Association between surgical excision margins and outcomes in patients with dermatofibrosarcoma protuberans: A meta‐analysis

2021 ◽  
Author(s):  
Yiyin Chen ◽  
Guan Jiang
Keyword(s):  
Meta Analysis ◽  
Dermatofibrosarcoma Protuberans ◽  
Surgical Excision ◽  
Excision Margins

Peripheral Excision Margins for Dermatofibrosarcoma Protuberans: A Meta-analysis of Spatial Data

2007 ◽  
Vol 14 (7) ◽  
pp. 2113-2120 ◽  
Author(s):  
Zebadiah Kimmel ◽  
Desiree Ratner ◽  
John Y. S. Kim ◽  
Jeffrey D. Wayne ◽  
Alfred W. Rademaker ◽  
...  
Keyword(s):  
Spatial Data ◽  
Meta Analysis ◽  
Dermatofibrosarcoma Protuberans ◽  
Excision Margins

scholarly journals Pitfall management of dermatofibrosarcoma protuberans on right leg

2019 ◽  
Vol 7 (9) ◽  
pp. 3586
Author(s):  
Gede Kesuma Winarta ◽  
Ida Bagus Made Suryawisesa
Keyword(s):  
Soft Tissue ◽  
Recurrence Rate ◽  
Skin Graft ◽  
Dermatofibrosarcoma Protuberans ◽  
Surgical Excision ◽  
Postoperative Evaluation ◽  
Sural Flap ◽  
Tissue Handling ◽  
Graft Area ◽  
Excision Margins

Dermatofibrosarcoma protuberans (DFSP) is a rare, locally invasive soft tissue sarcoma. The local recurrence rate is high, in some studies upwards of 60%, likely reflecting a failure to remove occult extensions of tumor. Surgical excision has been the treatment of choice for the resection of DFSP. Any pitfall on management therapy of DFSP not only increase the recurrence rate but also add new problems to patients with DFSP. 58-year-old male patient, came with a local recurrent of DFSP on his right leg. Then performed excision with margin one centimetre, and closing defect using pedicle sural flap, durante surgery turned pedicle on the flap is too short and because of poor soft tissue handling pedicle was injured. It consulted into the vascular division for evaluated and treatment pedicle. Postoperative evaluation, the flap experiences bluish due to vascularization compromised. It was decided to expose the flap and the defect was covered with skin graft. 2 months postoperative evaluation found local recurrent on skin graft area. Excision margins between 2 to 5 cm can reduce the recurrence rate. Proper planning in designing flaps to cover defects and the ability of good soft tissue handling is required to avoid new problems on management DFSP.

scholarly journals Adjuvant HPV Vaccination to Prevent Recurrent Cervical Dysplasia after Surgical Treatment: A Meta-Analysis

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 410
Author(s):  
Violante Di Donato ◽  
Giuseppe Caruso ◽  
Marco Petrillo ◽  
Evangelos Kontopantelis ◽  
Innocenza Palaia ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Meta Analysis ◽  
Hpv Vaccination ◽  
Cervical Dysplasia ◽  
Reduction Rate ◽  
Intraepithelial Neoplasia ◽  
Surgical Excision ◽  
Inclusion Criteria ◽  
Mean Differences ◽  
The Impact

Objective: The aim of this meta-analysis was to discuss evidence supporting the efficacy of adjuvant human papillomavirus (HPV) vaccination in reducing the risk of recurrent cervical intraepithelial neoplasia (CIN) 2 or greater after surgical treatment. Methods: A systematic literature search was performed for studies reporting the impact of HPV vaccination on reducing the risk of recurrence of CIN 2+ after surgical excision. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI). Results: Eleven studies met the inclusion criteria and were selected for analysis. In total, 21,310 patients were included: 4039 (19%) received peri-operational adjuvant HPV vaccination while 17,271 (81%) received surgery alone. The recurrence of CIN 2+ after treatment was significantly lower in the vaccinated compared with the unvaccinated group (OR 0.35; 95% CI 0.21–0.56; p < 0.0001). The recurrence of CIN 1+ after treatment was significantly lower in the vaccinated compared with the unvaccinated group (OR 0.51; 95% CI 0.31–0.83; p = 0.006). A non-significant trend of reduction rate of HPV persistence was observed in the vaccinated compared with the unvaccinated cohorts (OR was 0.84; 95% CI 0.61–1.15; p = 0.28). Conclusions: HPV vaccination, in adjuvant setting, is associated with a reduced risk of recurrent CIN 1+ and CIN 2+ after surgical treatment.

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