Retrospective study on the incidence and outcome of proven and probable invasive fungal infections in high-risk pediatric onco-hematological patients

2017 ◽  
Vol 99 (3) ◽  
pp. 240-248 ◽  
Author(s):  
Simone Cesaro ◽  
Gloria Tridello ◽  
Elio Castagnola ◽  
Elisabetta Calore ◽  
Francesca Carraro ◽  
...  
Keyword(s):  
Retrospective Study ◽  
High Risk ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Hematological Patients

scholarly journals A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kátia Cristina Dantas ◽  
Thais Mauad ◽  
Carmen D. Saldiva de André ◽  
Ana Luiza Bierrenbach ◽  
Paulo Hilário Nascimento Saldiva
Keyword(s):  
Retrospective Study ◽  
Essential Role ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Single Centre ◽  
Historical Trends ◽  
Aids Pandemic ◽  
History Of ◽  
Frequent Infection ◽  
Over Time

AbstractAutopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of fungal infections in autopsies. Here, we analyse available data on fungal infections obtained from autopsy reports during 85 years of autopsies performed by the largest autopsy service in Brazil. All invasive fungal infections presented in autopsy reports between 1930 and 2015 were included. Of the 158,404 autopsy reports analysed, 1096 involved invasive fungal infections. In general, paracoccidioidomycosis (24%) was the most frequent infection, followed by candidiasis (18%), pneumocystosis (11.7%), cryptococcosis (11%), aspergillosis (11%) and histoplasmosis (3.8%). Paracoccidioidomycosis decreased after the 1950s, whereas opportunistic fungal infections increased steadily after the 1980s during the peak of the AIDS pandemic. The lung was the most frequently affected organ (73%). Disseminated infection was present in 64.5% of cases. In 26% of the 513 cases for which clinical charts were available for review, the diagnosis of opportunistic fungal infections was performed only at autopsy. Our unique 85-year history of autopsies showed a transition from endemic to opportunistic fungal infections in São Paulo, Brazil, reflecting increased urbanization, the appearance of novel diseases, such as AIDS in the 1980s, and advances in medical care over time.

scholarly journals Risk of invasive fungal infections in patients with high‐risk MDS and AML receiving hypomethylating agents

2020 ◽  
Vol 95 (7) ◽  
pp. 792-798
Author(s):  
Gee Youn (Geeny) Kim ◽  
Jonathan Burns ◽  
Craig W. Freyer ◽  
Keith W. Hamilton ◽  
Noelle V. Frey ◽  
...  
Keyword(s):  
High Risk ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Hypomethylating Agents

scholarly journals Isavuconazole—Animal Data and Clinical Data

2020 ◽  
Vol 6 (4) ◽  
pp. 209
Author(s):  
Livio Pagano ◽  
Chiara Cattaneo ◽  
Martina Quattrone ◽  
Margherita Oberti ◽  
Maria Mazzitelli ◽  
...  
Keyword(s):  
Clinical Data ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Hematological Patients ◽  
Animal Data

The treatment of invasive fungal infections has deeply evolved in the last years with the inclusion of new antifungals, mainly new azoles (i.e., posaconazole, isavuconazole), to the therapeutic armamentarium. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections both in animals and humans (hematological and non-hematological patients).

Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients

2009 ◽  
Vol 66 (19) ◽  
pp. 1711-1717 ◽  
Author(s):  
Joseph Menzin ◽  
Juliana L. Meyers ◽  
Mark Friedman ◽  
John R. Perfect ◽  
Amelia A. Langston ◽  
...  
Keyword(s):  
High Risk ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
High Risk Patients ◽  
Risk Patients ◽  
Length Of Hospitalization
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