Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients

2016 ◽  
Vol 46 (5) ◽  
pp. 418-424 ◽  
Author(s):  
Jasmina Ivanišević ◽  
Jelena Kotur-Stevuljević ◽  
Aleksandra Stefanović ◽  
Slavica Spasić ◽  
Violeta Vučinić Mihailović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Paraoxonase 1 ◽  
Amyloid A ◽  
And Oxidative Stress

scholarly journals Paired Measurements of Paraoxonase 1 and Serum Amyloid A as Useful Disease Markers

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Kazuhiko Kotani ◽  
Toshiyuki Yamada ◽  
Alejandro Gugliucci
Keyword(s):  
Oxidative Stress ◽  
Serum Amyloid A ◽  
Clinical Chemistry ◽  
Experimental Studies ◽  
Density Lipoprotein ◽  
Serum Amyloid ◽  
Paraoxonase 1 ◽  
Amyloid A ◽  
Disease Entities ◽  
And Oxidative Stress

Paraoxonase 1 (PON1) and serum amyloid A (SAA) are proteins carried by high-density lipoprotein (HDL) particles. Among the HDL-associated protein molecules, SAA, an inflammation-related marker, and PON1, an antioxidant marker, tend to change in relatively clear opposite directions in physiological situations. In clinical chemistry, paired measurements of both markers may provide useful information to understand dysfunctional HDL in diseases with inflammation and oxidative stress conditions. Actually, limited clinical studies have suggested that the combined use of PON1 and SAA may be a tool for observing the pathophysiology of some disease entities. From the findings of experimental studies, PON1 appears to be cooperatively regulated by inflammation- and oxidative stress-related molecules linked with SAA regulation in humans. More studies remain to be performed to ascertain the value of paired measurements of both promising markers in clinical practice.

Paired measurement of serum amyloid A (SAA) and paraoxonase 1 (PON1) as useful markers in breast cancer recurrence

2015 ◽  
Vol 48 (16-17) ◽  
pp. 1181-1183 ◽  
Author(s):  
Christine Bobin-Dubigeon ◽  
Armelle Lefrançois ◽  
Jean-Marc Classe ◽  
Marie-Pierre Joalland ◽  
Jean-Marie Bard
Keyword(s):  
Breast Cancer ◽  
Serum Amyloid A ◽  
Cancer Recurrence ◽  
Serum Amyloid ◽  
Breast Cancer Recurrence ◽  
Paraoxonase 1 ◽  
Amyloid A ◽  
Paired Measurement

Lower Serum Paraoxonase-1 Activity Is Related to Higher Serum Amyloid A Levels in Metabolic Syndrome

2011 ◽  
Vol 42 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Paul Jan Willem Herman Kappelle ◽  
Johan Bijzet ◽  
Bouke Pier Hazenberg ◽  
Robin Pieter Frank Dullaart
Keyword(s):  
Metabolic Syndrome ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Paraoxonase 1 ◽  
Lower Serum ◽  
Amyloid A ◽  
Serum Paraoxonase

scholarly journals Serum paraoxonase 1 activity in cats: analytical validation, reference intervals, and correlation with serum amyloid A and alpha-1-acid glycoprotein

2020 ◽  
Vol 32 (6) ◽  
pp. 844-855
Author(s):  
Gabriele Rossi ◽  
Sara Meazzi ◽  
Alessia Giordano ◽  
Saverio Paltrinieri
Keyword(s):  
Acute Phase ◽  
Room Temperature ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Paraoxonase 1 ◽  
Biological Behavior ◽  
Pon1 Activity ◽  
Analytical Validation ◽  
Acid Glycoprotein ◽  
Amyloid A

Paraoxonase 1 (PON1) is an inflammation marker associated with lipid oxidation and is used as a diagnostic marker in people. There is no information about the suitable substrate and analytic performance in cats, or its biological behavior compared with other inflammation markers. Our aims were to validate a paraoxon-based method to measure PON1 activity in feline serum, to assess stability of PON1 under different storage conditions and the impact of interfering elements, to determine a reference interval (RI) for healthy cats, and to correlate PON1 activity with 2 major acute-phase proteins. Intra- and inter-assay precision, accuracy, and RI were assessed using fresh serum. The same specimens were stored at room temperature, refrigerated, or frozen, and retested at defined intervals. Hemolysis, lipemia, and icterus were simulated to study interferences. PON1 results were compared to serum amyloid A (SAA) and alpha-1-acid glycoprotein (AGP) results. Analytical validation yielded precise and accurate results. PON1 activity is stable for up to 24 h at room temperature and up to 48 h at 4°C. Freezing at −20°C results in an increase after 72 h, with return to baseline values after 1 wk, that again increases after 6 mo. Only hyperlipemia interfered with PON1 activity. The RI based on 71 healthy cats was 58–154 U/L. PON1 activity was negatively correlated with AGP, but not with SAA. Serum PON1 activity can be measured accurately in cats, and it acts as a negative acute-phase protein.

scholarly journals Reciprocal and Coordinate Regulation of Serum Amyloid A Versus Apolipoprotein A-I and Paraoxonase-1 by Inflammation in Murine Hepatocytes

2006 ◽  
Vol 26 (8) ◽  
pp. 1806-1813 ◽  
Author(s):  
Chang Yeop Han ◽  
Tsuyoshi Chiba ◽  
Jean S. Campbell ◽  
Nelson Fausto ◽  
Michelle Chaisson ◽  
...  
Keyword(s):  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Paraoxonase 1 ◽  
Coordinate Regulation ◽  
Amyloid A ◽  
Apolipoprotein A
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