scholarly journals Duration of untreated illness of patients with obsessive–compulsive disorder in Japan

2020 ◽  
Author(s):  
Yoshihiro Matsumoto ◽  
Takashi Nakamae ◽  
Yoshinari Abe ◽  
Anri Watanabe ◽  
Jin Narumoto
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Duration Of Untreated Illness

Duration of untreated illness and outcome of obsessive-compulsive disorder: A naturalistic follow-up study

2017 ◽  
Vol 41 (S1) ◽  
pp. S323-S323
Author(s):  
V. Prisco ◽  
F. Perris ◽  
T. Iannaccone ◽  
M. Fabrazzo ◽  
F. Catapano
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Rating Scale ◽  
Clinical Interview ◽  
Obsessive Compulsive ◽  
Long Term Outcome ◽  
Compulsive Disorder ◽  
Duration Of Untreated Illness ◽  
Poor Outcome ◽  
Axis I ◽  
Dsm Iv

Duration of untreated illness (DUI) is a predictor of outcome in psychotic and affective disorders. Data available on DUI and its relationship with outcome in obsessive-compulsive disorder (OCD) suggest an association between longer DUI and poorer treatment response. The present study investigated socio-demographic and clinical predictors of DUI and its association with long-term outcome in OCD patients. Eighty-three OCD outpatients were treated with serotonin reuptake inhibitors (SRIs) and prospectively followed-up for 3 years. Baseline information was collected on demographic and clinical characteristics using standard assessments. Each patient was assessed through the structured clinical interview for DSM-IV axis I disorders (SCID-I), the structured clinical interview for DSM-IV axis II personality disorders (SCID-II), the Yale-Brown obsessive–compulsive scale (Y-BOCS) and the 17-item Hamilton rating scale for depression (HDRS). The DUI was explored by interviewing patients, family caregivers and clinicians. OCD subjects had a mean DUI of 7.3 (5.8) years. A younger age at onset and a greater severity of OCD symptoms at baseline were associated with a longer DUI. The DUI of patients with a “good outcome” was shorter than that of patients with a “poor outcome”. Logistic regression analysis revealed indeed a possible association between longer DUI and “poor outcome”. In the logistic multivariable model, the association of DUI with treatment outcome held true whilst controlling for socio-demographic and clinical variables.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Differences in duration of untreated illness, duration, and severity of illness among clinical phenotypes of obsessive-compulsive disorder

CNS Spectrums ◽  
2014 ◽  
Vol 20 (5) ◽  
pp. 474-478 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Beatrice Benatti ◽  
Lucio Oldani ◽  
Gregorio Spagnolin ◽  
A.Carlo Altamura
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Severity Of Illness ◽  
Comorbid Condition ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Clinical Phenotypes ◽  
Duration Of Untreated Illness ◽  
Multiple Phenotypes ◽  
Duration Of Illness ◽  
The Mean

IntroductionObsessive-compulsive disorder (OCD) is a prevalent, disabling, and comorbid condition that is frequently under-recognized and poorly treated. OCD phenotypes may differ in terms of clinical presentation and severity. However, few studies have investigated whether clinical phenotypes differ in terms of latency to treatment (ie, duration of untreated illness[DUI]), duration, and severity of illness. The present study was aimed to quantify the aforementioned variables in a sample of OCD patients.MethodsOne hundred fourteen outpatients with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnosis of OCD were recruited, and their main clinical features were collected. Severity of illness was assessed through the Yale–Brown Obsessive Compulsive Scale (Y-BOCS), and the main phenotypes were identified through the Y-BOCS Symptom Checklist. A one-way analysis of variance (ANOVA) test, followed by a Bonferroni post-hoc test, were performed to compare DUI, duration, and severity of illness across subgroups.ResultsIn the whole sample, the mean DUI exceeded 7 years (87.35±11.75 months), accounting for approximately half of the mean duration of illness (172.2±13.36 months). When subjects were categorized into 4 main clinical phenotypes, respectively, aggressive/checking (n=31), contamination/cleaning (n=37), symmetry/ordering (n=32), and multiple phenotypes (n=14), DUI, duration, and severity of illness resulted significantly higher in the aggressive/checking subgroup, compared to other subgroups (F=3.58, p<0.01; F=3.07, p<0.01; F=4.390, p<0.01).DiscussionIn a sample of OCD patients, along with a mean latency to treatment of approximately 7 years, regardless of the phenotype, patients had spent half of their duration of illness (DI) without being treated. DUI, duration, and severity of illness resulted significantly higher in the aggressive/checking subgroup.

Factors associated with the duration of untreated illness among patients with obsessive compulsive disorder

2015 ◽  
Vol 58 ◽  
pp. 88-93 ◽  
Author(s):  
Cana Aksoy Poyraz ◽  
Şenol Turan ◽  
Nazife Gamze Usta Sağlam ◽  
Gizem Çetiner Batun ◽  
Ahmet Yassa ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Factors Associated ◽  
Duration Of Untreated Illness

scholarly journals Duration of untreated illness and response to SRI treatment in Obsessive-Compulsive Disorder

2019 ◽  
Vol 58 ◽  
pp. 19-26 ◽  
Author(s):  
Umberto Albert ◽  
Francesca Barbaro ◽  
Stefano Bramante ◽  
Gianluca Rosso ◽  
Diana De Ronchi ◽  
...  
Keyword(s):  
Mental Health ◽  
Obsessive Compulsive Disorder ◽  
Mental Health Professionals ◽  
Primary Care Physicians ◽  
Age At Onset ◽  
Response Rates ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Duration Of Untreated Illness ◽  
The Mean

AbstractBackground:The duration of untreated illness (DUI) is a potentially modifiable parameter associated with worst prognosis in several psychiatric disorders, but poorly investigated in Obsessive-Compulsive Disorder (OCD). Our aims were to estimate the mean DUI in a large sample of individuals with OCD and its impact on response to the first ever adequate SRI treatment.Methods:We retrospectively examined records of 251 patients with OCD (SCID-I, DSM-IV) who referred to our Department and were prospectively and naturalistically treated according to International Guidelines. The DUI was defined as the interval between age at onset and age at which patients received their first adequate pharmacological treatment. Response rates were compared in subjects with brief (≤24 months) versus long DUI. Logistic regression models predicting response and 12-week Y-BOCS score were run with DUI (among others) as independent variable.Results:The mean DUI was 106.19 ± 118.14 months, with a mean interval between onset of the disorder and when patients sought professional help of 82.27 ± 112.30 months. Response rates were significantly reduced in subjects with a long DUI, using both the cut-off of 24 months and the median value of 60 months. Regression analyses confirmed that a long (>24 months) DUI predicts poorer response and higher Y-BOCS scores at 12 weeks.Conclusions:Our results, although preliminary, seem to suggest that a longer duration of untreated illness in OCD is associated with poorer outcome in terms of response to SRI treatments. It is imperative to do all the possible to shorten the DUI, both by improving access to mental health services, improving the ability of primary care physicians and mental health professionals to recognize OCD, and disseminate best-practice prescription guidelines.

Duration of untreated illness predicts 3-year outcome in patients with obsessive-compulsive disorder: A real-world, naturalistic, follow-up study

2021 ◽  
Vol 299 ◽  
pp. 113872
Author(s):  
Francesco Perris ◽  
Gaia Sampogna ◽  
Vincenzo Giallonardo ◽  
Salvatore Agnese ◽  
Carmela Palummo ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Real World ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Duration Of Untreated Illness ◽  
Follow Up Study
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