scholarly journals A French observational study describing the use of human polyvalent immunoglobulins in hematological malignancy-associated secondary immunodeficiency

2018 ◽  
Vol 101 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Omar Benbrahim ◽  
Jean-François Viallard ◽  
Sylvain Choquet ◽  
Bruno Royer ◽  
Frédéric Bauduer ◽  
...  
Keyword(s):  
Observational Study ◽  
Hematological Malignancy ◽  
Secondary Immunodeficiency ◽  
Polyvalent Immunoglobulins

scholarly journals The Symptom Burden of Patients with Hematological Malignancy: A Cross-Sectional Observational Study

2011 ◽  
Vol 42 (3) ◽  
pp. 432-442 ◽  
Author(s):  
Vanessa Manitta ◽  
Rachel Zordan ◽  
Merrole Cole-Sinclair ◽  
Harshal Nandurkar ◽  
Jennifer Philip
Keyword(s):  
Observational Study ◽  
Hematological Malignancy ◽  
Symptom Burden ◽  
Cross Sectional

scholarly journals Outcomes and Risk Factors of Critically Ill Patients with Hematological Malignancy. Prospective Single-Centre Observational Study

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1317
Author(s):  
Šarūnas Judickas ◽  
Raimundas Stasiūnaitis ◽  
Andrius Žučenka ◽  
Tadas Žvirblis ◽  
Mindaugas Šerpytis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Observational Study ◽  
Hematological Malignancy ◽  
Invasive Mechanical Ventilation ◽  
Central Line ◽  
Arterial Line ◽  
Icu Mortality ◽  
Logistic Regression Models ◽  
Informed Consent Form

Background and Objectives: Oncohematological patients have a high risk of mortality when they need treatment in an intensive care unit (ICU). The aim of our study is to analyze the outcomes of oncohemathological patients admitted to the ICU and their risk factors. Materials and Methods: A prospective single-center observational study was performed with 114 patients from July 2017 to December 2019. Inclusion criteria were transfer to an ICU, hematological malignancy, age >18 years, a central line or arterial line inserted or planned to be inserted, and a signed informed consent form. Univariate and multivariable logistic regression models were used to evaluate the potential risk factors for ICU mortality. Results: ICU mortality was 44.74%. Invasive mechanical ventilation in ICU was used for 55.26% of the patients, and vasoactive drugs were used for 77.19% of patients. Factors independently associated with it were qSOFA score ≥2, increase of SOFA score over the first 48 h, mechanical ventilation on the first day in ICU, need for colistin therapy, lower arterial pH on arrival to ICU. Cut-off value of the noradrenaline dose associated with ICU mortality was 0.21 μg/kg/min with a ROC of 0.9686 (95%CI 0.93–1.00, p < 0.0001). Conclusions: Mortality of oncohematological patients in the ICU is high and it is associated with progression of organ dysfunction over the first 48 h in ICU, invasive mechanical ventilation and need for relatively low dose of noradrenaline. Despite our findings, we do not recommend making decisions regarding treatment limitations for patients who have reached cut-off dose of noradrenaline.

scholarly journals Case Report: Acquired Disseminated BCG in the Context of a Delayed Immune Reconstitution After Hematological Malignancy

2021 ◽  
Vol 12 ◽  
Author(s):  
Vincent Gies ◽  
Yannick Dieudonné ◽  
Florence Morel ◽  
Wladimir Sougakoff ◽  
Raphaël Carapito ◽  
...  
Keyword(s):  
Inborn Error ◽  
Immune Reconstitution ◽  
Hematological Malignancy ◽  
Bacillus Calmette Guerin ◽  
Secondary Immunodeficiency ◽  
Intravesical Bcg ◽  
Acquired Immunodeficiency ◽  
Laboratory Investigations ◽  
Unusual Situation ◽  
Bcg Instillation

ContextDisseminated infections due to Mycobacterium bovis Bacillus Calmette-Guérin (BCG) are unusual and occur mostly in patients with inborn error of immunity (IEI) or acquired immunodeficiency. However, cases of secondary BCGosis due to intravesical BCG instillation have been described. Herein, we present a case of severe BCGosis occurring in an unusual situation.Case DescriptionWe report one case of severe disseminated BCG disease occurring after hematological malignancy in a 48-year-old man without BCG instillation and previously vaccinated in infancy with no complication. Laboratory investigations demonstrated that he was not affected by any known or candidate gene of IEI or intrinsic cellular defect involving IFNγ pathway. Whole genome sequencing of the BCG strain showed that it was most closely related to the M. bovis BCG Tice strain, suggesting an unexpected relationship between the secondary immunodeficiency of the patient and the acquired BCG infection.ConclusionThis case highlights the fact that, in addition to the IEI, physicians, as well as microbiologists and pharmacists should be aware of possible acquired disseminated BCG disease in secondary immunocompromised patients treated in centers that administrate BCG for bladder cancers.

A summertime pause in immunoglobulin replacement therapy: a prospective real-world analysis

Immunotherapy ◽  
2021 ◽  
Author(s):  
Victor Hémar ◽  
Etienne Rivière ◽  
Carine Greib ◽  
Irène Machelart ◽  
Manon Roucoules ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Observational Study ◽  
Replacement Therapy ◽  
Risk Of Infection ◽  
Single Center ◽  
Secondary Immunodeficiency ◽  
Immunoglobulin Replacement Therapy ◽  
Immunoglobulin Replacement ◽  
Single Center Observational Study

Aim: To describe the effects of a summertime pause (SP) in immunoglobulin replacement therapy (IgRT). Patients & methods: We conducted a prospective single-center observational study, including 44 patients undergoing intravenous IgRT between May and June 2019 in a French teaching hospital. Results: IgRT was interrupted in 23 patients from June to October. Patients who underwent an SP were older, more likely to have secondary immunodeficiency (SID) and received lower doses of immunoglobulin and more antibiotics during winter. Most patients who did not undergo an SP had severe primary immunodeficiency. The SP did not increase the risk of infection, improved the quality of life and reduced treatment costs. Conclusion: SP in IgRT is a safe practice and should be considered for patients with mild SID.

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