Authors' Response: The three faces of Takotsubo cardiomyopathy in a single patient

2020 ◽  
Vol 37 (7) ◽  
pp. 1136-1137
Author(s):  
Scott E. Janus ◽  
Eugene Chang ◽  
Brian D. Hoit
2019 ◽  
Vol 37 (1) ◽  
pp. 135-138 ◽  
Author(s):  
Scott E. Janus ◽  
Brian D. Hoit

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Teng J. Peng ◽  
Nicholas D. Patchett ◽  
Sheilah A. Bernard

We report two serious and unusual complications of benzodiazepine withdrawal in a single patient: takotsubo cardiomyopathy and catatonia. This 61-year-old female patient was brought to the emergency department with lethargy and within hours had declined into a state of catatonia. Although there was never a complaint of chest pain, ECG showed deep anterior T-wave inversions and cardiac enzymes were elevated. An echocardiogram was consistent with takotsubo cardiomyopathy. She later received 1 mg of midazolam and within minutes had resolution of catatonic symptoms. Careful history revealed that she had omitted her daily dose of lorazepam for 3 days prior to admission. To our knowledge, the case presented herein is the first report of simultaneous catatonia and takotsubo cardiomyopathy in the setting of benzodiazepine withdrawal. The pathogenesis of both conditions is poorly understood but may be indirectly related to the sudden decrease inγ-aminobutyric acid (GABA) signaling during benzodiazepine withdrawal.


1967 ◽  
Vol 10 (2) ◽  
pp. 367-372 ◽  
Author(s):  
James D. Miller ◽  
Arthur F. Niemoeller

Results of intelligibility tests on a single patient with a severe discrimination loss for speech are reported. The patient was tested with four different hearing aids and with no aid, and the effects of opportunity for lipreading, background noise, and reverberation were evaluated. The tests appear to allow an accurate estimate of the amount of help to be expected in various situations and show that an aid with good fidelity is clearly superior to the others tested. The destructive effects of background noise and reverberation are demonstrated separately and in combination.


2005 ◽  
Vol 38 (15) ◽  
pp. 81
Author(s):  
DEBORAH LEVENSON
Keyword(s):  

2018 ◽  
Vol 37 (11) ◽  
pp. 803-807
Author(s):  
B. J. Connemann ◽  
T. Dahme ◽  
T. Tesfay ◽  
M. Gahr ◽  
M. Elsayed

Zusammenfassung Gegenstand und Ziel: Das Tako-Tsubo-Syndrom (TTS) ähnelt klinisch einem akuten Myokardinfarkt und ist häufig mit emotionalem oder physischem Stress assoziiert. Patienten mit TTS stellen sich daher häufig zuerst in einer psychiatrischen Klinik vor; dies kann die adäquate Diagnostik und Therapie verzögern, insbesondere wenn der Psychiater nicht mit TTS vertraut ist. Material und Methoden: Ein klinischer Fall eines TTS wird vorgestellt und diskutiert und das Krankheitsbild des TTS vorgestellt. Ergebnisse: Eine 43-jährige Patientin stellte sich notfallmäßig in unserer psychiatrischen Ambulanz vor. Unmittelbar vor der Vorstellung war es am Arbeitsplatz zu erheblicher Schikane der Patientin gekommen (Mobbing). Zum Vorstellungszeitpunkt beklagte die Patientin akute linksthorakale Schmerzen sowie seit einigen Wochen bestehend gedrückte Stimmung, verminderten Antrieb, Anhedonie, generalisierte Ängste und Schlafprobleme. Das Elektrokardiogramm (EKG) war unauffällig, das Serumtroponin jedoch deutlich erhöht. Die Patientin wurde daraufhin in die Abteilung für Kardiologie verlegt. Herzkatheter und Kardio-MRT zeigten eine apikale Ballonbildung (apical ballooning) und linksventrikuläre Dysfunktion, passend zu TTS. Schlussfolgerungen und klinische Relevanz: Bei Patienten mit akuter Psychopathologie und kardialen und/oder thorakalen Symptomen sollten ein EKG und eine Bestimmung des Serumtroponins durchgeführt werden.


2019 ◽  
Author(s):  
M Hassan ◽  
S Schmid ◽  
B Siepe ◽  
B Haager ◽  
B Passlick

2011 ◽  
Vol 9 (2) ◽  
pp. 119 ◽  
Author(s):  
Karen Mrejen-Shakin ◽  
Ricardo Lopez ◽  
Mohandas M Shenoy ◽  
◽  
◽  
...  

Objective:To report a case of seizure-induced takotsubo cardiomyopathy with rare etiology and rarer complications.Methods:A 50-year-old woman had multiple epileptic seizures and later developed acute heart failure complicated by ventricular fibrillation and shock. A two-dimensional echocardiogram revealed apical ballooning of the left ventricle resembling a takotsubo (a Japanese fisherman's pot used to trap octopi). The apex was also hypokinetic.Results:The hemodynamic abnormalities normalized with defibrillation, assisted ventilation, inotropic support, and pressor agents. More importantly, the apical ballooning deformity and systolic dysfunction reversed. The echocardiogram normalized three months later. A nuclear treadmill stress test was negative for ischemia.Conclusions:Apical ballooning of the left ventricle and hypokinesis are typical echocardiographic features in takotsubo cardiomyopathy, a stress-induced heart disease. It may follow severe emotional, physical, and neurologic stressors, in our rare case, grand mal seizures (0.2 % of all takotsubo disease patients). Also rare are life-threatening complications. Based on these observations, in a case with severe stress followed by acute heart failure, takotsubo cardiomyopathy should be a major diagnostic consideration. The dramatic initial triggering event, in our case an epileptic seizure, should not mask the possibility of coexisting takotsubo cardiomyopathy. Awareness of this disease, anticipation of complications, and two-dimensional echocardiography will help channel the management in the right direction.


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