Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

2021 ◽  
Author(s):  
Wen Guo ◽  
Xiaona Li ◽  
Juan Wu ◽  
Wenfang Zhu ◽  
Jing Lu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Alkaline Phosphatase ◽  
Arterial Stiffness ◽  
Chinese Population ◽  
Disease Risk ◽  
Serum Alkaline Phosphatase ◽  
Cardiovascular Disease Risk

scholarly journals Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

2021 ◽  
Author(s):  
Wen Guo ◽  
Xiaona Li ◽  
Juan Wu ◽  
Wenfang Zhu ◽  
Jing Lu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Alkaline Phosphatase ◽  
Arterial Stiffness ◽  
Roc Curve ◽  
Chinese Population ◽  
Disease Risk ◽  
Serum Alkaline Phosphatase ◽  
Subclinical Atherosclerosis ◽  
Cardiovascular Disease Risk ◽  
Cvd Risk

Abstract Background Serum alkaline phosphatase (ALP) has been recognized as a biomarker of cardiovascular disease (CVD) risk or mortality, recently. This study aimed to explore the association of ALP with arterial stiffness and 10-year CVD risk. Methods A total of 12539 participants without CVD who underwent health examinations including serum ALP level were retrospectively analyzed. Arterial stiffness was measured by brachial ankle pulse wave velocity (baPWV) and10-year CVD risk was evaluated by Framingham risk score (FRS). Results All participants were stratified into four groups according to the quartile of serum ALP. Participants with high ALP quartiles had higher cardiovascular parameters and baPWV, as well as an increase 10-year CVD risk. Logistic regression analysis showed that serum ALP was an independently risk factor for elevated baPWV and 10-year CVD risk after adjustment for traditional CVD risk factors in both women and men. In receiver operating characteristic (ROC) curve analysis, the area under the ROC curve (AUROC) of serum ALP for predicting elevated baPWV was 0.740 (95%CI 0.726–0.754, P < 0.001) in women, larger than that in men. Conclusions Serum ALP is independently associated with arterial stiffness and 10-year CVD risk in the general Chinese population. Our results also imply the better performance of serum ALP in women than men for predicting subclinical atherosclerosis.

scholarly journals Plasma Inorganic Pyrophosphate Deficiency Links Multiparity to Cardiovascular Disease Risk

2020 ◽  
Vol 8 ◽  
Author(s):  
Almudena Veiga-Lopez ◽  
Visalakshi Sethuraman ◽  
Nastassia Navasiolava ◽  
Barbara Makela ◽  
Isoken Olomu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Vascular Calcification ◽  
Alkaline Phosphatase Activity ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Inorganic Pyrophosphate ◽  
Ectopic Mineralization ◽  
In Pregnancy

Epidemiological studies indicate that elevated alkaline phosphatase activity is associated with increased cardiovascular disease risk. Other epidemiological data demonstrate that mothers giving multiple childbirths (multipara) are also at increased risk of developing late-onset cardiovascular disease. We hypothesized that these two associations stem from a common cause, the insufficient plasma level of the ectopic mineralization inhibitor inorganic pyrophosphate, which is a substrate of alkaline phosphatase. As alkaline phosphatase activity is elevated in pregnancy, we hypothesized that pyrophosphate concentrations decrease gestationally, potentially leading to increased maternal vascular calcification and cardiovascular disease risk in multipara. We investigated plasma pyrophosphate kinetics pre- and postpartum in sheep and at term in humans and demonstrated its shortage in pregnancy, mirroring alkaline phosphatase activity. Next, we tested whether multiparity is associated with increased vascular calcification in pseudoxanthoma elasticum patients, characterized by low intrinsic plasma pyrophosphate levels. We demonstrated that these patients had increased vascular calcification when they give birth multiple times. We propose that transient shortages of pyrophosphate during repeated pregnancies might contribute to vascular calcification and multiparity-associated cardiovascular disease risk threatening hundreds of millions of healthy women worldwide. Future trials are needed to assess if gestational pyrophosphate supplementation might be a suitable prophylactic treatment to mitigate maternal cardiovascular disease risk in multiparous women.

scholarly journals Urinary Stone Disease and Cardiovascular Disease Risk in a Rural Chinese Population

2017 ◽  
Vol 2 (6) ◽  
pp. 1042-1049 ◽  
Author(s):  
Xiaohong Fan ◽  
Sahir Kalim ◽  
Wenling Ye ◽  
Sophia Zhao ◽  
Jie Ma ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chinese Population ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stone Disease

scholarly journals Dual Impedance Cardiography: An Inexpensive and Reliable Method to Assess Arterial Stiffness

2020 ◽  
Author(s):  
Mark R. Scudder ◽  
J. Richard Jennings ◽  
Caitlin Marie DuPont ◽  
Kimberly Lockwood ◽  
Shrenik H. Gadagkar ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Arterial Stiffness ◽  
Large Scale ◽  
Impedance Cardiography ◽  
Reliable Method ◽  
Disease Risk ◽  
Community Sample ◽  
Cardiovascular Disease Risk ◽  
Strong Positive Correlation ◽  
Ensemble Averaging

Pulse wave velocity (PWV) is a common measure of arterial stiffness. Non-invasive methods to measure PWV are widely used in biomedical studies of aging and cardiovascular disease, but they are rarely used in psychophysiology. Barriers to wider use include the prohibitive costs of specialized equipment and need for trained technicians (e.g., ultrasonographers). Here, we describe an impedance cardiography method to measure PWV. By this method, impedance signals are dually collected from the thorax and calf. Combined with ensemble averaging of vascular signals, this dual impedance cardiography (d-ICG) method allows for the measurement of aortic flow onset and the arrival time of peripheral pulse waveforms to compute PWV. In a community sample of adults (aged 19–78 years), PWV measured with d-ICG exhibited a strong positive correlation with age. Moreover, age-specific mean PWV values were within the normative reference intervals established by large scale studies using other techniques. PWV derived from d-ICG exhibited high test-retest reliability across several days, as well as excellent inter-rater reliability. Lastly, PWV exhibited expected associations with known cardiovascular disease risk factors (i.e., blood pressure) and indicators of autonomic cardiovascular control. d-ICG is an inexpensive and reliable method to assess arterial stiffness.

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