Successful targeted treatment of mast cell activation syndrome with tofacitinib

2017 ◽  
Vol 99 (2) ◽  
pp. 190-193 ◽  
Author(s):  
Lawrence B. Afrin ◽  
Roger W. Fox ◽  
Susan L. Zito ◽  
Leo Choe ◽  
Sarah C. Glover
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Targeted Treatment ◽  
Mast Cell Activation ◽  
Mast Cell Activation Syndrome ◽  
Activation Syndrome

Depression, psychosocial correlates, and psychosocial resources in individuals with mast cell activation syndrome

2021 ◽  
pp. 135910532110145
Author(s):  
Jennifer Nicoloro SantaBarbara ◽  
Marci Lobel
Keyword(s):  
Mast Cell ◽  
Depressive Symptoms ◽  
Cell Activation ◽  
Physical Symptoms ◽  
Mast Cell Activation ◽  
Emotional States ◽  
Mast Cell Activation Syndrome ◽  
Disease Experience ◽  
Clinically Significant ◽  
Activation Syndrome

Individuals with Mast Cell Activation Syndrome (MCAS), a rare chronic disease, experience unpredictable physical symptoms and diagnostic challenges resulting in poor emotional states. The prevalence and correlates of depressive symptoms were examined among 125 participants who completed the CES-D and relevant instruments. The majority reported a clinically-significant level of depression which was especially common among younger participants and those who reported greater loneliness or more disease-specific stressors. Greater magnitude of depressive symptoms was associated with greater illness intrusiveness, less social support, and lower optimism. Results highlight the value of interventions targeting loneliness and stressors unique to this population.

P159 MAST CELL ACTIVATION SYNDROME AND MANAGEMENT OF ITS PROTEAN MANIFESTATIONS

2021 ◽  
Vol 127 (5) ◽  
pp. S49
Author(s):  
M. Hakim ◽  
D. Kurian ◽  
U. Rehman ◽  
S. Kazmi ◽  
A. Ghazi
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Mast Cell Activation Syndrome ◽  
Activation Syndrome

Adult-Onset Mast Cell Activation Syndrome Following Scombroid Poisoning a case report and review of the literature

2021 ◽  
Author(s):  
Isabelle Brock ◽  
Nicole Eng ◽  
Anne Maitland
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Psychiatric Symptoms ◽  
Adult Population ◽  
Relevant Literature ◽  
Mast Cell Activation ◽  
Response To Treatment ◽  
Adult Onset ◽  
Mast Cell Activation Syndrome ◽  
Activation Syndrome

Abstract Mast Cell Activation syndrome (MCAS) is a clinical condition, defined by the combination of 1) typical symptoms, 2) laboratory abnormalities and 3) response to treatment. Patients present with episodic symptoms of aberrant mast cell activation, such as abdominal cramping, asthma, hypotensive episodes, tachycardia, anaphylaxis, unexplained arrhythmias, and neurologic/psychiatric symptoms. Both clonal and nonclonal mast cell activation syndromes have been described, with a greater prevalence of non-clonal MCAS among the pediatric and adult population. Numerous extrinsic triggers of mast cell activation (MCA) are described, but recent reports point to nonatopic triggers, as the predominant, extrinsic stimulants of MCA in the adult population. The etiology of MCAS is unclear, though recent studies point to the disruption of the epithelium by infection, toxic exposures or physical trauma, and perturbation the tight regulation of these innate immune cells, associated to the epithelial borders. Here we describe a geriatric patient with adult onset MCAS, following a significant toxic exposure, scombroid poisoning. We also review the relevant literature regarding MCAS diagnosis and management as well as potential mechanisms for this hypersensitivity syndrome in adults.

Case 73: Dysautonomia Due to Mast Cell Activation Syndrome or Psoriatic Arthritis?

2019 ◽  
pp. 374-377
Author(s):  
Peter Novak
Keyword(s):  
Mast Cell ◽  
Psoriatic Arthritis ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Food Allergies ◽  
Postural Tachycardia Syndrome ◽  
Mast Cell Activation Syndrome ◽  
Autonomic Testing ◽  
Postural Tachycardia ◽  
Activation Syndrome

The patient presents with fatigue, postprandial nausea, diarrhea, food allergies, and nighttime tachycardia. She was diagnosed with mast cell syndrome (MCAS). Autonomic testing has shown anxiety; mild postural tachycardia syndrome (POTS), neuropathic form; and small fiber neuropathy, mixed, length-dependent.

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