scholarly journals A population‐based linked cohort of cancer and primary care data: A new source to study the management of cancer in primary care

2021 ◽  
Author(s):  
Josephina G. Kuiper ◽  
Myrthe P. P. Herk‐Sukel ◽  
Valery E. P. P. Lemmens ◽  
Ernst J. Kuipers ◽  
Ron M. C. Herings
Keyword(s):  
Primary Care ◽  
Population Based ◽  
Primary Care Data

scholarly journals HIV infection and COVID-19 death: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

2020 ◽  
Author(s):  
Krishnan Bhaskaran ◽  
Christopher T Rentsch ◽  
Brian MacKenna ◽  
Anna Schultz ◽  
Amir Mehrkar ◽  
...  
Keyword(s):  
Primary Care ◽  
Hiv Infection ◽  
Cox Regression ◽  
Cohort Analysis ◽  
Geographical Area ◽  
Population Based ◽  
People Living With Hiv ◽  
Primary Care Data ◽  
Living With Hiv ◽  
Age And Sex

Background: It is unclear whether HIV infection is associated with risk of COVID-19 death. We aimed to investigate this in a large-scale population-based study in England. Methods: Working on behalf of NHS England, we used the OpenSAFELY platform to analyse routinely collected electronic primary care data linked to national death registrations. People with a primary care record for HIV infection were compared to people without HIV. COVID-19 death was defined by ICD-10 codes U07.1 or U07.2 anywhere on the death certificate. Cox regression models were used to estimate the association between HIV infection and COVID-19 death, initially adjusted for age and sex, then adding adjustment for index of multiple deprivation and ethnicity, and finally for a broad range of comorbidities. Interaction terms were added to assess effect modification by age, sex, ethnicity, comorbidities and calendar time. Results: 17.3 million adults were included, of whom 27,480 (0.16%) had HIV recorded. People living with HIV were more likely to be male, of black ethnicity, and from a more deprived geographical area than the general population. There were 14,882 COVID-19 deaths during the study period, with 25 among people with HIV. People living with HIV had nearly three-fold higher risk of COVID-19 death than those without HIV after adjusting for age and sex (HR=2.90, 95% CI 1.96-4.30). The association was attenuated but risk remained substantially raised, after adjustment for deprivation and ethnicity (adjusted HR=2.52, 1.70-3.73) and further adjustment for comorbidities (HR=2.30, 1.55-3.41). There was some evidence that the association was larger among people of black ethnicity (HR = 3.80, 2.15-6.74, compared to 1.64, 0.92-2.90 in non-black individuals, p-interaction=0.045) Interpretation: HIV infection was associated with a markedly raised risk of COVID-19 death in a country with high levels of antiretroviral therapy coverage and viral suppression; the association was larger in people of black ethnicity.

Sign in / Sign up

Export Citation Format

Share Document