Prognostic significance of left ventricular end diastolic pressure using E/E' in patients with hypertrophic cardiomyopathy

2019 ◽  
Vol 36 (12) ◽  
pp. 2167-2175
Author(s):  
Hala Mahfouz Badran ◽  
Ghada Soltan ◽  
Reda Almeleigi ◽  
Naglaa Faheem ◽  
Magdi H. Yacoub
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Diastolic Pressure ◽  
Prognostic Significance ◽  
Left Ventricular

Left Ventricular End-Diastolic Pressure-Volume Relationships in Hypertrophic Cardiomyopathy

CHEST Journal ◽  
1983 ◽  
Vol 84 (1) ◽  
pp. 54-57 ◽  
Author(s):  
Michael Tendera ◽  
Lech Polonski ◽  
Ewa Kozielska
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Diastolic Pressure ◽  
Left Ventricular

scholarly journals Prognostic significance of cardiac magnetic resonance-based markers in patients with hypertrophic cardiomyopathy

2021 ◽  
Author(s):  
Zsofia Dohy ◽  
Liliana Szabo ◽  
Attila Toth ◽  
Csilla Czimbalmos ◽  
Rebeka Horvath ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Myocardial Fibrosis ◽  
Ventricular Arrhythmias ◽  
Prognostic Significance ◽  
Strain Analysis ◽  
Left Ventricular ◽  
Icd Therapy ◽  
Lv Mass

AbstractThe prognosis of patients with hypertrophic cardiomyopathy (HCM) varies greatly. Cardiac magnetic resonance (CMR) is the gold standard method for assessing left ventricular (LV) mass and volumes. Myocardial fibrosis can be noninvasively detected using CMR. Moreover, feature-tracking (FT) strain analysis provides information about LV deformation. We aimed to investigate the prognostic significance of standard CMR parameters, myocardial fibrosis, and LV strain parameters in HCM patients. We investigated 187 HCM patients who underwent CMR with late gadolinium enhancement and were followed up. LV mass (LVM) was evaluated with the exclusion and inclusion of the trabeculae and papillary muscles (TPM). Global LV strain parameters and mechanical dispersion (MD) were calculated. Myocardial fibrosis was quantified. The combined endpoint of our study was all-cause mortality, heart transplantation, malignant ventricular arrhythmias and appropriate implantable cardioverter defibrillator (ICD) therapy. The arrhythmia endpoint was malignant ventricular arrhythmias and appropriate ICD therapy. The LVM index (LVMi) was an independent CMR predictor of the combined endpoint independent of the quantification method (p < 0.01). The univariate predictors of the combined endpoint were LVMi, global longitudinal (GLS) and radial strain and longitudinal MD (MDL). The univariate predictors of arrhythmia events included LVMi and myocardial fibrosis. More pronounced LV hypertrophy was associated with impaired GLS and increased MDL. More extensive myocardial fibrosis correlated with impaired GLS (p < 0.001). LVMi was an independent CMR predictor of major events, and myocardial fibrosis predicted arrhythmia events in HCM patients. FT strain analysis provided additional information for risk stratification in HCM patients.

scholarly journals Tachycardia-induced myocardial ischemia and diastolic dysfunction potentiate secretion of ANP, not BNP, in hypertrophic cardiomyopathy

2006 ◽  
Vol 290 (3) ◽  
pp. H1064-H1070 ◽  
Author(s):  
Shinsuke Kido ◽  
Naoyuki Hasebe ◽  
Yoshinao Ishii ◽  
Kenjiro Kikuchi
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Myocardial Ischemia ◽  
Diastolic Dysfunction ◽  
Diastolic Pressure ◽  
Systolic Function ◽  
Left Ventricular ◽  
Atrial Pacing ◽  
Catheter Tip ◽  
Lv Systolic Function ◽  
Lv Diastolic Dysfunction

The aim of this study was to investigate what factor determines tachycardia-induced secretion of atrial and brain natriuretic peptides (ANP and BNP, respectively) in patients with hypertrophic cardiomyopathy (HCM). HCM patients with normal left ventricular (LV) systolic function and intact coronary artery ( n = 22) underwent rapid atrial pacing test. The cardiac secretion of ANP and BNP and the lactate extraction ratio (LER) were evaluated by using blood samples from the coronary sinus and aorta. LV end-diastolic pressure (LVEDP) and the time constant of LV relaxation of tau were measured by a catheter-tip transducer. These parameters were compared with normal controls ( n = 8). HCM patients were divided into obstructive (HOCM) and nonobstructive (HNCM) groups. The cardiac secretion of ANP was significantly increased by rapid pacing in HOCM from 384 ± 101 to 1,268 ± 334 pg/ml ( P < 0.05); however, it was not significant in control and HNCM groups. In contrast, the cardiac secretion of BNP was fairly constant and rather significantly decreased in HCM ( P < 0.01). The cardiac ANP secretion was significantly correlated with changes in LER ( r = −0.57, P < 0.01) and tau ( r = 0.73, P < 0.001) in HCM patients. Tachycardia potentiates the cardiac secretion of ANP, not BNP, in patients with HCM, particularly when it induces myocardial ischemia and LV diastolic dysfunction.

scholarly journals 587 Exercise induced pulmonary hypertension in hypertrophic cardiomyopathy: a combined cardiopulmonary exercise test-echocardiographic study

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Federica Re ◽  
Geza Halasz ◽  
Francesco Moroni ◽  
Matteo Beltrami ◽  
Pasquale Baratta ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Hypertrophic Cardiomyopathy ◽  
Exercise Test ◽  
Functional Limitation ◽  
Prognostic Significance ◽  
Cardiopulmonary Exercise Test ◽  
Left Ventricular ◽  
Peak Exercise ◽  
Cardiopulmonary Exercise ◽  
Exercise Induced

Abstract Aims Pulmonary arterial hypertension (PAH) has been described in patients with hypertrophic cardiomyopathy (HCM) and it was associated with a worse prognosis. Nevertheless in most HCM patients, despite normal pulmonary pressures at rest, congestive symptoms are elicited by exercise. In the present study, combining cardiopulmonary exercise test (CPET) with echocardiography, we aimed to evaluate the presence of exercise-induced pulmonary hypertension (EiPAH) its role in functional limitation and its prognostic significance in a cohort of patients with obstructive and non-obstructive HCM. Methods and results 182 HCM patients (35% females, mean age 47.5 ± 15.9) undergoing CPET. During CPET, LVOT velocities and trans-tricuspid gradient were measured. Thirty-seven patients (20%) developed sPAP &gt; 40 mmHg at peak exercise (EiPAH). EiPAH was associated with an lower exercise performance, larger left atrial volumes, higher left ventricular gradient and higher VE/VCO2 slope .At multivariable model baseline sPAP (P &lt; 0.0001) and baseline left ventricular obstruction (LVOT) (P = 0.028) were significantly associated with EiPAH .Kaplan-Meier curve analysis showed EiPAH was a significant predictor of HCM –related morbidity (hazards ratio: 6.21, 95% CI: 1.47–26.19; P = 0.05; 4.21, 95% CI: 1.94–9.12; P &lt; 0.001) for the primary and the secondary endpoint respectively. Conclusions EiPAH was present in about one fifth of HCM patients without evidence of elevated pulmonary pressures at rest, and was associated with adverse clinical outcome. Diagnosing EiPAH by exercise echo/CPET may help physicians to detect early stage of PAH requiring a closer clinical monitoring and individualized treatment strategies.

scholarly journals Coronary Arteriographic Profile in Hypertrophic Cardiomyopathy (HCM)

2004 ◽  
Vol 3 (3) ◽  
pp. 24
Author(s):  
Iqbal Hasan ◽  
KMHSS Haque ◽  
Shaffiuddin Ahmed ◽  
MA Siddique ◽  
SK Banerjee ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Hypertrophic Cardiomyopathy ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Military Hospital ◽  
Cross Sectional ◽  
Ventricular Systolic Pressure ◽  
Coronary Patients

This cross-sectional study was carried out in department of cardiology, Combined Military Hospital, Dhaka, Bangladesh and department of cardiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period of April 2000 to November 2001. The study was designed to see the coronary arteriographic (CAG) pattern in patients with Hypertrophic Cardiomyopathy and to compare the CAG findings between HCM patients and normal coronary patients, HCM was diagnosed by using diagnostic criteria defined by Western Working Group. The patients with hypertention, congenitalheart disease, valvular heart disease, coronary artery disease were excluded from the study. Among total 60 subjects, 30 had HCM and 30 age and sex matched control. The mean age of cases was 45.00±15.38 years and control subjects was 44.35±15.14 years. HCM cases had significantly higher left ventricular systolic pressure, higher left ventricular end diastolic pressure and more ejection fraction than control. Origin of coronary artery both in control and HCM cases were normal.

scholarly journals Biphasic changes in left ventricular end-diastolic pressure during dynamic exercise in patients with nonobstructive hypertrophic cardiomyopathy

2001 ◽  
Vol 38 (2) ◽  
pp. 335-343 ◽  
Author(s):  
Yasushi Takeichi ◽  
Mitsuhiro Yokota ◽  
Mitsunori Iwase ◽  
Hideo Izawa ◽  
Takao Nishizawa ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Diastolic Pressure ◽  
Left Ventricular ◽  
Dynamic Exercise
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