Host‐associated differentiation of target pests should be assessed before using gene drive as a pest control tool – an opinion

Author(s):  
Raul F. Medina
2017 ◽  
Author(s):  
Austin Burt ◽  
Anne Deredec

AbstractIn male heterogametic species the Y chromosome is transmitted solely from fathers to sons, and is selected for based only on its impacts on male fitness. This fact can be exploited to develop efficient pest control strategies that use Y-linked editors to disrupt the fitness of female descendants. In simple “strategic” population models we show that Y-linked editors can be substantially more efficient than other self-limiting strategies and, while not as efficient as gene drive approaches, are expected to have less impact on non-target populations with which there is some gene flow. Efficiency can be further augmented by simultaneously releasing an autosomal X-shredder construct, in either the same or different males. Y-linked editors may be attractive option to consider when efficient control of a species is desired in some locales but not others.


2020 ◽  
Author(s):  
Edith A. MacDonald ◽  
Eric Edwards ◽  
Jovana Balanovic ◽  
Fabien Medvecky

1996 ◽  
Vol 2 (1) ◽  
pp. 171-177 ◽  
Author(s):  
John P. Parkes ◽  
Graham Nugent ◽  
Bruce Warburton

2020 ◽  
Vol 14 (7) ◽  
pp. 904-918 ◽  
Author(s):  
Edith A. MacDonald ◽  
Jovana Balanovic ◽  
Eric D. Edwards ◽  
Wokje Abrahamse ◽  
Bob Frame ◽  
...  

2017 ◽  
Vol 5 (sup1) ◽  
pp. S98-S120 ◽  
Author(s):  
Maxwell J. Scott ◽  
Fred Gould ◽  
Marcé Lorenzen ◽  
Nathaniel Grubbs ◽  
Owain Edwards ◽  
...  

2021 ◽  
Author(s):  
Mathieu Legros ◽  
John M. Marshall ◽  
Sarina Macfadyen ◽  
Keith R. Hayes ◽  
Andy Sheppard ◽  
...  

2018 ◽  
Vol 285 (1883) ◽  
pp. 20180776 ◽  
Author(s):  
Austin Burt ◽  
Anne Deredec

In male heterogametic species the Y chromosome is transmitted solely from fathers to sons, and is selected for based only on its impacts on male fitness. This fact can be exploited to develop efficient pest control strategies that use Y-linked editors to disrupt the fitness of female descendants. With simple population genetic and dynamic models we show that Y-linked editors can be substantially more efficient than other self-limiting strategies and, while not as efficient as gene drive approaches, are expected to have less impact on non-target populations with which there is some gene flow. Efficiency can be further augmented by simultaneously releasing an autosomal X-shredder construct, in either the same or different males. Y-linked editors may be an attractive option to consider when efficient control of a species is desired in some locales but not others.


EMBO Reports ◽  
2017 ◽  
Vol 18 (9) ◽  
pp. 1481-1481 ◽  
Author(s):  
Virginie Courtier‐Orgogozo ◽  
Baptiste Morizot ◽  
Christophe Boëte
Keyword(s):  

EMBO Reports ◽  
2017 ◽  
Vol 18 (6) ◽  
pp. 878-880 ◽  
Author(s):  
Virginie Courtier‐Orgogozo ◽  
Baptiste Morizot ◽  
Christophe Boëte

Sign in / Sign up

Export Citation Format

Share Document