Serum cystatin C and serum and urine NGAL in the kidney function assessment of patients with MGUS

2014 ◽  
Vol 94 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Agnieszka Stelmach-Goldys ◽  
Bozena Czarkowska-Paczek ◽  
Aleksandra Wyczalkowska-Tomasik ◽  
Leszek Paczek
Keyword(s):  
Kidney Function ◽  
Cystatin C ◽  
Urine Ngal ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Function Assessment ◽  
Serum And Urine

scholarly journals Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Agnieszka Żyłka ◽  
Paulina Dumnicka ◽  
Beata Kuśnierz-Cabala ◽  
Agnieszka Gala-Błądzińska ◽  
Piotr Ceranowicz ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Cystatin C ◽  
Tubular Damage ◽  
Creatinine Ratio ◽  
Urine Ngal ◽  
Early Assessment ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Serum And Urine

Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. Our aim was to evaluate selected laboratory markers of glomerular and tubular damage in T2DM patients with early stages of chronic kidney disease (G1/G2, A1/A2) for their associations with A2 albuminuria and early decline in the estimated glomerular filtration rate (eGFR). Among 80 T2DM patients with median eGFR of 92.4 ml/min/1.73 m2 and median urinary albumin to creatinine ratio (uACR) of 4.69 mg/g, 19 had uACR > 30 mg/g (A2). Higher serum cystatin C, serum and urine neutrophil gelatinase associated lipocalin (NGAL), urine kidney injury molecule 1 (KIM-1), detectable urine transferrin and IgG, and lower serum uromodulin significantly predicted A2 albuminuria, urine KIM-1/creatinine ratio, and IgG being the best predictors. Albuminuria, urine NGAL/creatinine, and IgG correlated with diabetes duration. Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control. In a subgroup of 29 patients, retrospective data were available on changes in eGFR and uACR over one year. Decline in eGFR was observed in 17 patients and increase in uACR in 10 patients. Serum and urine NGAL correlated with eGFR changes. Higher urine NGAL, KIM-1/creatinine ratio, and detectable IgG were significantly associated with the increase in uACR. Widely available markers, serum cystatin C, urine IgG, transferrin, and NGAL, may help in early assessment of kidney disease in T2DM patients; however, large prospective studies are needed to confirm the conclusion.

scholarly journals Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Moses Temidayo Abiodun ◽  
Nosakhare J. Iduoriyekemwen ◽  
Phillip O. Abiodun
Keyword(s):  
Kidney Disease ◽  
Hiv Infection ◽  
Kidney Function ◽  
Cystatin C ◽  
Mean Value ◽  
Control Group ◽  
Healthy Children ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
The Mean

Background. Human immunodeficiency virus (HIV) is now a confirmed risk factor for kidney disease with an increased burden in persons of African descent.Method. We measured the serum cystatin C levels of 205 ART-naive, HIV-infected children by an ELISA technique and compared them with the levels of apparently healthy children.Result. The mean ± SD serum cystatin C level of children with HIV infection was 1.01 ± 0.44 mg/L, significantly higher than the mean value in the control group, that is, 0.72 ± 0.20 mg/L (P=0.000). The mean ± SD cystatin C-based estimated GFR of children with HIV infection was 102.7 ± 31.0 mL/min/1.73 m2, significantly lower than 126.9 ± 28.5 mL/min/1.73 m2in the control group, (P=0.014). A significantly higher proportion of HIV-infected children compared to controls had eGFR < 90 mL/min/1.73 m2(21.5% versus 5.4%;P=0.00). The prevalence of chronic kidney disease (CKD) among the HIV-infected children was 10.7%. The cystatin C-based eGFR of the HIV-infected children ≥5 years old correlated positively with their CD4 count (r=0.23;  P=0.022).Conclusion. There is a high prevalence of CKD among HIV-infected children, requiring regular monitoring of their kidney function using a cystatin C-based method.

UP-01.164 Serum Cystatin C: A Marker of Early Kidney Function Damage After Tumor Nephrectomy?

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S241
Author(s):  
M. Schmid ◽  
W. Tenschert ◽  
B. Schwaiger ◽  
F. Chun ◽  
M. Fisch
Keyword(s):  
Kidney Function ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Tumor Nephrectomy

scholarly journals Serum Creatinine and Serum Cystatin C are Both Relevant Renal Markers to Estimate Vancomycin Clearance in Critically Ill Neonates

2021 ◽  
Vol 12 ◽  
Author(s):  
Stéphanie Leroux ◽  
Valérie Biran ◽  
John van den Anker ◽  
Verena Gotta ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Intensive Care ◽  
Serum Creatinine ◽  
Kidney Function ◽  
Cystatin C ◽  
Therapeutic Drug ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Final Model ◽  
Model Based

Purpose: Serum creatinine (SCr) is used as a marker of kidney function to guide dosing of renally eliminated drugs. Serum Cystatin C (S-CysC) has been suggested as a more reliable kidney marker than SCr in adults and children. Purpose of this study was to investigate S-CysC as alternative renal marker to SCr for estimating vancomycin clearance in neonates undergoing intensive care.Methods: Vancomycin pharmacokinetics (PK), SCr and S-CysC data were collected in patients undergoing vancomycin treatment in the neonatal intensive care unit of Robert Debré Hospital - Paris. A population PK analysis was performed utilizing routine therapeutic drug monitoring samples. S-CysC and SCr were compared as covariates on vancomycin clearance using stepwise covariate modeling (forward inclusion [p &lt; 0.05] and backward elimination [p &lt; 0.01]). Model performance was evaluated by graphical and statistical criteria.Results: A total of 108 vancomycin concentrations from 66 patients (postmenstrual age [PMA] of 26–46 weeks) were modeled with an allometric one-compartment model. The median (range) values for SCr and S-CysC were 41 (12–153) µmol/l and 1.43 (0.95–2.83) mg/l, respectively. Following stepwise covariate model building, SCr was retained as single marker of kidney function (after accounting for weight and PMA) in the final model. Compared to the final model based on SCr, the alternative model based on S-CysC showed very similar performance (e.g. BIC of 578.3 vs. 576.4) but included one additional covariate: impact of mechanical ventilation on vancomycin clearance, in addition to the effects of size and maturation.Conclusion: ill neonates. However, if using S-CysC for this purpose mechanical ventilation needs to be taken into account.

scholarly journals Serum Cystatin C as a Biomarker for Early Diabetic Nephropathy and Dyslipidemia in Young Type 1 Diabetes Patients

2020 ◽  
Author(s):  
Lina Radzeviciene ◽  
Ingrida Stankute ◽  
Ausra Monstaviciene ◽  
Rimantė Dobrovolskiene ◽  
Evalda Danyte ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Kidney Function ◽  
Cystatin C ◽  
Young Patients ◽  
Kidney Injury ◽  
Albumin Excretion Rate ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Long Term Follow Up

Abstract Background. Early capture of initial stages of complications is the destination of long term follow up of type 1 diabetes (T1D) patients. The aim of this study was to assess the clinical significance of serum cystatin C in the early diagnosis of renal injury and its association with dyslipidemia in young T1D patients.Methods. 779 subjects were evaluated for kidney function by estimating glomerular filtration rate (eGFR) based on serum creatinine (eGFRcreat) and cystatin C (eGFRcys). Results. Median age of study subjects was 16.2 years (2.1;26.4), diabetes duration – 5.3 years (0.51;24.0). The median of HbA1c was 8% (5.2;19.9) (64 mmol/mol (33.3;194)); 24.2% of participants had HbA1c <7% (53 mmol/mol). Elevated albumin excretion rate was found in 13.5% of subjects. The median of cystatin C was 0.8 mg/L (0.33;1.71), the median of creatinine – 63 µmol/L (6;126). Median of eGFRcys was lower than eGFRcreat (92 ml/min/1.73m2 vs. 101 ml/min/1.73m2, p<0.001). 30.2% of all patients were classified as having worse kidney function when using cystatin C vs. creatinine for eGFR calculation. Linear correlations were found between cystatin C and HbA1c, r=-0.088, p<0.05, as well as cystatin C and HDL, r=-0.097, p<0.01.Conclusion. This study showed that cystatin C might be used as an additional biomarker of early kidney injury for young patients with T1D.

scholarly journals Comparison of serum cystatin C and creatinine changes after cardiopulmonary bypass in patients with normal preoperative kidney function

2013 ◽  
Vol 45 (6) ◽  
pp. 1597-1603 ◽  
Author(s):  
Anders S. Svensson ◽  
Csaba P. Kovesdy ◽  
John-Peder Escobar Kvitting ◽  
Magnus Rosén ◽  
Ingemar Cederholm ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Kidney Function ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Is serum cystatin C a better marker of kidney function than serum creatinine in septic newborns?

2012 ◽  
Vol 66 ◽  
pp. 175-180 ◽  
Author(s):  
Iwona Maruniak-Chudek ◽  
Teresa Owsianka-Podleśny ◽  
Jolanta Wróblewska ◽  
Danuta Jadamus-Niebrój
Keyword(s):  
Serum Creatinine ◽  
Kidney Function ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin
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