Successful treatment of pityriasis rubra pilaris with guselkumab: Serum CCL20 as a potential marker for the disease activity

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Hiroshi Nagai ◽  
Haruki Jimbo ◽  
Shoko Matsuura ◽  
Saori Tatsuoka ◽  
Erina Shiraki ◽  
...  
Keyword(s):  
Disease Activity ◽  
Successful Treatment ◽  
Pityriasis Rubra Pilaris ◽  
Potential Marker

scholarly journals AB0073 INTESTINAL PERMEABILITY IN SPONDYLOARTHRITIS: A SYSTEMATIC REVIEW OF THE LITERATURE

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1067.1-1067
Author(s):  
S. Hecquet ◽  
P. Totoson ◽  
H. Martin ◽  
C. Prati ◽  
D. Wendling ◽  
...  
Keyword(s):  
Systematic Review ◽  
Disease Activity ◽  
Intestinal Permeability ◽  
Intestinal Inflammation ◽  
Intestinal Barrier ◽  
Basic Research ◽  
Final Analysis ◽  
Potential Marker ◽  
Inflammatory Drugs ◽  
Permeability Evaluation

Background:Growing evidence argue for a role of the gut in the pathophysiology of various chronic rheumatic diseases such as spondyloarthritis (SpA). This so-called “gut-joint axis” involves dysbiosis, bacterial translocation, intestinal inflammation and increase in intestinal permeability. Recent data from clinical and basic research suggested that the integrity of the intestinal barrier might be a key determinant in translating autoimmunity to inflammation, making intestinal permeability a potential marker or a target for future therapies.Objectives:To analyse the available data on intestinal permeability in SpA patients and the effects of drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) on intestinal permeability.Methods:A systematic review was conducted. Without date restriction, the following databases were searched through September 1, 2020: Medline, Embase and Cochrane. Studies with patients with SpA assessing the intestinal permeability were selected. Some of the included studies have assessed the effect of NSAIDs on intestinal permeability.Results:A total of 12 studies were included in the final analysis. The 12 studies involved a total of 268 SpA patients, including 240 ankylosing spondylitis (AS). Among the studies included, four studies used the lactulose/mannitol test, four studies used the 51Cr-ethylenediaminetetraacetic test and two studies used the polyethylene glycols test. Nine of the 12 studies reported increased intestinal permeability regardless on the method used for intestinal permeability evaluation. Four studies evaluated the link between disease activity, assessed by CRP and ESR levels, and intestinal permeability and showed no correlation between increased intestinal permeability and markers of disease activity in AS patients. As regards the effects of NSAIDs on intestinal permeability, data are controversial. Two studies, including one evaluating indomethacin, did not show any influence of NSAIDs in AS patients, one study showed an increase in intestinal permeability under NSAIDs in only 60% of the patients, another study reported increased intestinal permeability. When comparing the effect of NSAIDs in patients with AS to healthy subjects, one study reported a comparable NSAIDs-induced increase in intestinal permeability in both groups.Conclusion:The results of our review suggest that increased intestinal permeability is present in SpA patients even in the absence of NSAIDs use and regardless of the method used to assess intestinal permeability. The effects of NSAIDs on intestinal permeability in SpA patients is more controversial and further studies are needed to clarify them.Disclosure of Interests:None declared

scholarly journals Successful treatment of pityriasis rubra pilaris with adalimumab - case report

2014 ◽  
Vol 20 (4) ◽  
Author(s):  
Erick A Bravo ◽  
Leonidas Carrion ◽  
Silvia M Paucar ◽  
Rossana Mendoza ◽  
Carlos Rivera
Keyword(s):  
Case Report ◽  
Successful Treatment ◽  
Pityriasis Rubra Pilaris

Successful Treatment of Refractory Type 1 Pityriasis Rubra Pilaris With Apremilast

2018 ◽  
Vol 22 (1) ◽  
pp. 104-105 ◽  
Author(s):  
Elvira Molina-Figuera ◽  
Álvaro González-Cantero ◽  
Elena Martínez-Lorenzo ◽  
Ana-Isabel Sánchez-Moya ◽  
Obdulia García-Olmedo ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Pityriasis Rubra Pilaris

Successful treatment of Pityriasis rubra pilaris with brodalumab

2019 ◽  
Vol 61 (2) ◽  
Author(s):  
Alina De Rosa ◽  
Alessio Gambardella ◽  
Gaetano Licata ◽  
Roberto Alfano ◽  
Giuseppe Argenziano
Keyword(s):  
Successful Treatment ◽  
Pityriasis Rubra Pilaris

Type III juvenile pityriasis rubra pilaris: a successful treatment with infliximab

2007 ◽  
Vol 0 (0) ◽  
pp. 070619172136007-??? ◽  
Author(s):  
M Ruzzetti ◽  
R Saraceno ◽  
I Carboni ◽  
M Papoutsaki ◽  
S Chimenti
Keyword(s):  
Successful Treatment ◽  
Type Iii ◽  
Pityriasis Rubra Pilaris

scholarly journals Successful Treatment of Refractory Pityriasis Rubra Pilaris With Secukinumab

2016 ◽  
Vol 152 (11) ◽  
pp. 1278 ◽  
Author(s):  
Daniel Schuster ◽  
Andrea Pfister-Wartha ◽  
Leena Bruckner-Tuderman ◽  
Christoph M. Schempp
Keyword(s):  
Successful Treatment ◽  
Pityriasis Rubra Pilaris
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