scholarly journals Oxidized LDL Receptor 1 gene polymorphism in patients with Metabolic Syndrome

2012 ◽  
Vol 43 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Vincenzo O. Palmieri ◽  
Brigida Coppola ◽  
Ignazio Grattagliano ◽  
Valentina Casieri ◽  
Giovanna Cardinale ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphism ◽  
Oxidized Ldl ◽  
Ldl Receptor

scholarly journals Soluble Lectin-Like Oxidized LDL Receptor 1 as a Possible Mediator of Endothelial Dysfunction in Patients With Metabolic Syndrome

2014 ◽  
Vol 29 (3) ◽  
pp. 184-190 ◽  
Author(s):  
S. Civelek ◽  
M. Kutnu ◽  
H. Uzun ◽  
F. Erdenen ◽  
E. Altunoglu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Oxidized Ldl ◽  
Ldl Receptor

scholarly journals OLR1 gene polymorphism and oxidized LDL levels in metabolic syndrome in Indian population

2018 ◽  
Vol 22 (4) ◽  
pp. 530 ◽  
Author(s):  
Elvia Jamatia ◽  
Pramod Lali ◽  
BC Koner ◽  
DK Dhanwal ◽  
Mirza Masroor ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphism ◽  
Indian Population ◽  
Oxidized Ldl

Glycation and HMG-CoA Reductase Inhibitors: Implication in Diabetes and Associated Complications

2019 ◽  
Vol 15 (3) ◽  
pp. 213-223 ◽  
Author(s):  
Rabia Nabi ◽  
Sahir Sultan Alvi ◽  
Mohd. Saeed ◽  
Saheem Ahmad ◽  
Mohammad Salman Khan
Keyword(s):  
Oxidized Ldl ◽  
Advanced Glycation Endproducts ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Protective Role ◽  
Therapeutic Effects ◽  
Hmg Coa Reductase ◽  
Toxicological Effects ◽  
Coa Reductase

Introduction: Diabetes Mellitus (DM) acts as an absolute mediator of cardiovascular risk, prompting the prolonged occurrence, size and intricacy of atherosclerotic plaques via enhanced Advanced Glycation Endproducts (AGEs) formation. Moreover, hyperglycemia is associated with enhanced glyco-oxidized and oxidized Low-Density Lipoprotein (LDL) possessing greater atherogenicity and decreased the ability to regulate HMG-CoA reductase (HMG-R). Although aminoguanidine (AG) prevents the AGE-induced protein cross-linking due to its anti-glycation potential, it exerts several unusual pharmaco-toxicological effects thus restraining its desirable therapeutic effects. HMG-R inhibitors/statins exhibit a variety of beneficial impacts in addition to the cholesterol-lowering effects. Objective: Inhibition of AGEs interaction with receptor for AGEs (RAGE) and glyco-oxidized-LDL by HMG-R inhibitors could decrease LDL uptake by LDL-receptor (LDL-R), regulate cholesterol synthesis via HMG-R, decrease oxidative and inflammatory stress to improve the diabetes-associated complications. Conclusion: Current article appraises the pathological AGE-RAGE concerns in diabetes and its associated complications, mainly focusing on the phenomenon of both circulatory AGEs and those accumulating in tissues in diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy, discussing the potential protective role of HMG-R inhibitors against diabetic complications.

scholarly journals Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients

2016 ◽  
Vol 1 (2) ◽  
pp. aaf8943-aaf8943 ◽  
Author(s):  
Thomas Condamine ◽  
George A. Dominguez ◽  
Je-In Youn ◽  
Andrew V. Kossenkov ◽  
Sridevi Mony ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Oxidized Ldl ◽  
Ldl Receptor ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

F(ab′)2 fragments of anti-oxidized LDL IgG attenuate vascular inflammation and atherogenesis in diabetic LDL receptor-deficient mice

2016 ◽  
Vol 173 ◽  
pp. 50-56 ◽  
Author(s):  
Yanchun Li ◽  
Zhongyang Lu ◽  
Yan Huang ◽  
Maria F. Lopes-Virella ◽  
Gabriel Virella
Keyword(s):  
Oxidized Ldl ◽  
Vascular Inflammation ◽  
Ldl Receptor ◽  
Deficient Mice
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