Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein-Barr virus, and clonality are important predictors of disease progression and regression

2013 ◽  
Vol 91 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Ayako Ichikawa ◽  
Fumiko Arakawa ◽  
Junichi Kiyasu ◽  
Kensaku Sato ◽  
Hiroaki Miyoshi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Progression ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disorders ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Nobuo Takemori ◽  
Hiroyuki Kaneko ◽  
Masaya Nakamura ◽  
Masaru Kojima
Keyword(s):  
Rheumatoid Arthritis ◽  
Complete Remission ◽  
Hodgkin’S Lymphoma ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disorders ◽  
Hodgkin's Lymphoma ◽  
Course Of Illness ◽  
Barr Virus ◽  
Epstein Barr

Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin’s lymphoma (HL), in which a dramatic complete remission was achieved after withdrawal of MTX coupled with clarithromycin (CAM) administration. Withdrawal of MTX coupled with CAM administration seemed to be effective for treating MTX-related EBV-associated LPDs. In particular, an immunomodulative effect of CAM might have been involved in achieving complete remission.

scholarly journals mTOR inhibitor monotherapy is insufficient to suppress viremia and disease progression in Epstein-Barr virus-driven lymphoproliferative disorders (EBV-LPD)

2008 ◽  
Vol 83 (8) ◽  
pp. 688-689 ◽  
Author(s):  
Shernan G. Holtan ◽  
Luis F. Porrata ◽  
Joseph P. Colgan ◽  
Clive S. Zent ◽  
Thomas M. Habermann ◽  
...  
Keyword(s):  
Disease Progression ◽  
Epstein Barr Virus ◽  
Mtor Inhibitor ◽  
Lymphoproliferative Disorders ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies

2009 ◽  
Vol 11 (3) ◽  
pp. R77 ◽  
Author(s):  
Corinne Miceli-Richard ◽  
Nicolas Gestermann ◽  
Corinne Amiel ◽  
Jérémie Sellam ◽  
Marc Ittah ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Viral Load ◽  
T Cell ◽  
Cell Response ◽  
Epstein Barr Virus ◽  
T Cell Response ◽  
Barr Virus ◽  
Epstein Barr

Remission of lymphoma after withdrawal of methotrexate in rheumatoid arthritis: Relationship with type of latent Epstein-Barr virus infection

2007 ◽  
Vol 82 (12) ◽  
pp. 1106-1109 ◽  
Author(s):  
Takuya Miyazaki ◽  
Katsumichi Fujimaki ◽  
Yukari Shirasugi ◽  
Fumiaki Yoshiba ◽  
Manabu Ohsaka ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection
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