Left ventricular systolic dyssynchrony index and endothelial dysfunction parameters as subclinical predictors of cardiovascular involvement in patients with beta‐thalassemia major

2021 ◽  
Author(s):  
Hatice Solmaz ◽  
Ali Kemal Cabuk ◽  
Zeynep Altin ◽  
Esin Albudak Ozcan ◽  
Oner Ozdogan
Keyword(s):  
Endothelial Dysfunction ◽  
Thalassemia Major ◽  
Left Ventricular ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Cardiovascular Involvement ◽  
Dyssynchrony Index

Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major

2005 ◽  
Vol 105 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Constadina Aggeli ◽  
Charalambos Antoniades ◽  
Constadina Cosma ◽  
Christine Chrysohoou ◽  
Dimitris Tousoulis ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Inflammatory Process ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major

Left Ventricular Rotational Dynamics in Beta Thalassemia Major: A Speckle-Tracking Echocardiographic Study

2012 ◽  
Vol 25 (10) ◽  
pp. 1083-1090 ◽  
Author(s):  
Ines Monte ◽  
Sergio Buccheri ◽  
Vera Bottari ◽  
Anita Blundo ◽  
Salvatore Licciardi ◽  
...  
Keyword(s):  
Speckle Tracking ◽  
Thalassemia Major ◽  
Left Ventricular ◽  
Rotational Dynamics ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Echocardiographic Study

Electrocardiographic parameters among beta-thalassemia major patients

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Patsourakos ◽  
C Aggeli ◽  
K Gatzoulis ◽  
S Delicou ◽  
Y Dimitroglou ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Significant Proportion ◽  
Thalassemia Major ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Beta Thalassemia ◽  
Qtc Interval ◽  
Interval Duration ◽  
Ventricular Ejection Fraction ◽  
Beta Thalassemia Major

Abstract Background/Introduction The majority of beta thalassemia major (β-TM) patients suffer from cardiac disorders, while a significant proportion of them die suddenly. Twelve-lead and signal-averaged electrocardiography are simple, inexpensive, readily available tools for identifying an unfavorable arrhythmiological substrate by detecting the presence of arrhythmias, conduction abnormalities and late potentials (LPs) in these patients. Methods 47 β-TM patients and 30 healthy controls were submitted to twelve-lead and signal-averaged electrocardiography. Basal rhythm, heart rate, PR interval duration, QRS complex duration and morphology, QTc interval duration and prevalence of LPs were recorded. Results β-TM patients demonstrated a more prolonged PR segment (167.74 msec vs. 147.07 msec) (p=0.043), a higher prevalence of PR prolongation (21.05% vs. 0%) (p=0.013) and a higher prevalence of LPs (18/47, 38.3% vs. 2/30, 6.7%) (p=0.002) compared with controls. In particular, every single SAECG parameter significantly differed among patients compared with controls. Among patients, left ventricular ejection fraction was marginally lower and QTc more prolonged among LPs positive subgroup compared with LPs negative subgroup. The prevalence of atrial fibrillation among b-TM patients was estimated at 10.64%. Conclusions β-TM patients have a higher prevalence of a prolonged PR segment, atrial fibrillation and LPs. Twelve-lead and SAECG performance was feasible in all subjects and constitutes a readily available tool for assessing myocardial electrophysiological alterations in this patient group, that could have significant impact on survival and quality of life with timely application of appropriate treatment. Funding Acknowledgement Type of funding source: None

scholarly journals Left ventricular diastolic Doppler characteristics in beta-thalassemia major.

Circulation ◽  
1993 ◽  
Vol 88 (3) ◽  
pp. 1127-1135 ◽  
Author(s):  
D T Kremastinos ◽  
D P Tsiapras ◽  
G A Tsetsos ◽  
E I Rentoukas ◽  
H P Vretou ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Left Ventricular ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major

Left ventricular functions in patients with beta-thalassemia major: a speckle tracking imaging study

2020 ◽  
Vol 33 (1) ◽  
pp. 138
Author(s):  
AmirI Lashin ◽  
AhmedA Khattab ◽  
MohamedF Elnoamany ◽  
NaglaaF Ahmed ◽  
DoaaM Elian
Keyword(s):  
Speckle Tracking ◽  
Imaging Study ◽  
Thalassemia Major ◽  
Left Ventricular ◽  
Beta Thalassemia ◽  
Speckle Tracking Imaging ◽  
Beta Thalassemia Major ◽  
Ventricular Functions

scholarly journals Left atrial deformation parameters among beta-thalassemia major patients

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
D Patsourakos ◽  
C Aggeli ◽  
K Gatzoulis ◽  
S Delicou ◽  
Y Dimitroglou ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Iron Overload ◽  
Left Atrial ◽  
Thalassemia Major ◽  
Left Ventricular ◽  
Beta Thalassemia ◽  
Left Atrial Strain ◽  
Beta Thalassemia Major ◽  
Deformation Parameters ◽  
Atrial Strain

Abstract Introduction Atrial cardiomyopathy is present in a significant proportion of beta thalassemia major (β-TM) patients, complicating their clinical condition. The diagnosis of atrial cardiomyopathy is challenging using conventional echocardiographic techniques. Purpose In our study we aimed to identify the presence of atrial cardiomyopathy by applying novel echocardiographic techniques in these patients. Methods 56 β-TM patients (mean age 39.3±9 years, 50% male sex) and 30, age and sex matched, healthy controls were examined by transthoracic echocardiography. Conventional echocardiographic parameters were estimated alongside with deformation indices (left atrial strain at reservoir (LASr), conduit (LAScd) and contraction (LASct) phase respectively as well as left ventricular global longitudinal strain (GLS)). T2* was calculated by cardiac magnetic resonance imaging in β-TM patients. Results LAVI, E/e' ratio, GLS and left atrial deformation parameters differed between patients and controls. In patient group, left atrial deformation indices were correlated with LAVI, E/e' ratio, GLS and T2* (Table 1). GLS was also correlated with LAVI, but not with T2* or E/e' ratio. T2* was correlated only with left atrial deformation indices. Patient with prior episodes of atrial fibrillation were older, had increased E/e' and LAVI and impaired left atrial deformation indices but did not differ in terms of GLS or T2* (Figure 1). Patients with iron overload differed only in terms of left atrial deformation parameters. Conclusions Atrial deformation indices could be of clinical use in the early detection of atrial cardiomyopathy. Impaired left atrial strain may be associated with silent atrial fibrillation and be indicative of myocardial iron overload. FUNDunding Acknowledgement Type of funding sources: None. Correlation table Scatter plot of T2* and LASr

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