scholarly journals The symptom phenotype of oncology outpatients remains relatively stable from prior to through 1 week following chemotherapy

2016 ◽  
Vol 26 (3) ◽  
pp. e12437 ◽  
Author(s):  
C. Miaskowski ◽  
B.A. Cooper ◽  
B. Aouizerat ◽  
M. Melisko ◽  
L.-M. Chen ◽  
...  
Keyword(s):  
Symptom Phenotype

Measurement equivalence of the autism symptom phenotype in children and youth

2013 ◽  
Vol 54 (12) ◽  
pp. 1346-1355 ◽  
Author(s):  
Eric Duku ◽  
Peter Szatmari ◽  
Tracy Vaillancourt ◽  
Stelios Georgiades ◽  
Ann Thompson ◽  
...  
Keyword(s):  
Measurement Equivalence ◽  
Children And Youth ◽  
Symptom Phenotype

scholarly journals Heterologous Movement Protein Strongly Modifies the Infection Phenotype of Cucumber Mosaic Virus

2002 ◽  
Vol 76 (7) ◽  
pp. 3554-3557 ◽  
Author(s):  
Emese Huppert ◽  
Dénes Szilassy ◽  
Katalin Salánki ◽  
Zoltán Divéki ◽  
Ervin Balázs
Keyword(s):  
Nicotiana Tabacum ◽  
Virus Infection ◽  
Cucumber Mosaic Virus ◽  
Mosaic Virus ◽  
Host Plants ◽  
Movement Protein ◽  
Long Distance ◽  
Cucumber Mosaic Cucumovirus ◽  
Nicotiana Debneyi ◽  
Symptom Phenotype

ABSTRACT A hybrid virus (CMVcymMP) constructed by replacing the movement protein (MP) of cucumber mosaic cucumovirus (CMV) with that of cymbidium ringspot tombusvirus (CymRSV) was viable and could efficiently spread both cell to cell and long distance in host plants. The hybrid virus was able to move cell to cell in the absence of functional CP, whereas CP-deficient CMV was restricted to single inoculated cells. In several Chenopodium and Nicotiana species, the symptom phenotype of the hybrid virus infection was clearly determined by the foreign MP gene. In Nicotiana debneyi and Nicotiana tabacum cv. Xanthi, the hybrid virus could move systemically, contrary to CymRSV.

scholarly journals Chino del tomate virus:Relationships to Other Begomoviruses and Identification of A-Component Variants that Affect Symptom Expression

2000 ◽  
Vol 90 (5) ◽  
pp. 546-552 ◽  
Author(s):  
J. K. Brown ◽  
Kristin M. Ostrow ◽  
Ali M. Idris ◽  
Drake C. Stenger
Keyword(s):  
Amino Acid ◽  
Genotypic Variation ◽  
Symptom Expression ◽  
Wild Type ◽  
Disease Symptoms ◽  
Phenotypic Differences ◽  
Interveinal Chlorosis ◽  
Leaf Curling ◽  
Symptom Phenotype ◽  
Severe Leaf

Phylogenetic and distance analyses place Chino del tomate virus (CdTV) in the New World clade of begomoviruses and indicate that CdTV and Tomato leaf crumple virus (TLCrV) are closely related strains of the same virus. One cloned CdTV A component (pCdTV-H6), when inoculated to tomato with the B component (pCdTV-B52), produced mild symptoms and low DNA titers. Another cloned CdTV A component (pCdTV-H8), when coinoculated to tomato with the B component, produced moderate leaf curling and veinal chlorosis similar to that of TLCrV. Coinoculation of both CdTV A components and the B component to tomato produced wild-type chino del tomate (CdT) disease symptoms consisting of severe leaf curling, veinal and interveinal chlorosis, and stunting. The two CdTV A components were nearly identical, except at nucleotide positions 1,722 and 2,324. The polymorphism at nucleotide 1,722 resulted in a change at Rep amino acid 261. The second polymorphism at nucleotide 2,324 resulted in changes at Rep amino acid 60 and AC4 amino acid 10. Two chimeric A components constructed by reciprocal exchange of a fragment bearing the polymorphic site at nucleotide 1,722 were evaluated for symptom phenotype. One chimeric A component (pCdTV-H86) produced wild-type CdT symptoms when coinoculated to tomato with the B component. The reciprocal chimeric A component (pCdTV-H68), when coin-oculated to tomato with the B component, also produced severe leaf curling, veinal chlorosis, and stunting. However, pCdTV-H68 induced less obvious interveinal chlorosis than wild-type or pCdTV-H86. Examination of A component genotypes recovered from tomato coinoculated with pCdTV-H6 and pCdTV-H8 indicated that recombination occurred to produce a genotype identical to pCdTV-H86. These results indicate that subtle genotypic variation has significant effects on symptom expression and may explain phenotypic differences observed among isolates and cloned DNAs of CdTV and TLCrV.

scholarly journals A severe symptom phenotype in tomato in Mali is caused by a reassortant between a novel recombinant begomovirus (Tomato yellow leaf curl Mali virus) and a betasatellite

2009 ◽  
Vol 10 (3) ◽  
pp. 415-430 ◽  
Author(s):  
LI-FANG CHEN ◽  
MARIA ROJAS ◽  
TATSUYA KON ◽  
KADIATOU GAMBY ◽  
BEATRIZ XOCONOSTLE-CAZARES ◽  
...  
Keyword(s):  
Severe Symptom ◽  
Tomato Yellow Leaf ◽  
Yellow Leaf ◽  
Symptom Phenotype ◽  
Leaf Curl

scholarly journals Irritable bowel syndrome-diarrhea: characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit

2014 ◽  
Vol 306 (1) ◽  
pp. G13-G26 ◽  
Author(s):  
Michael Camilleri ◽  
Eric W. Klee ◽  
Andrea Shin ◽  
Paula Carlson ◽  
Ying Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Principal Components Analysis ◽  
Principal Components ◽  
Quantitative Traits ◽  
Colonic Transit ◽  
Fecal Bile Acids ◽  
Components Analysis ◽  
Irritable Bowel ◽  
Symptom Phenotype

The study objectives were: to mine the complete exome to identify putative rare single nucleotide variants (SNVs) associated with irritable bowel syndrome (IBS)-diarrhea (IBS-D) phenotype, to assess genes that regulate bile acids in IBS-D, and to explore univariate associations of SNVs with symptom phenotype and quantitative traits in an independent IBS cohort. Using principal components analysis, we identified two groups of IBS-D ( n = 16) with increased fecal bile acids: rapid colonic transit or high bile acids synthesis. DNA was sequenced in depth, analyzing SNVs in bile acid genes ( ASBT, FXR, OSTα/β, FGF19, FGFR4, KLB, SHP, CYP7A1, LRH-1, and FABP6). Exome findings were compared with those of 50 similar ethnicity controls. We assessed univariate associations of each SNV with quantitative traits and a principal components analysis and associations between SNVs in KLB and FGFR4 and symptom phenotype in 405 IBS, 228 controls and colonic transit in 70 IBS-D, 71 IBS-constipation. Mining the complete exome did not reveal significant associations with IBS-D over controls. There were 54 SNVs in 10 of 11 bile acid-regulating genes, with no SNVs in FGF19; 15 nonsynonymous SNVs were identified in similar proportions of IBS-D and controls. Variations in KLB (rs1015450, downstream) and FGFR4 [rs434434 (intronic), rs1966265, and rs351855 (nonsynonymous)] were associated with colonic transit (rs1966265; P = 0.043), fecal bile acids (rs1015450; P = 0.064), and principal components analysis groups (all 3 FGFR4 SNVs; P < 0.05). In the 633-person cohort, FGFR4 rs434434 was associated with symptom phenotype ( P = 0.027) and rs1966265 with 24-h colonic transit ( P = 0.066). Thus exome sequencing identified additional variants in KLB and FGFR4 associated with bile acids or colonic transit in IBS-D.

scholarly journals Epidemiological and immunological features of obesity and SARS-CoV-2

2020 ◽  
Author(s):  
Eric J Nilles ◽  
Sameed M Siddiqui ◽  
Stephanie Fischinger ◽  
Yannic C Bartsch ◽  
Michael de Saint Aubin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Immune Response ◽  
Cohort Study ◽  
T Cell ◽  
Body Mass ◽  
Age Groups ◽  
Older Age ◽  
Viral Antigens ◽  
Symptom Phenotype

AbstractObesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response are poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and, remarkably homogenous immune activity across BMI categories suggests natural- and vaccine-induced protection may be similar across these groups.

Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation

2008 ◽  
Vol 294 (1) ◽  
pp. G13-G19 ◽  
Author(s):  
Michael Camilleri ◽  
Paula Carlson ◽  
Sanna McKinzie ◽  
April Grudell ◽  
Irene Busciglio ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Gastric Emptying ◽  
Gastrointestinal Motility ◽  
Colonic Motility ◽  
Acid Amide ◽  
Functional Gastrointestinal Disorders ◽  
Colonic Transit ◽  
Genotype Distribution ◽  
Rectal Sensation ◽  
Symptom Phenotype

Cannabinoid agonist inhibits gastrointestinal motility. The endocannabinoid, anandamide, is inactivated by fatty acid amide hydrolase (FAAH). A single nucleotide polymorphism in the human FAAH gene (C385A) reduces FAAH expression. Our aim was to evaluate associations between FAAH genotype variation and symptom phenotype, gastric emptying and volume, colonic transit, and rectal sensation in patients with functional gastrointestinal disorders (FGID). 482 FGID patients [Rome II positive, 159 constipation disorders, 184 diarrhea disorders (D-IBS), 86 mixed bowel function (M-IBS), 20 chronic abdominal pain (CAP), 33 functional dyspepsia], and 252 healthy volunteers (HV) underwent questionnaires and studies of phenotype and genotype from 2000 to 2007: 250 gastric emptying, 210 fasting and postprandial gastric volume, 152 colonic transit, and 123 rectal sensation. All had FAAH genotype [CC vs. polymorphic (CA/AA)] determined by TaqMan. FAAH genotype distribution of FGID patients and HV did not deviate from Hardy-Weinberg equilibrium. There was a significant association of FAAH genotype with FGID phenotype (overall χ2, P = 0.011) and with specific individual phenotypes ( P = 0.048). Thus FAAH CA/AA increases the odds (relative to HV) for D-IBS ( P = 0.008), M-IBS ( P = 0.012), and, possibly, CAP ( P = 0.055). There was a significant association of FAAH CA/AA genotype with accelerated colonic transit in D-IBS ( P = 0.037). There was no association of FAAH genotype with rectal sensation thresholds or ratings. The association of genetic variation in metabolism of endocannabinoids with symptom phenotype in D-IBS and M-IBS and with faster colonic transit in D-IBS supports the hypothesis that cannabinoid mechanisms may play a role in the control of colonic motility in humans and deserve further study.

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