The role of sperm and oocyte in fetal programming: Is Lamarck making a comeback?

Author(s):  
Renata Santos Tavares ◽  
João Ramalho‐Santos
Keyword(s):  
2012 ◽  
Vol 206 (1) ◽  
pp. S100-S101
Author(s):  
Giuseppe Chiossi ◽  
Maged Costantine ◽  
Michael Makhlouf ◽  
Talar Kechichian ◽  
Julio Mateus ◽  
...  

Author(s):  
Daniela Fanni ◽  
C. Gerosa ◽  
V. M. Nurchi ◽  
M. Manchia ◽  
L. Saba ◽  
...  

AbstractMagnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence. Magnesium status is relevant in fetal development during gestation and in the newborn growth during the perinatal period. Moreover, magnesium is able to influence fetal programming and disease presentation in childhood or adulthood. The aim of this review is to focus on this metal homeostasis, analyzing its normal values, the causes of hypomagnesemia, the interaction with drugs and other conditions, and the diseases associated with magnesium value alteration during pregnancy, in order to study its role in fetal programming of adult diseases. The data here reported clearly indicated the existence of a connection between magnesium status and human pathology starting from intrauterine life and extending into childhood and adulthood.


2013 ◽  
Vol 4 (6) ◽  
pp. 442-457 ◽  
Author(s):  
H. M. Salihu ◽  
A. Salinas-Miranda ◽  
C. de la Cruz ◽  
A. P. Alio

Preterm birth, low birthweight, intrauterine growth retardation and small for gestational age are birth phenotypes that significantly contribute to life-long morbidity and mortality. This review examines the epidemiologic and biologic evidence of folic acid (FA) as a potential population-based intervention to curtail some adverse birth phenotypic expressions, and by extension, their later physical and neurodevelopmental consequences. We outlined a feto-placental adaptation categorization taking into account how prenatal insults may be encoded in fetal development, the adaptive success of the feto-placental response, and subsequent expression in the health of the fetus. Although there are plausible biological pathways that can be implicated, we found that the epidemiological evidence on the role of perinatal FA nutriture and fetal programming of adverse birth phenotypes is still inconclusive. Because biologic and epidemiological considerations alone do not suffice in deciphering the utility of FA in averting adverse birth phenotypes, we proposed a biopsychosocial model that takes into account multi-layered psychosocial contexts for improving subsequent research studies in this area.


2016 ◽  
Vol 22 (3) ◽  
pp. 28
Author(s):  
O. A. Melkozerova ◽  
N. V. Bashmakova ◽  
E. V. Volkova ◽  
T. B. Tretyakova ◽  
G. N. Chistyakova

2005 ◽  
Vol 209 (S 2) ◽  
Author(s):  
L Schäffer ◽  
T Burkhardt ◽  
R Arlettaz ◽  
E Beinder
Keyword(s):  

2019 ◽  
Vol 36 (S 02) ◽  
pp. S33-S36 ◽  
Author(s):  
Vassilios Fanos ◽  
Clara Gerosa ◽  
Cristina Loddo ◽  
Gavino Faa

AbstractIn the present article, we discuss the following topics: (1) the fetal programming of adult kidney diseases and (2) the role of neonatologists in the regenerative renal medicine, based on the activation of resident renal SC. Here, we report the most important steps of our collaboration between neonatologists, nephrologists, and pathologists. Nephrologists should be more interested in clinical data regarding the first month of life in the womb of their adult patients, being particularly focused on birth weight and on the weeks of gestation at birth, without forgetting data regarding maternal status during gestation and neonatal asphyxia. Neonatologists should be aware that any preterm or low birthweight infant should be considered as a subject with fewer glomeruli, probably predicted to develop renal disease later in life.


2020 ◽  
Vol 47 (5) ◽  
pp. 907-915 ◽  
Author(s):  
Nirajan Shrestha ◽  
Simone L. Sleep ◽  
James S.M. Cuffe ◽  
Olivia J. Holland ◽  
Anthony V. Perkins ◽  
...  

The Placenta ◽  
2011 ◽  
pp. 1-9 ◽  
Author(s):  
Louiza Belkacemi ◽  
D. Michael Nelson ◽  
Mina Desai ◽  
Michael G. Ross

Sign in / Sign up

Export Citation Format

Share Document