts in hospitalized patients with COVID‐19

2020 ◽  
Vol 105 (6) ◽  
pp. 773-778 ◽  
Author(s):  
Irene S. Pakos ◽  
Kevin Bryan Lo ◽  
Grace Salacup ◽  
Jerald Pelayo ◽  
Ruchika Bhargav ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Hospitalized Patients ◽  
Differential Counts

scholarly journals On the Origin of Peritoneal Fluid Cells

Blood ◽  
1964 ◽  
Vol 23 (1) ◽  
pp. 18-26 ◽  
Author(s):  
JOAN WRIGHT GOODMAN
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Peritoneal Fluid ◽  
Fetal Liver ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Free Cells ◽  
Donor Type ◽  
Hemopoietic Tissue ◽  
Differential Counts

Abstract Peritoneal fluid cells from mouse radiation chimeras were tested to determine their strain of origin by reaction with donor-specific and host-specific isoimmune sera. In all chimeras that retained donor hemopoietic grafts, peritoneal fluid cells were found to be of donor type. This was true regardless of the kind of hemopoietic tissue transplanted into the irradiated mouse. Donor hemopoietic transplant material included bone marrow, fetal liver, peripheral blood leukocytes, and peritoneal fluid cells from mice and bone marrow from rats. Irritation of the peritoneal cavity shifted differential counts but did not change the cytotoxicity results: all the free cells removed were of donor type.

scholarly journals Effects of Homozygosity of the nude (rnu) gene in an inbred strain of rats: Studies of lymphoid and non-lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer

1984 ◽  
Vol 18 (1) ◽  
pp. 7-14 ◽  
Author(s):  
H. P. Hougen ◽  
B. Klausen
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Genetic Background ◽  
Early Stage ◽  
Age Groups ◽  
Lymphoid Organs ◽  
Thymic Tissue ◽  
Nude Rats ◽  
Histological Appearance ◽  
Differential Counts

Several age groups of nude homozygous rnu/rnu and heterozygous rnu/+ rats of the same genetic background at an early stage of back-crossing (LEW/Mol) were compared as to body and organ weights, histological appearance and cell density of lymphoid organs, haematological values and differential counts of bone marrow and peripheral blood. No thymic tissue was found in the nude animals. 7-week-old nudes were smaller than control animals and had relatively larger non-lymphoid organs and cell-depleted peripheral lymphoid organs. Other age groups showed little difference. Peripheral blood of nude rats showed no signs of lymphopaenia in contrast with the findings in nude mice. The number of thoracic duct lymphocytes was, however, significantly smaller in all age groups of the nude rats, and the bone marrow tended to contain fewer lymphocytes.

Evaluation of an Automated Digital Imaging System, Nextslide Digital Review Network, for Examination of Peripheral Blood Smears

2012 ◽  
Vol 136 (6) ◽  
pp. 660-667 ◽  
Author(s):  
Hongbo Yu ◽  
Chi Young Ok ◽  
Adam Hesse ◽  
Peter Nordell ◽  
Diane Connor ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Digital Imaging ◽  
Peripheral Blood ◽  
Imaging System ◽  
Excellent Correlation ◽  
Nucleated Red Blood Cells ◽  
Blood Smears ◽  
Peripheral Blood Smears ◽  
Differential Counts

Context.—Several automated digital imaging systems have been introduced in recent years to improve turnaround time and proficiency in examining peripheral blood smears in hematology laboratories. Objective.—To evaluate a new automated digital imaging system, Nextslide Digital Review Network (Nextslide), for examination of peripheral blood smears. Design.—We evaluated 479 peripheral blood smears, of which 247 (51.6%) were included for comparison of Nextslide and manual white blood cell differential counts and morphology evaluation, 204 (42.6%) were included for comparison of Nextslide and CellaVision (DM96) differential counts, and 28 (5.8%) were neonatal samples examined for enumeration of nucleated red blood cells. Results.—Results from both method comparisons showed excellent correlation for all major white blood cell classes with correlation coefficients ranging from 0.70 to 0.99. Evaluation of white blood cell, red blood cell, and platelet morphology also showed good correlation among methods. White blood cell preclassification capability in the system was evaluated for rate and accuracy. Leukopenic samples demonstrated markedly decreased review time with Nextslide. Enumeration of nucleated red blood cells showed good correlation among methods. Conclusions.—Our evaluation of Nextslide shows excellent correlation when compared with conventional manual differentials and CellaVision (DM96) differentials for evaluation of peripheral blood smears.

CONGENITAL HYPOPLASTIC ANEMIA

PEDIATRICS ◽  
1954 ◽  
Vol 13 (3) ◽  
pp. 218-226
Author(s):  
E. OMER BURGERT ◽  
ROGER L. J. KENNEDY ◽  
GERTRUDE L. PEASE
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Myeloid Cells ◽  
Familial Incidence ◽  
Platelet Counts ◽  
Leukocyte Counts ◽  
The Mean ◽  
Differential Counts ◽  
Hypoplastic Anemia

Peripheral blood values and the results of bone marrow studies in 12 children suffering from congenital hypoplastic anemia are presented. In these cases the erythrocyte counts were more than 1,000,000 cells below normal, the values for hemoglobin were more than 1 gm. below normal, and the total leukocyte counts were within the range of normal except in two cases. The differential leukocyte counts showed lymphocytosis (50 to 90.5%). The mean percentage for reticulocytes was 0.3, and the platelet counts ranged from 71,000 to 409,000, except in two instances. Studies of bone marrow concentrations in six children showed a decreased myeloiderythroid layer. In 10 children differential counts of 1,000 nucleated cells in the marrow showed decrease of the percentages for normoblasts, with a range from 1.2 to 13.8 and a mean of 3.7. Myelopoiesis was fairly active, percentages for myeloid cells ranging from 32.5 to 63.4 with a mean of 46.4. The percentages for lymphocytes were increased with a range from 30.6 to 63.6 and a mean of 48.5. Maturation of the normoblasts blasts was arrested at the polychromatic stage. The myeloid-erythroid ratio was greatly increased, with a range from 4:1 to 43:1 and a mean of 19:1. In the 12 children of this series the onset was before 15 months of age. There was a familial incidence of the disease in three cases. The anemia recurred every 3 to 8 weeks as long as the hypoplasia persisted, and transfusions provided the only means of controlling the anemic state. Nevertheless, most of these children grew, developed normally, and carried on normal activities. Sponstaneous remissions occurred in five. The duration of these remissions at the time of the last reports ranged from 20 months to approximately 8 years.

scholarly journals Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions

1987 ◽  
Vol 21 (4) ◽  
pp. 342-347 ◽  
Author(s):  
B. Klausen ◽  
H. P. Hougen
Keyword(s):  
Bone Marrow ◽  
Body Weight ◽  
Cell Density ◽  
Peripheral Blood ◽  
Lymphoid Organs ◽  
Lower Body ◽  
Quantitative Studies ◽  
Lower Body Weight ◽  
Histological Appearance ◽  
Differential Counts

Four groups of inbred male LEW rats were examined: A, germfree athymic; B, specified pathogen free (SPF) athymic; C, germfree euthymic; D, SPF euthymic. All animals were killed at 18 weeks and compared with respect to body weight, histological appearance and cell density of the lymphoid organs, haematological values and differential counts of bone marrow, peripheral blood and lymph. Athymic rats had a lower body weight, less densely populated lymphoid organs, and fewer lymphocytes in the blood and lymph compared with euthymic animals. No difference was seen between athymic rats under germfree and SPF conditions, and in general the differences between athymic and euthymic animals were less pronounced under germfree conditions.

scholarly journals Characteristics of in peripheral blood of 70 hospitalized patients and 8 diarrhea patients with COVID-19

2020 ◽  
Vol 17 (9) ◽  
pp. 1142-1146
Author(s):  
Xiao-Yu Wei ◽  
Ding Jing ◽  
Bei Jia ◽  
Qing Li ◽  
Xia-Qia Zhou ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Hospitalized Patients

scholarly journals Blood eosinophil levels and prognosis of hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease

2020 ◽  
Author(s):  
Songsong Yu ◽  
Jie Zhang ◽  
Qiuhong Fang ◽  
Zhaohui Tong
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Acute Exacerbation ◽  
Peripheral Blood ◽  
Hospitalized Patients ◽  
Chronic Obstructive ◽  
Blood Eosinophil ◽  
Obstructive Pulmonary Disease ◽  
Systemic Glucocorticoids ◽  
Duration Of Hospitalization ◽  
Eosinophil Counts

Abstract Background: Studies about the clinical significance of high eosinophil levels in chronic obstructive pulmonary disease (COPD) are conflicting, and it has been less studied in hospitalized patients with acute exacerbation of COPD (AECOPD).This study was to examine blood eosinophil levels in relation to the prognosis of hospitalized patients with AECOPD.Methods: This was a retrospective cohort study of patients with AECOPD as their primary diagnosis and admitted to Beijing Shijitan Hospital, Capital Medical University, from January 2010 to December 2016. The patients were assigned according to the proportion and count of eosinophil in peripheral blood at their first hospitalization. Patients were grouped as ≤100, 100-300, and ≥300 eosinophils/µL of peripheral blood. The use of glucocorticoids, duration of hospitalization, in-hospital mortality, and re-hospitalization were examined.Results: Compared with the 100-300 eosinophils/µL group, the ≤100 eosinophils/µL group showed higher frequencies of fever, respiratory failure, and the use of systemic glucocorticoids. Eosinophil counts were not associated with in-hospital mortality and duration of hospitalization. The multivariable analysis showed that GOLD3/4 (odds ratio (OR)=2.04, 95%CI: 1.20-3.44, P=0.008), neutrophil count (OR=1.21, 95%CI: 1.03-1.41, P=0.019), systemic glucocorticoids (OR=1.84, 95%CI: 1.41-2.98, P=0.012), mechanical ventilation (OR=2.66, 95%CI: 1.36-5.18, P=0.004), and acute exacerbation in the past year before hospitalization (OR=2.03, 95%CI: 1.27-3.23, P=0.003) were independently associated with acute exacerbation within 1 year after discharge. Eosinophil count was not associated with acute exacerbation within 1 year after discharge.Conclusion: Peripheral blood eosinophil counts are not associated with the 1-year AECOPD prognosis.

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