scholarly journals Substance use in clinical high risk for psychosis: a review of the literature

2013 ◽  
Vol 8 (2) ◽  
pp. 104-112 ◽  
Author(s):  
Jean Addington ◽  
Nevicia Case ◽  
Majid M. Saleem ◽  
Andrea M. Auther ◽  
Barbara A. Cornblatt ◽  
...  
Keyword(s):  
Substance Use ◽  
High Risk ◽  
Clinical High Risk ◽  
Review Of The Literature

scholarly journals Substance use in individuals at clinical high risk of psychosis

2015 ◽  
Vol 45 (11) ◽  
pp. 2275-2284 ◽  
Author(s):  
L. Buchy ◽  
K. S. Cadenhead ◽  
T. D. Cannon ◽  
B. A. Cornblatt ◽  
T. H. McGlashan ◽  
...  
Keyword(s):  
Substance Use ◽  
High Risk ◽  
Clinical Outcome ◽  
Tobacco Use ◽  
Cannabis Use ◽  
Longitudinal Impact ◽  
Clinical High Risk ◽  
Alcohol And Drug Use ◽  
Additional Information ◽  
Lower Alcohol

BackgroundA series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of developing psychosis than in controls. Little is known about the longitudinal trajectory of substance use, and findings on the relationship between substance use and later transition to psychosis in CHR individuals are mixed.MethodAt baseline and 6- and 12-month follow-ups, 735 CHR and 278 control participants completed the Alcohol and Drug Use Scale and a cannabis use questionnaire. The longitudinal trajectory of substance use was evaluated with linear mixed models.ResultsCHR participants endorsed significantly higher cannabis and tobacco use severity, and lower alcohol use severity, at baseline and over a 1-year period compared with controls. CHR youth had higher lifetime prevalence and frequency of cannabis, and were significantly younger upon first use, and were more likely to use alone and during the day. Baseline substance use did not differentiate participants who later transitioned to psychosis (n = 90) from those who did not transition (n = 272). Controls had lower tobacco use than CHR participants with a prodromal progression clinical outcome and lower cannabis use than those with a psychotic clinical outcome at the 2-year assessment.ConclusionsIn CHR individuals cannabis and tobacco use is higher than in controls and this pattern persists across 1 year. Evaluation of clinical outcome may provide additional information on the longitudinal impact of substance use that cannot be detected through evaluation of transition/non-transition to psychosis alone.

scholarly journals Substance use in people at clinical high-risk for psychosis

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Debra A Russo ◽  
Jan Stochl ◽  
Michelle Painter ◽  
Peter B Jones ◽  
Jesus Perez
Keyword(s):  
Substance Use ◽  
High Risk ◽  
Clinical High Risk

scholarly journals Impact of substance use on conversion to psychosis in youth at clinical high risk of psychosis

2014 ◽  
Vol 156 (2-3) ◽  
pp. 277-280 ◽  
Author(s):  
Lisa Buchy ◽  
Diana Perkins ◽  
Scott W. Woods ◽  
Lu Liu ◽  
Jean Addington
Keyword(s):  
Substance Use ◽  
High Risk ◽  
Clinical High Risk
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