Echocardiography Detects Elevated Left Ventricular Filling Pressures in Heart Transplant Recipients

2014 ◽  
Vol 32 (3) ◽  
pp. 411-419 ◽  
Author(s):  
Odd Bech-Hanssen ◽  
Waleed Al-Habeeb ◽  
Waqas Ahmed ◽  
Giovanni Di Salvo ◽  
Valeria Pergola ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Left Ventricular ◽  
Left Ventricular Filling ◽  
Transplant Recipients ◽  
Heart Transplant Recipients ◽  
Ventricular Filling

scholarly journals Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients

2008 ◽  
Vol 29 (22) ◽  
pp. 2742-2750 ◽  
Author(s):  
S. S. Kushwaha ◽  
E. Raichlin ◽  
Y. Sheinin ◽  
W. K. Kremers ◽  
K. Chandrasekaran ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Heart Transplant ◽  
Left Ventricular ◽  
Transplant Recipients ◽  
Ventricular Mass ◽  
Heart Transplant Recipients

Enhanced brain natriuretic peptide response to peak exercise in heart transplant recipients

1998 ◽  
Vol 85 (6) ◽  
pp. 2270-2276 ◽  
Author(s):  
Bernard Geny ◽  
Anne Charloux ◽  
Eliane Lampert ◽  
Jean Lonsdorfer ◽  
Pascal Haberey ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Transplantation ◽  
Left Ventricular Mass ◽  
Heart Transplant ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Peak Exercise ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

We investigated the atrial (ANP) and brain natriuretic peptides (BNP), catecholamines, heart rate, and blood pressure responses to graded upright maximal cycling exercise of eight matched healthy subjects and cardiac-denervated heart transplant recipients (HTR). Baseline heart rate and diastolic blood pressure, together with ANP (15.2 ± 3.7 vs. 4.4 ± 0.8 pmol/l; P < 0.01) and BNP (14.3 ± 2.6 vs. 7.4 ± 0.6 pmol/l; P< 0.01), were elevated in HTR, but catecholamine levels were similar in both groups. Peak exercise O2uptake and heart rate were lower in HTR. Exercise-induced maximal ANP increase was similar in both groups (167 ± 34 vs. 216 ± 47%). Enhanced BNP increase was significant only in HTR (37 ± 8 vs. 16 ± 8%; P < 0.05). Similar norepinephrine but lower peak epinephrine levels were observed in HTR. ANP and heart rate changes from rest to 75% peak exercise were negatively correlated ( r = −0.76, P < 0.05), and BNP increase was correlated with left ventricular mass index ( r = 0.83, P < 0.01) after heart transplantation. Although ANP increase was not exaggerated, these data support the idea that the chronotropic limitation secondary to sinus node denervation might stimulate ANP release during early exercise in HTR. Furthermore, the BNP response to maximal exercise, which is related to the left ventricular mass index of HTR, is enhanced after heart transplantation.

Sign in / Sign up

Export Citation Format

Share Document