Interatrial septal fat thickness and left atrial stiffness are mechanistic links between nonalcoholic fatty liver disease and incident atrial fibrillation

2018 ◽  
Vol 36 (2) ◽  
pp. 249-256 ◽  
Author(s):  
Ragab A. Mahfouz ◽  
Mohammad Gouda ◽  
Islam Galal ◽  
Mohamed S. Ghareb
Keyword(s):  
Atrial Fibrillation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Left Atrial ◽  
Nonalcoholic Fatty Liver ◽  
Fat Thickness ◽  
Left Atrial Stiffness

scholarly journals Nonalcoholic fatty liver disease and the risk of atrial fibrillation stratified by body mass index: a nationwide population-based study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
So-Ryoung Lee ◽  
Kyung-Do Han ◽  
Eue-Keun Choi ◽  
Seil Oh ◽  
Gregory Y. H. Lip
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Increased Risk ◽  
The Impact

AbstractWe evaluated the association between nonalcoholic fatty liver disease (NAFLD) and incident atrial fibrillation (AF) and analyzed the impact of NAFLD on AF risk in relation to body mass index (BMI). A total of 8,048,055 subjects without significant liver disease who were available fatty liver index (FLI) values were included. Subjects were categorized into 3 groups based on FLI: < 30, 30 to < 60, and ≥ 60. During a median 8-year of follow-up, 534,442 subjects were newly diagnosed as AF (8.27 per 1000 person-years). Higher FLI was associated with an increased risk of AF (hazard ratio [HR] 1.053, 95% confidence interval [CI] 1.046–1.060 in 30 ≤ FLI < 60, and HR 1.115, 95% CI 1.106–1.125 in FLI ≥ 60). In underweight subjects (BMI < 18.5 kg/m2), higher FLI raised the risk of AF (by 1.6-fold in 30 ≤ FLI < 60 and by twofold in FLI ≥ 60). In normal- and overweight subjects, higher FLI was associated with an increased risk of AF, but the HRs were attenuated. In obese subjects, higher FLI was not associated with higher risk of AF. NAFLD as assessed by FLI was independently associated with an increased risk of AF in nonobese subjects with BMI < 25 kg/m2. The impact of NAFLD on AF risk was accentuated in lean subjects with underweight.

scholarly journals Impact of Nonalcoholic Fatty Liver Disease on Arrhythmia Recurrence Following Atrial Fibrillation Ablation

2020 ◽  
Vol 6 (10) ◽  
pp. 1278-1287
Author(s):  
Eoin Donnellan ◽  
Thomas G. Cotter ◽  
Oussama M. Wazni ◽  
Mohamed B. Elshazly ◽  
Arshneel Kochar ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Atrial Fibrillation Ablation ◽  
Nonalcoholic Fatty Liver

Nonalcoholic fatty liver disease is associated with increased risk of atrial fibrillation

2020 ◽  
Vol 40 (7) ◽  
pp. 1594-1600 ◽  
Author(s):  
Xiaoyan Cai ◽  
Sulin Zheng ◽  
Ying Liu ◽  
Yan Zhang ◽  
Jianhua Lu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Increased Risk

scholarly journals Nonalcoholic Fatty Liver Disease Is Associated with Increased Atrial Fibrillation Risk in an Elderly Chinese Population: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yu Zhang ◽  
Peifei Li ◽  
Min Miao ◽  
Yi Liu ◽  
Yue Pan ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Chinese Population ◽  
Elderly Adults ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver ◽  
Elderly Chinese

Background. Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors. There are rare researches performed among elderly adults.Aims. We conducted this cross-sectional analysis of elderly adults (≥65 years) to investigate the association between atrial fibrillation and nonalcoholic fatty liver disease.Methods. We analyzed clinical data of the elderly adults (≥ 65 years) who had health examination in Zhenhai Lianhua Hospital, Ningbo, China, in 2014.Results. 522 of the 1688 participants were diagnosed with nonalcoholic fatty liver disease, and 39 participants were diagnosed as having atrial fibrillation. Nonalcoholic fatty liver disease was associated with risk factors for AF in the elderly Chinese population (OR 1.95, 95% CI 1.03-3.69). Adjustments for age, gender, systolic blood pressure, fasting plasma glucose,γ-glutamyl transpeptidase, high-density lipoprotein, triglycerides, total cholesterol and albumin, nonalcoholic fatty liver disease, and prevalent atrial fibrillation remained statistically significant (OR 2.76, 95% CI 1.32-5.77).Conclusions. Our results show that nonalcoholic fatty liver disease is associated with an increased risk of atrial fibrillation in an elderly Chinese population.

scholarly journals Epicardial fat thickness and nonalcoholic fatty liver disease in obese subjects

Obesity ◽  
2013 ◽  
Vol 22 (2) ◽  
pp. 332-336 ◽  
Author(s):  
Gianluca Iacobellis ◽  
Giorgio Barbarini ◽  
Claudio Letizia ◽  
Giuseppe Barbaro
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Epicardial Fat ◽  
Nonalcoholic Fatty Liver ◽  
Epicardial Fat Thickness ◽  
Obese Subjects ◽  
Fat Thickness

scholarly journals Nonalcoholic Fatty Liver Disease and the Risk of Atrial Fibrillation

2020 ◽  
Vol 8 (B) ◽  
pp. 530-535
Author(s):  
Mahmoud A. Abou Omar ◽  
Ahmed Alaarag ◽  
Sherief Abd-Elsalam ◽  
Mohamed El-Abgeegy ◽  
Rehab Ahmed ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver ◽  
Onset Atrial Fibrillation ◽  
New Onset

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is now the factor behind the development of liver cirrhosis, liver cell failure, and liver transplantation in many cases. However, its relation to atrial fibrillation (AF) could not be cleared up. AIM: The purpose of the study was to evaluate prevalence of AF in the setting of NAFLD; the association between them, and to evaluate risk factors of AF in this category of patients. METHODS: This cross-sectional study was performed on 400 patients between January 2018 and June 2019. These patients were analyzed for the presence of NAFLD and presence of persistent or chronic AF. RESULTS: There were 138 patients with NAFLD, and 20 patients with persistent or permanent AF. Factors associated with AF were old age, male gender, and high values of aspartate aminotransferase, alanine-aminotransferase, γ-glutamyltranspeptidase, and serum uric acid. The participants with AF had a significantly greater prevalence of NAFLD than those without AF. CONCLUSION: Incidence and prevalence of atrial fibrillation in NAFLD patients were high. Severity of liver disease was an important predictor of new-onset atrial fibrillation.

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