scholarly journals Haematological and molecular responses in refractory anaemia with ring sideroblasts and thrombocytosis treated with lenalidomide

2013 ◽  
Vol 92 (2) ◽  
pp. 179-180 ◽  
Author(s):  
Jo Caers ◽  
Kaoutar Hafraoui ◽  
Aurore Keutgens ◽  
Jean-Hubert Caberg ◽  
Frederic Lambert ◽  
...  
Keyword(s):  
Refractory Anaemia ◽  
Molecular Responses ◽  
Ring Sideroblasts

Iron Overload, Oxidative Damage and Ineffective Erythropoiesis in Myelodysplastic Syndromes

2010 ◽  
Vol 00 (04) ◽  
pp. 34 ◽  
Author(s):  
Rosangela Invernizzi ◽  
Keyword(s):  
Oxidative Damage ◽  
Iron Overload ◽  
Myelodysplastic Syndromes ◽  
Iron Homeostasis ◽  
Current Knowledge ◽  
Early Stage ◽  
Refractory Anaemia ◽  
Ineffective Erythropoiesis ◽  
Ring Sideroblasts ◽  
High Level

A high level of apoptosis may be responsible for the ineffective haematopoiesis in myelodysplastic syndromes (MDS). Recently, it has been demonstrated that the erythroid apoptosis of low-risk MDS is initiated at a very early stage in stem cells and is associated with mitochondrial dysfunction. However, the underlying pathogenetic mechanisms causing malfunctioning of mitochondria and initiation of the intrinsic apoptotic cascade are not completely clear. Recent studies suggest a close relationship between impaired iron metabolism and pathogenesis of myelodysplasia. In fact, iron overload, which is apparent in refractory anaemia with and without ring sideroblasts, may lead to the generation of intracellular free radicals, thereby causing oxidative damage and inducing apoptosis in haematopoietic progenitors. This review summarises current knowledge supporting the role of iron-related oxidative damage in the pathogenesis of MDS. The relationship between mitochondrial iron homeostasis impairment and ineffective erythropoiesis in refractory anaemia with ring sideroblasts as well as the various functions of the cytosolic and mitochondrial ferritins are also discussed.

scholarly journals Low rate of calreticulin mutations in refractory anaemia with ring sideroblasts and marked thrombocytosis

Leukemia ◽  
2014 ◽  
Vol 28 (6) ◽  
pp. 1374-1376 ◽  
Author(s):  
J Broséus ◽  
E Lippert ◽  
A S Harutyunyan ◽  
S Jeromin ◽  
E Zipperer ◽  
...  
Keyword(s):  
Refractory Anaemia ◽  
Ring Sideroblasts ◽  
Low Rate

Refractory anaemia with ring sideroblasts (RAS): Caracterization and prognostic factors

1991 ◽  
Vol 15 ◽  
pp. 18
Author(s):  
T. Vallespí ◽  
F. López ◽  
D. Irriguible ◽  
G. Sanz ◽  
A. Juliá ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Refractory Anaemia ◽  
Ring Sideroblasts

SIGNIFICANCE OF RING SIDEROBLASTS IN REFRACTORY ANAEMIA WITH EXCESS OF BLASTS

1987 ◽  
Vol 65 (1) ◽  
pp. 119-120 ◽  
Author(s):  
Yataro Yoshida ◽  
Shigeru Oguma ◽  
Haruto Uchino ◽  
Tadashi Maekawa
Keyword(s):  
Refractory Anaemia ◽  
Ring Sideroblasts

Refractory anaemia with ring sideroblasts (RAS): A simple scoring system based on easily available parameters

1991 ◽  
Vol 15 ◽  
pp. 18 ◽  
Author(s):  
T. Vallespí ◽  
F. López ◽  
G. Sanz ◽  
D. Irriguible ◽  
A. Jullá ◽  
...  
Keyword(s):  
Scoring System ◽  
Refractory Anaemia ◽  
Ring Sideroblasts

scholarly journals Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF

2009 ◽  
Vol 149 (6) ◽  
pp. 844-854 ◽  
Author(s):  
Maryam Nikpour ◽  
Andrea Pellagatti ◽  
Anquan Liu ◽  
Mohsen Karimi ◽  
Luca Malcovati ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Refractory Anaemia ◽  
Ring Sideroblasts

scholarly journals Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF 3B1 mutated refractory anaemia with ring sideroblasts

2015 ◽  
Vol 171 (4) ◽  
pp. 478-490 ◽  
Author(s):  
Simona Conte ◽  
Shintaro Katayama ◽  
Liselotte Vesterlund ◽  
Mohsen Karimi ◽  
Marios Dimitriou ◽  
...  
Keyword(s):  
Refractory Anaemia ◽  
Aberrant Splicing ◽  
Ring Sideroblasts ◽  
Erythroid Maturation ◽  
Haemoglobin Synthesis

scholarly journals Schizophrenia and refractory anaemia with ring sideroblasts

2004 ◽  
Vol 125 (5) ◽  
pp. 543-543 ◽  
Author(s):  
Alicia Domingo-Claros ◽  
Esther Alonso ◽  
Esmeralda de la Banda
Keyword(s):  
Refractory Anaemia ◽  
Ring Sideroblasts

scholarly journals Age, JAK2V617F and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis

Leukemia ◽  
2013 ◽  
Vol 27 (9) ◽  
pp. 1826-1831 ◽  
Author(s):  
J Broséus ◽  
◽  
T Alpermann ◽  
M Wulfert ◽  
L Florensa Brichs ◽  
...  
Keyword(s):  
Refractory Anaemia ◽  
Predicting Factors ◽  
Ring Sideroblasts
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