The role of healthcare professionals in HPV communication with head and neck cancer patients: A narrative synthesis of qualitative studies

2020 ◽  
Vol 29 (4) ◽  
Author(s):  
Mairead O’Connor ◽  
Bernadine O’Donovan ◽  
Jo Waller ◽  
Alan Ó. Céilleachair ◽  
Pamela Gallagher ◽  
...  
2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Shree Ram Lamichhane ◽  
Thanuja Thachil ◽  
Harriet Gee ◽  
Natalie Milic

Background. Circulating microRNAs (miRNAs) are potential molecular biomarkers for cancer detection; however, little is known about their prognostic role in head and neck cancer. This current study is aimed at evaluating the role of novel miRNAs in the survival of head and neck cancer patients. Materials and Methods. We performed a systematic literature search using online databases for articles published between December 2006 and February 2019. A meta-analysis was conducted to assess the correlation between miRNA expressions and overall survival (OS) among the selected head and neck cancer studies. After multilevel screening by reviewers, meta-analysis was performed using hazard ratios (HR) and associated 95% confidence interval (CI) of survival to calculate a pooled effect size. Result. A total of 1577 patients across 13 studies were included in the literature review, with 18 miRNAs upregulated and 4 miRNAs downregulated predicting a poor overall survival. The forest plot generated using cumulated survival data resulted in a pooled HR value of 2.943 (95% CI: 2.394-3.618) indicating a strong association of dysregulated miRNA expression with a poor outcome. Only 2 miRNAs—low levels of miR-9 and high levels of miR-483-5p—were observed in two studies, both showing a significant association with overall cancer survival. Conclusion. To our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the prognostic role of circulating miRNAs from blood in head and neck cancer patients. The combined effect estimates a HR across multiple studies and also supports the previous individual findings that an alteration in miRNA expression is highly associated with poor prognosis. This has the potential to use serum and/or plasma miRNAs as biomarkers and become novel tools for predicting the prognosis of head and neck cancer patients in the near future.


2019 ◽  
Vol 45 (1) ◽  
pp. 83-98 ◽  
Author(s):  
John Rocke ◽  
Oliver Mclaren ◽  
John Hardman ◽  
George Garas ◽  
Matthew E Smith ◽  
...  

Head & Neck ◽  
2003 ◽  
Vol 25 (11) ◽  
pp. 889-894 ◽  
Author(s):  
Beno�t Mesurolle ◽  
Fran�ois Mignon ◽  
Philippe Meingan ◽  
Christian Domenge ◽  
Manuella Vasile ◽  
...  

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e17017-e17017
Author(s):  
Ruchika Gutt ◽  
Steven H. Krasnow ◽  
Hosai Hesham ◽  
Andrea Burmeister ◽  
JoAnn Manning

2021 ◽  
Vol 11 ◽  
Author(s):  
Maria Karampela ◽  
Talya Porat ◽  
Vasiliki Mylonopoulou ◽  
Minna Isomursu

BackgroundThe incidents of Head and Neck Cancer (HNC) are rising worldwide, suggesting that this type of cancer is becoming more common. The foreseen growth of incidents signifies that future rehabilitation services will have to meet the needs of a wider population.ObjectiveThe aim of this paper is to explore the needs of patients, caregivers and healthcare professionals during HNC rehabilitation.MethodsThis paper reports the empirical findings from a case study that was conducted in a cancer rehabilitation center in Copenhagen to elicit the needs of HNC cancer patients, informal caregivers and healthcare professionals.ResultsFour areas of needs during the rehabilitation process were identified: service delivery, emotional, social and physical needs. Service delivery needs and emotional needs have been identified as the most prevalent.ConclusionsStakeholders’ needs during the rehabilitation process were found to be interrelated. All stakeholders faced service delivery challenges in the form of provision and distribution of information, including responsibilities allocation between municipalities, hospitals and rehabilitation services. Emotional and social needs have been reported by HNC patients and informal caregivers, underlining the importance of inclusion of all actors in the design of future healthcare interventions. Connected Health (CH) solutions could be valuable in provision and distribution of information.


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