Biological effects of secondary metabolites of Inula racemosa on the parasitoid Bracon hebetor

2021 ◽  
Author(s):  
Mandeep Kaur ◽  
Isha Saraf ◽  
Rakesh Kumar ◽  
Inder Pal Singh ◽  
Sanehdeep Kaur
Keyword(s):  
Secondary Metabolites ◽  
Biological Effects ◽  
Inula Racemosa ◽  
Bracon Hebetor

scholarly journals Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 957
Author(s):  
Mamona Nazir ◽  
Muhammad Saleem ◽  
Muhammad Imran Tousif ◽  
Muhammad Aijaz Anwar ◽  
Frank Surup ◽  
...  
Keyword(s):  
Amino Acids ◽  
Secondary Metabolites ◽  
Biological Effects ◽  
Structural Diversity ◽  
Chemical Diversity ◽  
Biosynthetic Pathways ◽  
Natural Sources ◽  
Hybrid Compounds ◽  
Anti Inflammatory

Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

scholarly journals Short Communication: Identification and evaluation of bioactivity in forest plants used for medicinal purposes by the Kutai community of East Kalimantan, Indonesia

2018 ◽  
Vol 19 (1) ◽  
pp. 253-259 ◽  
Author(s):  
ABDUL RASYID ZARTA ◽  
WIWIN SUWINARTI ◽  
FARIDA ARIYANI ◽  
IRAWAN WIJAYA KUSUMA ◽  
ENOS TANGKE ARUNG
Keyword(s):  
Antioxidant Activity ◽  
Secondary Metabolites ◽  
Plant Species ◽  
Short Communication ◽  
Biological Effects ◽  
Bacterial Activity ◽  
Plant Materials ◽  
Vitro Assay ◽  
East Kalimantan ◽  
Forest Plants

Zarta AR, Ariyani F, Suwinarti W, Kusuma IW, Arung ET. 2018. Short Communication: Identification and evaluation of bioactivity in forest plants used for medicinal purposes by the Kutai community of East Kalimantan, Indonesia. Biodiversitas 19: 253- 259. The Indonesian forest is one of the most species-rich ecosystems in the world. Within such forests are plant species with secondary metabolites that have novel molecular structure and diverse biological activity with excellent potential to be used medicinally in prevention and cure of various diseases afflicting humans. Plant materials often contain various forms of antioxidants. Phenolic compounds found in plants have many biological effects. Flavonoids and other phenolics play a protective role against metabolic damage caused by disease and environmental stressors. The communities of Kutai Kartanegara in East Kalimantan Indonesia are representative of many traditional peoples who have evolved ways of treating human ailment and disease by use of specific plants sourced from their forests. The purpose of the research described in this paper was to identify significant medicinal plant species used by the Kutai ethnic community and to prepare extracts from these plants, mainly from the leaves, and to evaluate the extracts for bioactivity; namely by general identification of secondary metabolites, and by estimation of their antioxidant activity, toxicity, and antibacterial activity. Samples of ten plant species, used medicinally by the Kutai community, were extracted using ethanol solvent. Assay of antioxidant activity was carried out by the spectrophotometric method using DPPH (1,1-diphenyl-2-picrylhydrazyl radical) as the control. The degree of toxicity of the extracts was determined by the BSLT (Brine Shrimp Lethality Test) while anti-bacterial activity was evaluated using an in vitro assay of growth inhibition of cultures of the bacterium Escherichia coli. The result showed that nine of the plant species had strong antioxidant activity (IC50); extracts of two of the species were very toxic, while one other was toxic; and at least eight of the species had extracts that exhibited anti-bacterial activity. The phytochemical compounds identified in several of the ten species included flavonoids, tannins, saponins, steroids, triterpenoids, and alkaloids.

Modulation of Long Non-Coding RNAs by Different Classes of Secondary Metabolites from Plants: A Mini-Review on Antitumor Effects

2021 ◽  
Vol 21 ◽  
Author(s):  
Tamires Cunha Almeida ◽  
Janaína Brandão Seibert ◽  
Tatiane Roquete Amparo ◽  
Gustavo Henrique Bianco de Souza ◽  
Glenda Nicioli da Silva ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Large Scale ◽  
Biological Effects ◽  
Migration And Invasion ◽  
Antitumor Action ◽  
Pharmacokinetic Parameters ◽  
Antitumor Effects ◽  
Antitumor Potential ◽  
Inhibition Of Tumor Growth ◽  
Non Coding Rnas

: The broad pharmacological spectrum of plants is related to their secondary metabolism, which is responsible for the synthesis of different compounds that have multiple effects on cellular physiology. Among the biological effects presented by phytochemicals, their use for the prevention and treatment of cancer can be highlighted. This occurs due to several mechanisms of antitumor action demonstrated by these compounds, including regulation of the cell signaling pathways and inhibition of tumor growth. In this way, long non-coding RNAs (lncRNAs) appear to be promising targets for the treatment of cancer. Their deregulation has already been related to a variety of clinical-pathological parameters. However, the effects of secondary metabolites on lncRNAs are still restricted. For this reason, the present review aimed to gather data on phytochemicals with action on lncRNAs in order to confirm their possible antitumor potential. According to the literature, terpenoid and flavonoid are the main examples of secondary metabolites involved with lncRNAs activity. In addition, the lncRNAs H19, CASC2, HOTAIR, NKILA, CCAT1, MALAT1, AFAP1-AS1, MEG3, and CDKN2B-AS1 can be highlighted as important targets in the search for new anti-tumor agents since they act as modulating pathways related to cell proliferation, cell cycle, apoptosis, cell migration and invasion. Finally, challenges for the use of natural products as a commercial drug were also discussed. The low yield, selectivity index and undesirable pharmacokinetic parameters were emphasized as a difficulty for obtaining these compounds on a large scale and for improving the potency of its biological effect. However, the synthesis and/or development of formulations were suggested as a possible approach to solve these problems. All of these data together confirm the potential of secondary metabolites as a source of new anti-tumor agents acting on lncRNAs.

scholarly journals Fate in Soil of Flavonoids Released from White Clover (Trifolium repensL.)

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Sandra C. K. Carlsen ◽  
Hans A. Pedersen ◽  
Niels H. Spliid ◽  
Inge S. Fomsgaard
Keyword(s):  
Secondary Metabolites ◽  
White Clover ◽  
Cover Crop ◽  
Biological Effects ◽  
Limited Attention ◽  
Cattle Feed ◽  
Flavonoid Aglycones ◽  
Bioactive Secondary Metabolites ◽  
High Concentrations ◽  
First Time

White clover is frequently used as a leguminous cover crop, serving as green manure, and is also included with grasses in cattle feed mixtures. Numerous biological effects reported for clover cultivation have been attributed to the production of bioactive secondary metabolites. Thus far the presence in soil of bioactive secondary metabolites from clover has received limited attention. In this paper we examine for the first time the release of flavonoids both from field-grown white clover and from soil-incorporated white clover plants of flavonoids, as analyzed by LC-MS/MS. The dominant flavonoid aglycones were formononetin, medicarpin, and kaempferol. Soil-incorporated white clover plants generated high concentrations of the glycosides kaempferol-Rha-Xyl-Gal and quercetin-Xyl-Gal. Substantial amounts of kaempferol persisted in the soil for days while the other compounds were degraded faster. These compounds should be considered in future studies of soil fatigue, allelopathic activity, and possible environmental risks from extended clover cultivation.

scholarly journals Research on the Scientific Evolution of the Flavonoid Agathisflavone

2018 ◽  
Vol 21 ◽  
pp. 376-385 ◽  
Author(s):  
Vanessa Cristina Meira De Amorim ◽  
Markley Silva Oliveira Júnior ◽  
Eduardo Muniz Santana Bastos ◽  
Victor Diogenes Amaral Da Silva ◽  
Silvia Lima Costa
Keyword(s):  
Experimental Design ◽  
Secondary Metabolites ◽  
Plant Species ◽  
Biological Activities ◽  
Biological Effects ◽  
Therapeutic Effects ◽  
Research Development ◽  
Prospective Research ◽  
Microsoft Office

Purpose: Flavonoids are a group of secondary metabolites of the polyphenols class present in several plant species. Among them, the biflavonoid agathisflavone is of interest since it bears several biological effects that include: antiviral, antitumoral, antiprotozoal and neurogenic actions. In this sense, this study aims to use the important tool of scientific prospecting to assess the level of research development concerning the flavonoid agathisflavone. Methods: The experimental design was carried out through strategic reach with keywords on the PubMed (National Center for Biotechnology Information - NCBI) and Science Direct platforms. The articles were compiled and exported to Microsoft Office Excel 2007, where they were analyzed, stored and distributed in charts organized as to different countries, year of publication of scientific articles and journals RESULTS: The prospective research resulted in the identification of 81 scientific productions, published in several journals, submitted by different countries, in several areas of medical domain and in different years of publication over the last 50 years (1965 - 2018). It was also possible to investigate the advances in the study of agathisflavone for the development of new therapeutics. Conclusion: Although agathisflavone has been known in the literature since at least 1969, only 23 of the eligible articles found evaluated its possible therapeutic effects. The demonstrated biological activities of agathisflavone range from antiprotozoal to neurogenesis and neuroprotection, however, the molecule needs to be better studied at the in vivo and human level.

scholarly journals Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5153
Author(s):  
Naureen Banu ◽  
Najmul Alam ◽  
Mohammad Nazmul Islam ◽  
Sanjida Islam ◽  
Shahenur Alam Sakib ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Methanol Extract ◽  
Biological Activities ◽  
Biological Effects ◽  
Experimental Models ◽  
Clot Lysis ◽  
Control Group ◽  
Anti Inflammatory

Pani heloch (Antidesma montanum) is traditionally used to treat innumerable diseases and is a source of wild vegetables for the management of different pathological conditions. The present study explored the qualitative phytochemicals; quantitative phenol and flavonoid contents; in vitro antioxidant, anti-inflammatory, and thrombolytic effects; and in vivo antipyretic and analgesic properties of the methanol extract of A. montanum leaves in different experimental models. The extract exhibited secondary metabolites including alkaloids, flavonoids, flavanols, phytosterols, cholesterols, phenols, terpenoids, glycosides, fixed oils, emodines, coumarins, resins, and tannins. Besides, Pani heloch showed strong antioxidant activity (IC50 = 99.00 µg/mL), while a moderate percentage of clot lysis (31.56%) in human blood and significant anti-inflammatory activity (p < 0.001) was achieved with the standard. Moreover, the analgesic and antipyretic properties appeared to trigger a significant response (p < 0.001) relative to in the control group. Besides, an in silico study of carpusin revealed favorable protein-binding affinities. Furthermore, the absorption, distribution, metabolism, excretion, and toxicity analysis and toxicological properties of all isolated compounds adopted Lipinski’s rule of five for drug-like potential and level of toxicity. Our research unveiled that the methanol extract of A. montanum leaves exhibited secondary metabolites that are a good source for managing inflammation, pyrexia, pain, and cellular toxicity. Computational approaches and further studies are required to identify the possible mechanism which responsible for the biological effects.

scholarly journals Neuroprotective Potential of Secondary Metabolites from Melicope lunu-ankenda (Rutaceae)

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3109 ◽  
Author(s):  
Zeinab Abdulwanis Mohamed ◽  
Enas Mohamed Eliaser ◽  
Emanuela Mazzon ◽  
Patrick Rollin ◽  
Gwendoline Cheng Lian Ee ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Neurodegenerative Diseases ◽  
Protective Effect ◽  
Biological Activities ◽  
Biological Effects ◽  
Neuroprotective Activity ◽  
Alternative Medicines ◽  
Health Disorders ◽  
Phenolic Acid Derivatives ◽  
Different Parts

Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. Melicope lunu-ankenda is one Melicope species (family Rutaceae), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert different biological activities such as antioxidant and anti-inflammatory qualities, resulting in a protective effect against several health disorders including neurodegenerative diseases. Various secondary metabolites such as phenolic acid derivatives, flavonoids, coumarins and alkaloids, isolated from the M. lunu-ankenda plant, were demonstrated to have neuroprotective activities and also exert many other beneficial biological effects. A number of studies have revealed different neuroprotective mechanisms for these secondary metabolites. This review summarizes the most significant and recent studies for neuroprotective activity of M. lunu-ankenda major secondary metabolites in neurodegenerative diseases.

scholarly journals Biological Potential and Medical Use of Secondary Metabolites

Medicines ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 66 ◽  
Author(s):  
Ana M. L. Seca ◽  
Diana C. G. A. Pinto
Keyword(s):  
Secondary Metabolites ◽  
Biological Effects ◽  
Experimental Results ◽  
Special Issue ◽  
Therapeutic Applications ◽  
Lead Compounds ◽  
Biological Potential ◽  
The World ◽  
Bioactive Secondary Metabolites ◽  
New Methodologies

This Medicines special issue focuses on the great potential of secondary metabolites for therapeutic applications. The special issue contains 16 articles reporting relevant experimental results and overviews of bioactive secondary metabolites. Their biological effects and new methodologies that improve the lead compounds’ synthesis were also discussed. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this special issue.

scholarly journals The Chemical Featuring, Toxicity, and Antimicrobial Activity of Psidium cattleianum (Myrtaceae) Leaves

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
José Henrique Faleiro ◽  
Randys Caldeira Gonçalves ◽  
Mara Núbia Guimarães dos Santos ◽  
Diego Pereira da Silva ◽  
Plínio Lázaro Faleiro Naves ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Burkholderia Cepacia ◽  
Biological Effects ◽  
Ethanol Extract ◽  
New Drugs ◽  
Diffusion Method ◽  
Psidium Cattleianum ◽  
Low Toxicity

It is known that the phytochemical identification and assessment of biological effects caused by the constituent species Psidium cattleianum, which belongs to family Myrtaceae, are poorly held in the literature. The aim of the current study is to investigate the composition of secondary metabolites, the toxicity, and the antimicrobial activity of P. cattleianum leaves. The crude ethanolic extract of the plant was obtained through maceration and fractionated with hexane, dichloromethane, and ethyl acetate. The crude ethanol extract and the fractions were subjected to phytochemical screening and tested against the microcrustacean Artemia salina for toxicological assessment. Antimicrobial tests with crude ethanol extract and the fractions were carried out through the agar diffusion method using broth microdilution against Staphylococcus aureus, S. epidermidis, Burkholderia cepacia, and Escherichia coli strains. A variety of secondary metabolite groups such as catechins, steroids, phenolic compounds, flavonoids, and saponins was detected. Regarding toxicity, hexane and dichloromethane fractions were considered nontoxic, whereas the crude ethanol extract and the ethyl acetate fraction showed low toxicity. The crude ethanol extract and the fractions, except for the hexane fraction, showed activity against the tested strains. Therefore, the composition of the secondary metabolites, the low toxicity, and the antimicrobial activity suggest that this species is promising in the search and development of new drugs.

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