Soluble urokinase plasminogen activator receptor, C-reactive protein and triglyceride are associated with heart rate variability in non-diabetic Danes

2013 ◽  
Vol 43 (5) ◽  
pp. 457-468 ◽  
Author(s):  
Theodoros Intzilakis ◽  
Gro Hartmann ◽  
Mette R. Mouridsen ◽  
Jesper Eugen-Olsen ◽  
Preman Kumarathurai ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Plasminogen Activator ◽  
Urokinase Plasminogen Activator ◽  
C Reactive Protein ◽  
Urokinase Plasminogen Activator Receptor ◽  
Reactive Protein ◽  
Plasminogen Activator Receptor

scholarly journals Soluble urokinase plasminogen activator receptor for the prediction of ventilator-associated pneumonia

2019 ◽  
Vol 5 (1) ◽  
pp. 00212-2018 ◽  
Author(s):  
Pouline M. van Oort ◽  
Lieuwe D. Bos ◽  
Pedro Póvoa ◽  
Paula Ramirez ◽  
Antoni Torres ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Critically Ill ◽  
Pulmonary Infection ◽  
Urokinase Plasminogen Activator ◽  
Clinical Pulmonary Infection Score ◽  
Ventilator Associated Pneumonia ◽  
C Reactive Protein ◽  
Urokinase Plasminogen Activator Receptor ◽  
Reactive Protein ◽  
Plasminogen Activator Receptor

IntroductionDiagnosing ventilator-associated pneumonia (VAP) remains challenging. Soluble urokinase plasminogen activator receptor (suPAR) has prognostic value in critically ill patients with systemic infection. We hypothesised that plasma suPAR levels accurately predict development of VAP.MethodsThis observational, multicentre, prospective cohort study compared patients at risk for VAP with a control group. Plasma and tracheal aspirate samples were collected. Plasma suPAR levels were measured on the day of diagnosis and 3 days before diagnosis.ResultsThe study included 24 VAP patients and 19 control patients. The suPAR concentration measured 3 days before diagnosis was significantly increased in VAP patients versus matched samples of control patients (area under the receiver operating characteristic curve (AUC) 0.68, 95% CI 0.52–1.00; p=0.04). Similar results were found on the day of diagnosis (AUC 0.77, 95% CI 0.6–0.93; p=0.01). Plasma suPAR was significantly higher in deceased patients (AUC 0.79, 95% CI 0.57–1.00; p<0.001). Combining suPAR with the Clinical Pulmonary Infection Score, C-reactive protein and/or procalcitonin led to a significantly increased discriminative accuracy for predicting VAP and an increased specificity.ConclusionssuPAR can be used to diagnose VAP with a fair diagnostic accuracy and has a moderate prognostic accuracy to be used in critically ill intensive care unit patients. Its performance improves when added to other clinically available biomarkers (C-reactive protein and procalcitonin) or scoring systems (Clinical Pulmonary Infection Score and Sepsis-related Organ Failure Assessment).

The analysis of the soluble urokinase plasminogen activator receptor (suPAR) concentrations in the patients with dental restorations

2019 ◽  
Vol 54 (2) ◽  
pp. 73-80 ◽  
Author(s):  
Rafał Mastalerz ◽  
Marek Paradowski ◽  
Urszula Rychlik ◽  
Rafał Nikodem Wlazeł
Keyword(s):  
Inflammatory Response ◽  
Oral Cavity ◽  
Plasminogen Activator ◽  
White Blood Cells ◽  
Urokinase Plasminogen Activator ◽  
Urokinase Plasminogen Activator Receptor ◽  
Chronic Inflammatory Response ◽  
Reactive Protein ◽  
The People ◽  
Plasminogen Activator Receptor

The only method to restore missing teeth, refunded by the Polish National Health Found, is acrylic partial denture, which is often the cause of prosthetic stomatopathy, that affects both the dentition and the mucous membrane. The soluble urokinase plasminogen activator receptor (suPAR) was used to assess this type of chronic inflammatory response, which is also a factor that accelerates the development of atherosclerosis and its clinical outcomes. Comparative analysis of suPAR concentrations (ELISA suPARNostic, Virogates) was performed in group of people using acrylic dentures for up to 5 years in relation to the group of people using them longer and against the group of the people who do not use prostheses, also in relation to other laboratory parameters related to inflammatory response. The results of the study conducted in the total group of 117 people, of which 77 were using acrylic dentures, showed that in patients who used them longer (> 5years), greater intensity of changes in the oral cavity and higher suPAR levels (Me=3.95 ng/mL) were observed, in comparison to patients who do not use prostheses (Me=3.12 ng/mL), as well as patients who used them less than 5 years (Me=3.43 ng/mL); p = 0.00002. The concentration of suPAR significantly positively correlated with the concentration of LDL cholesterol, triglycerides, C-reactive protein and the number of white blood cells and neutrophils in the studied population (R>0.2; p<0.05), and was significantly higher in smokers (3.84 vs 3.24 ng/mL, p=0.04). No other laboratory marker of inflammatory response showed similar discriminatory properties. The demonstrated increases in suPAR concentrations were associated with existing local inflammation in patients using acrylic dentures. More intense inflammatory process occurred in patients using prostheses over 5 years and who have pathological changes in the oral cavity.

scholarly journals Soluble urokinase plasminogen activator receptor level in individuals of advanced age

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rafal N. Wlazel ◽  
Katarzyna Szwabe ◽  
Agnieszka Guligowska ◽  
Tomasz Kostka
Keyword(s):  
Plasminogen Activator ◽  
Urokinase Plasminogen Activator ◽  
Multiple Regression Model ◽  
Community Dwelling ◽  
Clinical Value ◽  
Urokinase Plasminogen Activator Receptor ◽  
Protein Levels ◽  
Reactive Protein ◽  
Supar Level ◽  
Plasminogen Activator Receptor

Abstract Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker whose clinical value has been tested in various groups of patients. The aim of the present study was to determine the suPAR level in a previously uninvestigated population of 182, generally healthy, community-dwelling seniors aged 74–89 years. In addition to suPAR level, selected laboratory parameters of heart and kidney function, lipid and C-reactive protein levels were determined. A group of 45 younger individuals aged 24–66 years was used for comparison. The seniors had higher suPAR levels than younger controls: 3.79 ng/mL (95% CI 3.64–3.96 ng/mL) vs. 3.16 ng/mL (95% CI 2.86–3.45 ng/mL). These levels increased further with advancing age, and were similar in women and men. A multiple regression model confirmed that biomarker level was related to cardiac function, renal function and inflammation, and this remained after adjusting for age. These correlation patterns were similar in older women and men.

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