scholarly journals C5a anaphylatoxin and its role in critical illness-induced organ dysfunction

2018 ◽  
Vol 48 (12) ◽  
pp. e13028 ◽  
Author(s):  
Alexander J. T. Wood ◽  
Arlette Vassallo ◽  
Charlotte Summers ◽  
Edwin R. Chilvers ◽  
Andrew Conway-Morris
Author(s):  
Greet Hermans

Chapter 12 introduces various issues surrounding organ dysfunction following critical illness and ICU hospitalizations. It covers possible complications that can arise from various organ system failures or problems during ICU stays, including difficult ventilator weaning and tracheostomy, local complications from endotracheal tubes (ETTs), surviving acute kidney injury (AKI), and decreased functional capacity and decreased QoL.


1996 ◽  
Vol 22 (9) ◽  
pp. 856-861 ◽  
Author(s):  
F. S. S. Leijten ◽  
A. W. De Weerd ◽  
D. C. J. Poortvliet ◽  
V. A. De Ridder ◽  
C. Ulrich ◽  
...  

2022 ◽  
Author(s):  
Raphael K Kayambankadzanja ◽  
Carl Otto Schell ◽  
Martin Gerdin Warnberg ◽  
Thomas Tamras ◽  
Hedi Mollazadegan ◽  
...  

Objective As critical illness and critical care lack consensus definitions, this study aims to explore how the concepts are used, describe their defining attributes and propose potential definitions. Design We used the Walker and Avant stepwise approach to concept analysis. The uses and definitions of the concepts were identified through a scoping review of the literature and an online survey of 114 global clinical experts. Through content analysis of the data we extracted codes, categories and themes to determine the concepts defining attributes and we proposed potential definitions. To assist understanding, we present model, related and contrary cases concerning the concepts, we identified antecedents and consequences to the concepts, and defined empirical referents. Results The defining attributes of critical illness were a high risk of imminent death; vital organ dysfunction; requirement for care to avoid death; and potential reversibility. The defining attributes of critical care were the identification, monitoring and treatment of critical illness; vital organ support; initial and sustained care; any care of critical illness; and specialized human and physical resources. Our proposed definition of critical illness is, a state of ill health with vital organ dysfunction, a high risk of imminent death if care is not provided and the potential for reversibility. Our proposed definition of critical care is, the identification, monitoring and treatment of patients with critical illness through the initial and sustained support of vital organ functions. Conclusion The concepts critical illness and critical care lack consensus definitions and have varied uses. Through concept analysis of uses and definitions in the literature and among experts we have identified the defining attributes of the concepts and propose definitions that could aid clinical practice, research, and policy making.


2021 ◽  
Vol 23 (1) ◽  
pp. 117-118
Author(s):  
Rachit Datta ◽  
◽  
Gian Luca Di Tanna ◽  
Amanda Harley ◽  
Luregn J Schlapbach ◽  
...  

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; it affects 55 000 Australians and results in around 8700 deaths annually.1 Studies have shown that junior doctors have reduced awareness of the importance of sepsis as a time-critical illness.2 Whether this deficiency is a consequence of insufficient training on sepsis in medical schools is unknown. This study evaluated the knowledge of sepsis among medical students in two Australian universities


Author(s):  
Robert D Stevens

Chapter 26 is an introduction to devoted to biological mechanisms underpinning organ dysfunction and repair in critical illness, and how research has generated fundamental insights into the biology of conditions, such as sepsis and ARDS, and has suggested important new therapeutic paradigms. It also specifically addresses issues surrounding genetic susceptibility, cognitive deficiency, frailty, myocardial ischaemia, muscle wasting, sepsis-associated encephalopathy (SAE), CIP, and structural muscle alterations.


2013 ◽  
Vol 28 (1) ◽  
pp. e21-e22
Author(s):  
Daniel Knox ◽  
Jason P. Jones ◽  
Kathryn G. Kuttler ◽  
Colin K. Grissom ◽  
Samuel M. Brown

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