Huge Mitral Annular Caseoma: Complementary Role of Multimodality Imaging

2013 ◽  
Vol 30 (5) ◽  
pp. E138-E140 ◽  
Author(s):  
Metin Cagdas ◽  
Hasan Sahan ◽  
Yalcin Velibey ◽  
Nazmi Calik ◽  
Sinan Sahin
Keyword(s):  
Multimodality Imaging ◽  
Complementary Role

scholarly journals Complementary Role of Multimodality Imaging in the Evaluation of Intracardiac Lymphoma in an HIV-Infected Man

Circulation ◽  
2007 ◽  
Vol 115 (12) ◽  
Author(s):  
Kian Keong Poh ◽  
Ricardo C. Cury ◽  
Jorge Solis ◽  
Alan J. Fischman ◽  
Malissa J. Wood
Keyword(s):  
Multimodality Imaging ◽  
Complementary Role

scholarly journals Cardiomyopathy of uncertain etiology: Complementary role of multimodality imaging with cardiac MRI and 18FDG PET

2009 ◽  
Vol 17 (2) ◽  
pp. 328-332 ◽  
Author(s):  
Orla Buckley ◽  
Leona Doyle ◽  
Robert Padera ◽  
Neal Lakdawala ◽  
Sharmila Dorbala ◽  
...  
Keyword(s):  
Cardiac Mri ◽  
Multimodality Imaging ◽  
18Fdg Pet ◽  
Complementary Role ◽  
Uncertain Etiology

Congenital coronary anomalies: a complementary role of multimodality imaging

2011 ◽  
Vol 12 (7) ◽  
pp. 522-523 ◽  
Author(s):  
Nicola DʼAmato ◽  
Michele Correale ◽  
Gianluca Camarda ◽  
Carlo M Altamura ◽  
Osvaldo Pierfelice ◽  
...  
Keyword(s):  
Multimodality Imaging ◽  
Coronary Anomalies ◽  
Complementary Role ◽  
Congenital Coronary Anomalies

scholarly journals Through thick and thin: Diagnosis of transthyretin cardiac amyloidosis through non-invasive multimodality imaging

2021 ◽  
pp. 201010582110061
Author(s):  
Raja Ezman Raja Shariff ◽  
Hafisyatul Aiza Zainal Abidin ◽  
Sazzli Kasim
Keyword(s):  
Cardiac Amyloidosis ◽  
Troponin T ◽  
Multimodality Imaging ◽  
High Sensitivity ◽  
Dark Blood ◽  
Non Invasive ◽  
Doppler Study ◽  
Alternative Means ◽  
High Sensitivity Troponin T

Cardiac amyloidosis is a severely underdiagnosed cause of heart failure with preserved ejection fraction. We report a case of highly probable transthyretin (ATTR) cardiac amyloidosis (ATTR-CA) diagnosed through the assistance of non-invasive multimodality imaging. An 81-year-old man presented with worsening dyspnoea, reduced effort tolerance and limb swelling. Examination and bedside investigations demonstrated congestive cardiac failure. On arrival, N-terminal-pro B-type natriuretic peptide was 2400 ng/L, and high-sensitivity troponin T was 78 mmol/L. Echocardiography showed severe left and right ventricular hypertrophy, and a Doppler study revealed diastolic dysfunction. Cardiac magnetic resonance imaging revealed on non-conventional dark blood sequence an abnormal inversion time for nulling myocardium suggestive of infiltrative disease, including amyloidosis. The patient was referred for nuclear-based studies involving technetium-99m pyrophosphate which demonstrated changes highly diagnostic of ATTR-CA. Early diagnosis of ATTR-CA remains paramount due to the increasing availability of disease-modifying therapies. Current guidelines recognise the role of multimodality imaging in confidently recognising the disease without the need for histological evidence in the appropriate context, providing an alternative means of diagnosis.

scholarly journals PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling

2021 ◽  
Vol 22 (10) ◽  
pp. 5112
Author(s):  
Lotte van Beek ◽  
Éilís McClay ◽  
Saleha Patel ◽  
Marianne Schimpl ◽  
Laura Spagnolo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Parp Inhibitors ◽  
Covalent Modification ◽  
Activation Mechanism ◽  
Cancer Therapies ◽  
Damage Repair ◽  
Complementary Role ◽  
Functional Understanding

Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes, catalysing the covalent modification of proteins, DNA, and themselves. They attach mono- or poly-ADP-ribose to targets using NAD+ as a substrate. Poly-ADP-ribosylation (PARylation) is central to the important functions of PARP enzymes in the DNA damage response and nucleosome remodelling. Activation of PARP happens through DNA binding via zinc fingers and/or the WGR domain. Modulation of their activity using PARP inhibitors occupying the NAD+ binding site has proven successful in cancer therapies. For decades, studies set out to elucidate their full-length molecular structure and activation mechanism. In the last five years, significant advances have progressed the structural and functional understanding of PARP1-3, such as understanding allosteric activation via inter-domain contacts, how PARP senses damaged DNA in the crowded nucleus, and the complementary role of histone PARylation factor 1 in modulating the active site of PARP. Here, we review these advances together with the versatility of PARP domains involved in DNA binding, the targets and shape of PARylation and the role of PARPs in nucleosome remodelling.

scholarly journals Changing paradigm for treatment of heavily calcified coronary artery disease. A complementary role of rotational atherectomy and intravascular lithotripsy with shockwave balloon: a case report

2020 ◽  
Author(s):  
Shana Tehrani ◽  
Sudhir Rathore ◽  
Vinod Achan
Keyword(s):  
Coronary Artery ◽  
Interventional Cardiology ◽  
Rotational Atherectomy ◽  
Stent Restenosis ◽  
Case Summary ◽  
Stent Expansion ◽  
Complementary Role ◽  
Artery Disease ◽  
Stenotic Lesions

Abstract Background Management of heavily calcified coronary arteries is still a major challenge in interventional cardiology. Inadequate stent expansion in calcific lesions is the single most important predictor of stent thrombosis and in-stent restenosis. Rotational atherectomy (RA) is an important tool to modify the calcium burden but is associated with limitations and requires specific skills. Intravascular lithotripsy (IVL) is a novel technique to treat calcified stenotic lesions and has been proposed as an alternative to RA with promising results. Case summary We report a case of a patient with severely calcified right coronary artery stenosis successfully treated with combination of RA and IVL. Discussion In this case, we demonstrate that the RA and IVL are complementary strategies, not sufficient on their own and not alternative to each other.

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