Long-term follow-up study of porcine anti-human thymocyte immunoglobulin therapy combined with cyclosporine for severe aplastic anemia

2015 ◽  
Vol 96 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Miao Chen ◽  
Chao Liu ◽  
Junling Zhuang ◽  
Nong Zou ◽  
Ying Xu ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Immunoglobulin Therapy ◽  
Severe Aplastic Anemia ◽  
Follow Up Study ◽  
Human Thymocyte ◽  
Long Term Follow Up

scholarly journals High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up

Blood ◽  
2010 ◽  
Vol 115 (11) ◽  
pp. 2136-2141 ◽  
Author(s):  
Robert A. Brodsky ◽  
Allen R. Chen ◽  
Donna Dorr ◽  
Ephraim J. Fuchs ◽  
Carol Ann Huff ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Aplastic Anemia ◽  
Severe Aplastic Anemia ◽  
High Dose ◽  
Actuarial Survival ◽  
Free Survival ◽  
Long Term Follow Up ◽  
Treatment Naïve

Abstract Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder that can be treated with bone marrow transplantation, immunosuppressive therapy, and high-dose cyclophosphamide. Here, we report long-term follow-up on 67 SAA patients (44 treatment-naive and 23 refractory) treated with high-dose cyclophosphamide. At 10 years, the overall actuarial survival was 88%, the response rate was 71% with the majority being complete, and the actuarial event-free survival was 58% in 44 treatment-naive SAA patients. Patients with refractory SAA fared less well after high-dose cyclophosphamide therapy; at 10 years, overall actuarial survival, response, and actuarial event-free survival rates were 62%, 48%, and 27%, respectively. High-dose cyclophosphamide is highly effective therapy for severe aplastic anemia. Large randomized controlled trials will be necessary to establish how results of high-dose cyclophosphamide compare with either bone marrow transplantation or standard immunosuppressive regimens, such as antithymocyte globulin and cyclosporine.

Long-term follow-up of a novel immunosuppressive strategy of cyclosporine alternatively combined with levamisole for severe aplastic anemia

2020 ◽  
Vol 99 (8) ◽  
pp. 1727-1734
Author(s):  
Jiali Huo ◽  
Xingxin Li ◽  
Yingqi Shao ◽  
Xiang Ren ◽  
Meili Ge ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Severe Aplastic Anemia ◽  
Long Term Follow Up

733: The Prognostic Value of E-Cadherin, Alpha-, and Beta-Catenin in Invasive Bladder Cancer Patients: Long Term Follow-Up Study

2004 ◽  
Vol 171 (4S) ◽  
pp. 194-195
Author(s):  
Kyoichi Tomita ◽  
Haruki Kume ◽  
Keishi Kashibuchi ◽  
Satoru Muto ◽  
Shigeo Horie ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Invasive Bladder Cancer ◽  
Beta Catenin ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
E Cadherin
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