A long-term risk-benefit analysis of low-dose aspirin in primary prevention

2016 ◽  
Vol 46 (2) ◽  
pp. 130-140 ◽  
Author(s):  
I-Chen Wu ◽  
Hui-Min Hsieh ◽  
Fang-Jung Yu ◽  
Meng-Chieh Wu ◽  
Tzung-Shiun Wu ◽  
...  
Keyword(s):  
Primary Prevention ◽  
Low Dose ◽  
Benefit Analysis ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Risk Benefit Analysis

scholarly journals Effects of low-dose aspirin on the osseointegration process in rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ana Carolina Lupepsa ◽  
Paula Vargas-Sanchez ◽  
Marcella Goetz Moro ◽  
Leomar Emanuel Almeida Mecca ◽  
Marcela Claudino ◽  
...  
Keyword(s):  
Low Dose ◽  
Inhibitory Effect ◽  
Control Group ◽  
Implant Placement ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Male Wistar Rats ◽  
Bone To Implant Contact ◽  
Bone Deposition

Abstract Background Several drugs are capable of promoting changes in bone metabolism. The aim of this study was to evaluate the effect of long-term low-dose aspirin (LDA) therapy on implant osseointegration. Methods Male Wistar rats were divided into 4 groups (n = 8/group) according to oral gavage solution received prior (42 days) to the implant surgery on the tibia. The control group was treated with saline solution for 7 (CG-7) and 28 (CG-28) days. The use of low-dose aspirin was performed in AG groups (6.75 mg/kg of aspirin) for 7 (AG-7) and 28 (AG-28) days. After experimental periods, histomorphometric evaluation of bone-to-implant contact (BIC) and the bone area between threads (BABT) was performed. Results Reduced BIC values were detected in AG-7 (62.8% ± 17.1) group compared to AG-28 (91.9% ± 5.4), CG-7 (82.7% ± 15.2), and CG-28 (89.9% ± 9.7). BABT evaluation revealed lower values in AG-7 (70.9% ± 15.2) compared to AG-28 (95.4% ± 3.7) and CG-28 (87.1% ± 10.2) groups. Conclusions The treatment with low doses of aspirin promoted a discrete inhibitory effect in the early stages (7 days) of repair after implant placement, specifically in the bone deposition. However, these effects were not detected in the late stages (28 days), considering BIC and BABT parameters.

scholarly journals Effect of Low-Dose Aspirin on Primary Prevention of Cardiovascular Events in Japanese Diabetic Patients at High Risk

2013 ◽  
Vol 77 (12) ◽  
pp. 3023-3028 ◽  
Author(s):  
Sadanori Okada ◽  
Takeshi Morimoto ◽  
Hisao Ogawa ◽  
Mio Sakuma ◽  
Hirofumi Soejima ◽  
...  
Keyword(s):  
Primary Prevention ◽  
High Risk ◽  
Cardiovascular Events ◽  
Low Dose ◽  
Diabetic Patients ◽  
Dose Aspirin ◽  
Low Dose Aspirin
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